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Volumn 86, Issue SUPPL. 1, 2012, Pages 36-44

Topical therapies in inflammatory bowel disease

Author keywords

Aminosalicylates; Enema; Foam; Topical therapy; Ulcerative colitis

Indexed keywords

ACETYLSALICYLIC ACID PLUS BUTALBITAL PLUS CAFFEINE; ALICAFORSEN; ARSENIC; ASALEX; ASAMAX; ASAVIXIN; ASAZINE; BECLOENEMA; BECLOMETHASON; BETAMETHASONE SODIUM PHOSPHATE; BUDENOFALK; BUDESONIDE; BUDO SAN; BUTYRIC ACID; COLITAN; CROHNAX; CYCLOSPORIN; ENEMA; ENTERAPROCT; ENTOCORD; HYDROCORTISONE; HYDROCORTISONE ACETATE; LABOXANTRYL; LOPERAMIDE; MESALAZINE; NEOPROCT; NICOTINE; PENTACOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; PRED KLYSMA; PREDENEMA; PREDNISOLONE; PREDNISOLONE 3 SULFOBENZOATE; PREDNISOLONE SODIUM PHOSPHATE; PROBIOTIC AGENT; PROCTOSTEROID; QUADRASA; QUOTA; SALAZOSULFAPYRIDINE; SCHERIPROCT; TACROLIMUS; TETRAHYDROLIPSTATIN; TIXOCORTOL PIVALATE; ULTRAPROCT; UNCLASSIFIED DRUG;

EID: 84867542665     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000341947     Document Type: Article
Times cited : (30)

