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Volumn 118, Issue 2, 2011, Pages 446-455

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR;

EID: 79960533396     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-07-294785     Document Type: Article
Times cited : (59)

References (54)
  • 1
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • DOI 10.1038/nri2000, PII NRI2000
    • Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol. 2007;7(5):340-352. (Pubitemid 46674485)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.5 , pp. 340-352
    • Shlomchik, W.D.1
  • 2
    • 0036550199 scopus 로고    scopus 로고
    • Cytolytic pathways in haematopoietic stem-cell transplantation
    • van den Brink MR, Burakoff SJ. Cytolytic pathways in haematopoietic stem-cell transplantation. Nat Rev Immunol. 2002;2(4):273-281. (Pubitemid 37323227)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.4 , pp. 273-281
    • Van Den, B.M.R.M.1    Burakoff, S.J.2
  • 3
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill GR, Ferrara JL. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95(9):2754-2759. (Pubitemid 30235880)
    • (2000) Blood , vol.95 , Issue.9 , pp. 2754-2759
    • Hill, G.R.1    Ferrara, J.L.M.2
  • 5
    • 0742270811 scopus 로고    scopus 로고
    • Pathophysiology of acute graft-versus-host disease
    • DOI 10.1002/hon.716
    • Reddy P. Pathophysiology of acute graft-versus-host disease. Hematol Oncol. 2003;21(4):149-161. (Pubitemid 38146266)
    • (2003) Hematological Oncology , vol.21 , Issue.4 , pp. 149-161
    • Reddy, P.1
  • 6
    • 77955614393 scopus 로고    scopus 로고
    • Current use and outcome of hematopoietic stem cell transplantation, Part I: CIBMTR Summary Slides, 2009
    • Pasquini M, Wang Z. Current use and outcome of hematopoietic stem cell transplantation, Part I: CIBMTR Summary Slides, 2009. CIBMTR Newslett. 2009;15(1):7-11.
    • (2009) CIBMTR Newslett , vol.15 , Issue.1 , pp. 7-11
    • Pasquini, M.1    Wang, Z.2
  • 7
    • 34250000110 scopus 로고    scopus 로고
    • Interleukin-21: A new modulator of immunity, infection, and cancer
    • DOI 10.1016/j.cytogfr.2007.04.003, PII S1359610107000378
    • Brandt K, Singh PB, Bulfone-Paus S, Ruckert R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 2007;18(3-4):223-232. (Pubitemid 46891291)
    • (2007) Cytokine and Growth Factor Reviews , vol.18 , Issue.3-4 , pp. 223-232
    • Brandt, K.1    Singh, P.B.2    Bulfone-Paus, S.3    Ruckert, R.4
  • 8
    • 45449104408 scopus 로고    scopus 로고
    • The Yin and yang of interleukin-21 in allergy, autoimmunity and cancer
    • Spolski R, Leonard WJ. The Yin and yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol. 2008;20(3):295-301.
    • (2008) Curr Opin Immunol , vol.20 , Issue.3 , pp. 295-301
    • Spolski, R.1    Leonard, W.J.2
  • 9
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • DOI 10.1146/annurev.immunol.26.021607.090316
    • Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 2008;26:57-79. (Pubitemid 351600371)
    • (2008) Annual Review of Immunology , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 10
    • 33646045626 scopus 로고    scopus 로고
    • Expression of the adaptor protein hematopoietic Src homology 2 is up-regulated in response to stimuli that promote survival and differentiation of B cells
    • Herrin BR, Justement LB. Expression of the adaptor protein hematopoietic Src homology 2 is up-regulated in response to stimuli that promote survival and differentiation of B cells. J Immunol. 2006;176(7):4163-4172. (Pubitemid 44264396)
    • (2006) Journal of Immunology , vol.176 , Issue.7 , pp. 4163-4172
    • Herrin, B.R.1    Justement, L.B.2
  • 17
    • 52349088182 scopus 로고    scopus 로고
    • IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
    • Datta S, Sarvetnick NE. IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms. PLoS ONE. 2008;3(9):e3118.