References (63)
  • 2
    • 41949134167 scopus 로고    scopus 로고
    • Ulcerative proctitis: A review of pharmacotherapy and management
    • Lakatos PL, Lakatos L: Ulcerative proctitis: a review of pharmacotherapy and management. Expert Opin Pharmacot her 2008; 9: 741-749.
    • (2008) Expert Opin Pharmacot Her , vol.9 , pp. 741-749
    • Lakatos, P.L.1    Lakatos, L.2
  • 3
    • 70449476259 scopus 로고    scopus 로고
    • Medical management of ulcerative colitis
    • Rogler G: Medical management of ulcerative colitis. Dig Dis 2009; 27:542-549.
    • (2009) Dig Dis , vol.27 , pp. 542-549
    • Rogler, G.1
  • 5
    • 0032877403 scopus 로고    scopus 로고
    • Practicality of 5-aminosalicylic suppositories for long-term treatment of inactive distal ulcerative colitis
    • Casellas F, Vaquero E, Armengol JR, Malage-lada JR: Practicality of 5-aminosalicylic suppositories for long-term treatment of inactive distal ulcerative colitis. Hepatogastroen-terology 1999; 46: 2343-2346.
    • (1999) Hepatogastroen-terology , vol.46 , pp. 2343-2346
    • Casellas, F.1    Vaquero, E.2    Armengol, J.R.3    Malage-Lada, J.R.4
  • 9
    • 79953696521 scopus 로고    scopus 로고
    • Review article: Delivery and efficacy of topical 5-aminosali-cylic acid (mesalazine) therapy in the treatment of ulcerative colitis
    • Harris MS, Lichtenstein GR: Review article: delivery and efficacy of topical 5-aminosali-cylic acid (mesalazine) therapy in the treatment of ulcerative colitis. Aliment Pharmacol Ther 2011; 33:996-1009.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 996-1009
    • Harris, M.S.1    Lichtenstein, G.R.2
  • 10
    • 0025049819 scopus 로고
    • 5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosig-moiditis: A double-blind placebo-controlled clinical trial
    • D'Arienzo A, Panarese A, D'Armiento FP, Lancia C, Quattrone P, Giannattasio F, Boscaino A, Mazzacca G: 5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosig-moiditis: a double-blind placebo-controlled clinical trial. Am J Gastroenterol 1990; 85: 1079-1082.
    • (1990) Am J Gastroenterol , vol.85 , pp. 1079-1082
    • D'Arienzo, A.1    Panarese, A.2    D'Armiento, F.P.3    Lancia, C.4    Quattrone, P.5    Giannattasio, F.6    Boscaino, A.7    Mazzacca, G.8
  • 13
    • 0029044783 scopus 로고
    • Rectal aminosalicy-late therapy for distal ulcerative colitis: A me-ta-analysis. A liment
    • Marshall JK, Irvine EJ: Rectal aminosalicy-late therapy for distal ulcerative colitis: a me-ta-analysis. A liment Pharmacol Ther 1995; 9: 293-300.
    • (1995) Pharmacol Ther , vol.9 , pp. 293-300
    • Marshall, J.K.1    Irvine, E.J.2
  • 14
    • 0030848283 scopus 로고    scopus 로고
    • Rectal corticoste-roids versus alternative treatments in ulcer-ative colitis: A meta-analysis
    • Marshall JK, Irvine EJ: Rectal corticoste-roids versus alternative treatments in ulcer-ative colitis: a meta-analysis. Gut 1997; 40: 775-781.
    • (1997) Gut , vol.40 , pp. 775-781
    • Marshall, J.K.1    Irvine, E.J.2
  • 15
    • 0029901887 scopus 로고    scopus 로고
    • Beclo-methasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus t he combination of both (3 mg/2 g) as retent ion enemas in active ulcerative proctitis
    • Mulder CJ, Fockens P, Meijer JW, van der Heide H, Wiltink EH, Tytgat GN: Beclo-methasone dipropionate (3 mg) versus 5-aminosalicyl ic acid (2 g) versus t he combination of both (3 mg/2 g) as retent ion enemas in active ulcerative proctitis. Eur J Gastroen-terol Hepatol 1996; 8: 549-553.
    • (1996) Eur J Gastroen-terol Hepatol , vol.8 , pp. 549-553
    • Mulder, C.J.1    Fockens, P.2    Meijer, J.W.3    Van Der Heide, H.4    Wiltink, E.H.5    Tytgat, G.N.6
  • 17
    • 21044433011 scopus 로고    scopus 로고
    • Combined oral and enema treatment with Pentasa (mesala-zine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: A randomised, double blind, placebo controlled study
    • Marteau P, Probert CS, Lindgren S, Gassul M, Tan TG, Dignass A, Befrits R, Midhagen G, Rademaker J, Foldager M: Combined oral and enema treatment with Pentasa (mesala-zine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study. Gut 2005; 54: 960-965.
    • (2005) Gut , vol.54 , pp. 960-965
    • Marteau, P.1    Probert, C.S.2    Lindgren, S.3    Gassul, M.4    Tan, T.G.5    Dignass, A.6    Befrits, R.7    Midhagen, G.8    Rademaker, J.9    Foldager, M.10
  • 18
    • 0025359098 scopus 로고
    • Intermittent therapy with high-dose 5-aminosalicylic acid enemas for maintaining remission in ul-cerative proctosigmoiditis