    • (2008) PLoS ONE , vol.3 , Issue.9
    • Datta, S.1    Sarvetnick, N.E.2
  • 20
    • 0030006734 scopus 로고    scopus 로고
    • IL-12 is a central mediator of acute graft-versus-host disease in mice
    • Williamson E, Garside P, Bradley JA, Mowat AM. IL-12 is a central mediator of acute graft-versus-host disease in mice. J Immunol. 1996;157(2):689-699. (Pubitemid 26231372)
    • (1996) Journal of Immunology , vol.157 , Issue.2 , pp. 689-699
    • Williamson, E.1    Garside, P.2    Bradley, J.A.3    Mowat, A.McI.4
  • 21
    • 0027716849 scopus 로고
    • Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens
    • Abhyankar S, Gilliland DG, Ferrara JL. Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens. Transplantation. 1993;56(6):1518-1523. (Pubitemid 24018815)
    • (1993) Transplantation , vol.56 , Issue.6 , pp. 1518-1523
    • Abhyankar, S.1    Gilliland, D.G.2    Ferrara, J.L.M.3
  • 22
    • 59649098784 scopus 로고    scopus 로고
    • IL-17 contributes to CD4-mediated graft-versus-host disease
    • Kappel LW, Goldberg GL, King CG, et al. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood. 2009;113(4):945-952.
    • (2009) Blood , vol.113 , Issue.4 , pp. 945-952
    • Kappel, L.W.1    Goldberg, G.L.2    King, C.G.3
  • 23
    • 63849105635 scopus 로고    scopus 로고
    • Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease
    • Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR. Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. Blood. 2009;113(10):2352-2362.
    • (2009) Blood , vol.113 , Issue.10 , pp. 2352-2362
    • Das, R.1    Chen, X.2    Komorowski, R.3    Hessner, M.J.4    Drobyski, W.R.5
  • 24
    • 73949116753 scopus 로고    scopus 로고
    • IL-21 blockade reduces graft-versus-host-disease mortality by supporting inducible T regulatory cell generation
    • Bucher C, Jasperson L, Vogtenhuber C, et al. IL-21 blockade reduces graft-versus-host-disease mortality by supporting inducible T regulatory cell generation. Blood. 2009;114(26):5375-5384.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5375-5384
    • Bucher, C.1    Jasperson, L.2    Vogtenhuber, C.3
  • 25
    • 77950599836 scopus 로고    scopus 로고
    • IL-21 is critical for GVHD in a mouse model
    • Meguro A, Ozaki K, Oh I, et al. IL-21 is critical for GVHD in a mouse model. Bone Marrow Transplant. 2009;45(4):723-729.
    • (2009) Bone Marrow Transplant , vol.45 , Issue.4 , pp. 723-729
    • Meguro, A.1    Ozaki, K.2    Oh, I.3
  • 26
    • 77956408137 scopus 로고    scopus 로고
    • Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease
    • Oh I, Ozaki K, Meguro A, et al. Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2010;185(3):1920-1926.
    • (2010) J Immunol , vol.185 , Issue.3 , pp. 1920-1926
    • Oh, I.1    Ozaki, K.2    Meguro, A.3
  • 27
    • 77955873442 scopus 로고    scopus 로고
    • Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
    • Hill GR, Olver SD, Kuns RD, et al. Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood. 2010;116(5):819-828.
    • (2010) Blood , vol.116 , Issue.5 , pp. 819-828
    • Hill, G.R.1    Olver, S.D.2    Kuns, R.D.3
  • 29
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol. 2004;173(1):657-665. (Pubitemid 38797396)
    • (2004) Journal of Immunology , vol.173 , Issue.1 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 30
    • 84856114840 scopus 로고    scopus 로고
    • Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells
    • published online ahead of print January 24, 2011 doi:10.1038/bmt.2010.342
    • Meguro A, Ozaki K, Hatanaka K, et al. Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells [published online ahead of print January 24, 2011]. Bone Marrow Transplant. doi:10.1038/bmt.2010. 342.
    • Bone Marrow Transplant
    • Meguro, A.1    Ozaki, K.2    Hatanaka, K.3
  • 31
    • 77955900102 scopus 로고    scopus 로고
    • In vivo administration of hypomethylating agents mitigate graft-versus-host disease (GvHD) without sacrificing graft-versus-leukemia (GvL)
    • Choi J, Ritchey J, Prior JL, et al. In vivo administration of hypomethylating agents mitigate graft-versus-host disease (GvHD) without sacrificing graft-versus-leukemia (GvL). Blood. 2010;116(1):129-139.
    • (2010) Blood , vol.116 , Issue.1 , pp. 129-139
    • Choi, J.1    Ritchey, J.2    Prior, J.L.3
  • 32
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • DOI 10.1038/nm915
    • Edinger M, Hoffmann P, Ermann J, et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9(9):1144-1150. (Pubitemid 37173698)
    • (2003) Nature Medicine , vol.9 , Issue.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3    Drago, K.4    Garrison, F.C.5    Strober, S.6    Negrin, R.S.7
  • 33
    • 0242557055 scopus 로고    scopus 로고
    • + T cells to allow an effective graft-versus-leukemia response
    • DOI 10.1053/bbmt.2003.50027, PII S1083879103000636
    • Jones SC, Murphy GF, Korngold R. Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transplant. 2003;9(4):243-256. (Pubitemid 40045611)
    • (2003) Biology of Blood and Marrow Transplantation , vol.9 , Issue.4 , pp. 243-256
    • Jones, S.C.1    Murphy, G.F.2    Korngold, R.3
  • 34
    • 0346690399 scopus 로고    scopus 로고
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • DOI 10.1172/JCI200317702
    • Trenado A, Charlotte F, Fisson S, et al. Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest. 2003;112(11):1688-1696. (Pubitemid 38063726)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.11 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3    Yagello, M.4    Klatzmann, D.5    Salomon, B.L.6    Cohen, J.L.7
  • 35
    • 33847189975 scopus 로고    scopus 로고
    • Increased frequencies of CD4+CD25high Tregs correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia
    • Nadal E, Garin M, Kaeda J, Apperley J, Lechler R, Dazzi F. Increased frequencies of CD4+CD25high Tregs correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia. 2007;21(3):472-479.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 472-479
    • Nadal, E.1    Garin, M.2    Kaeda, J.3    Apperley, J.4    Lechler, R.5    Dazzi, F.6
  • 36
    • 33847647528 scopus 로고    scopus 로고
    • Regulatory T cells and cancer
    • DOI 10.1016/j.coi.2007.02.004, PII S095279150700012X, Lymphocyte development/Tumour immunology
    • Wang HY, Wang R-F. Regulatory T cells and cancer. Current Opinion in Immunology. 2007;19(2):217-223. (Pubitemid 46356965)
    • (2007) Current Opinion in Immunology , vol.19 , Issue.2 , pp. 217-223
    • Wang, H.Y.1    Wang, R.-F.2
  • 37
    • 77953537389 scopus 로고    scopus 로고
    • Th17 cytokines and the gut mucosal barrier
    • Blaschitz C, Raffatellu M. Th17 cytokines and the gut mucosal barrier. J Clin Immunol. 2010;30(2):196-203.
    • (2010) J Clin Immunol , vol.30 , Issue.2 , pp. 196-203
    • Blaschitz, C.1    Raffatellu, M.2
  • 38
    • 23344442514 scopus 로고    scopus 로고
    • Lymphocyte homing to the gut: Attraction, adhesion, and commitment
    • DOI 10.1111/j.0105-2896.2005.00285.x
    • Salmi M, Jalkanen S. Lymphocyte homing to the gut: attraction, adhesion, and commitment. Immunol Rev. 2005;206:100-113. (Pubitemid 41105165)
    • (2005) Immunological Reviews , vol.206 , pp. 100-113
    • Salmi, M.1    Jalkanen, S.2
  • 41
    • 0028983485 scopus 로고
    • Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host disease
    • Tanaka T, Ohtsuka Y, Yagita H, Shiratori Y, Omata M, Okumura K. Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host disease. Int Immunol. 1995;7(8):1183-1189.
    • (1995) Int Immunol , vol.7 , Issue.8 , pp. 1183-1189
    • Tanaka, T.1    Ohtsuka, Y.2    Yagita, H.3    Shiratori, Y.4    Omata, M.5    Okumura, K.6
  • 42
    • 41949131652 scopus 로고    scopus 로고
    • Organ-derived dendritic cells have differential effects on alloreactive T cells
    • Kim TD, Terwey TH, Zakrzewski JL, et al. Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood. 2008;111(5):2929-2940.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2929-2940
    • Kim, T.D.1    Terwey, T.H.2    Zakrzewski, J.L.3
  • 44
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • DOI 10.1016/S0092-8674(00)80059-8
    • Forster R, Schubel A, Breitfeld D, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999;99(1):23-33. (Pubitemid 29468627)
    • (1999) Cell , vol.99 , Issue.1 , pp. 23-33
    • Forster, R.1    Schubel, A.2    Breitfeld, D.3    Kremmer, E.4    Renner-Muller, I.5    Wolf, E.6    Lipp, M.7
  • 45
    • 77954734137 scopus 로고    scopus 로고
    • Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells
    • Coghill JM, Carlson MJ, Panoskaltsis-Mortari A, et al. Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells. Blood. 2010;115(23):4914-4922.
    • (2010) Blood , vol.115 , Issue.23 , pp. 4914-4922
    • Coghill, J.M.1    Carlson, M.J.2    Panoskaltsis-Mortari, A.3
  • 47
    • 0035009355 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin
    • DOI 10.1034/j.1399-0012.2001.150301.x
    • Remberger M, Aschan J, Barkholt L, Tollemar J, Ringden O. Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin. Clin Transplant. 2001;15(3):147-153. (Pubitemid 32487439)
    • (2001) Clinical Transplantation , vol.15 , Issue.3 , pp. 147-153
    • Remberger, M.1    Aschan, J.2    Barkholt, L.3    Tollemar, J.4    Ringden, O.5
  • 48
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R, Kim HP, Zhu W, Levy DE, Leonard WJ. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol. 2009;182(5):2859-2867.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 50
    • 67649234772 scopus 로고    scopus 로고
    • IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    • Frohlich A, Kisielow J, Schmitz I, et al. IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009;324(5934):1576-1580.
    • (2009) Science , vol.324 , Issue.5934 , pp. 1576-1580
    • Frohlich, A.1    Kisielow, J.2    Schmitz, I.3
  • 51
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324(5934):1572-1576.
    • (2009) Science , vol.324 , Issue.5934 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 52
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science. 2009;324(5934):1569-1572.
    • (2009) Science , vol.324 , Issue.5934 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 53
    • 0023134746 scopus 로고
    • Interferon alpha/beta synthesis during acute graft-versus-host disease
    • Reyes VE, Klimpel GR. Interferon alpha/beta synthesis during acute graft-versus-host disease. Transplantation. 1987;43(3):412-416. (Pubitemid 17044754)
    • (1987) Transplantation , vol.43 , Issue.3 , pp. 412-416
    • Reyes, V.E.1    Klimpel, G.R.2
  • 54
    • 3442901047 scopus 로고    scopus 로고
    • IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells
    • DOI 10.1189/jlb.1003488
    • Strengell M, Julkunen I, Matikainen S. IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. J Leukoc Biol. 2004;76(2):416-422. (Pubitemid 39006956)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.2 , pp. 416-422
    • Strengell, M.1    Julkunen, I.2    Matikainen, S.3


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