    • d'Albasio G, Trallori G, Ghetti A, Milla M, Nucci A, Pacini F, Morettini A: Intermittent therapy with high-dose 5-aminosalicylic acid enemas for maintaining remission in ul-cerative proctosigmoiditis. Dis Colon Rectum 1990; 33: 394-397.
    • (1990) Dis Colon Rectum , vol.33 , pp. 394-397
    • D'Albasio, G.1    Trallori, G.2    Ghetti, A.3    Milla, M.4    Nucci, A.5    Pacini, F.6    Morettini, A.7
  • 19
    • 0031899851 scopus 로고    scopus 로고
    • Use of mesalazine slow release suppositories 1 g three times per week to maintain remission of ulcerative proctitis: A randomised double blind placebo controlled multicentre study
    • Marteau P, Crand J, Foucault M, Rambaud JC: Use of mesalazine slow release suppositories 1 g three times per week to maintain remission of ulcerative proctitis: a randomised double blind placebo controlled multicentre study. Gut 1998; 42: 195-199.
    • (1998) Gut , vol.42 , pp. 195-199
    • Marteau, P.1    Crand, J.2    Foucault, M.3    Rambaud, J.C.4
  • 20
    • 73949159228 scopus 로고    scopus 로고
    • Importance of mucosal healing in ulcerative colitis
    • Lichtenstein GR, Rutgeerts P: Importance of mucosal healing in ulcerative colitis. In-flamm Bowel Dis 2010; 16:338-346.
    • (2010) Flamm Bowel Dis , vol.16 , pp. 338-346
    • Lichtenstein, G.R.1    Rutgeerts, P.2
  • 21
    • 84867578354 scopus 로고    scopus 로고
    • High Mucosal Healing Rates in 5-ASA-treated ulcerative colitis patients: Results of a meta-analysis of clinical trials
    • Romkens TE, Kampschreur MT, Drenth JP, van Oijen MG, de Jong DJ: High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials. Inflamm Bowel Dis 2012.
    • (2012) Inflamm Bowel Dis
    • Romkens, T.E.1    Kampschreur, M.T.2    Drenth, J.P.3    Van Oijen, M.G.4    De Jong, D.J.5
  • 22
    • 80052464275 scopus 로고    scopus 로고
    • Early symptomatic response and mucosal healing w ith mesa la zi ne recta l su spension t herapy in active distal ulcerative colitis-additional results from two controlled studies
    • Sandborn WJ, Hanauer S, Lichtenstein GR, Safdi M, Edeline M, Scott Harris M: Early symptomatic response and mucosal healing w ith mesa la zi ne recta l su spension t herapy in active distal ulcerative colitis-additional results from two controlled studies. Aliment Pharmacol Ther 2011; 34: 747-756.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 747-756
    • Sandborn, W.J.1    Hanauer, S.2    Lichtenstein, G.R.3    Safdi, M.4    Edeline, M.5    Scott Harris, M.6
  • 23
    • 58749117272 scopus 로고    scopus 로고
    • Rectal perforation in ulcerative colitis: Complication of an enema tip
    • disc 344
    • Tanswell IJ, Irfan K, Kossakowski T, Town-son G: Rectal perforation in ulcerative colitis: complication of an enema tip. Gastroin-test Endosc 2009; 69:344;disc 344.
    • (2009) Gastroin-test Endosc , vol.69 , pp. 344
    • Tanswell, I.J.1    Irfan, K.2    Kossakowski, T.3    Town-Son, G.4
  • 24
    • 8844258136 scopus 로고    scopus 로고
    • Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease
    • Klotz U, Schwab M: Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease. Adv Drug Deliv Rev 2005; 57: 267-279.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 267-279
    • Klotz, U.1    Schwab, M.2
  • 25
    • 0026570382 scopus 로고
    • A steroid enema, budesonide, lacking systemic effects for the treatment of distal ulcerative colitis or proctitis
    • Danielsson A, Lofberg R, Persson T, Salde L, Schioler R, Suhr O, Willen R: A steroid enema, budesonide, lacking systemic effects for the treatment of distal ulcerative colitis or proctitis. Scand J Gastroenterol 1992; 27: 9-12.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 9-12
    • Danielsson, A.1    Lofberg, R.2    Persson, T.3    Salde, L.4    Schioler, R.5    Suhr, O.6    Willen, R.7
  • 27
    • 0032248024 scopus 로고    scopus 로고
    • Acute adrenal insufficiency after stopping prolonged corticotherapy with betnesol enemas for ulcerative colitis (article in French)
    • Bili H, Algayres JP, Revel F, Coutant G, Daly JP: Acute adrenal insufficiency after stopping prolonged corticotherapy with betnesol enemas for ulcerative colitis (article in French). Gastroenterol Clin Biol 1998; 22: 1113-1114.
    • (1998) Gastroenterol Clin Biol , vol.22 , pp. 1113-1114
    • Bili, H.1    Algayres, J.P.2    Revel, F.3    Coutant, G.4    Daly, J.P.5
  • 28
    • 34249100276 scopus 로고    scopus 로고
    • 5-Ami-nosalicylates and renal function in inflammatory bowel disease: A systematic review
    • Gisbert JP, Gonzalez-Lama Y, Mate J: 5-Ami-nosalicylates and renal function in inflammatory bowel disease: a systematic review. Inf lamm Bowel Dis 2007; 13: 629-638.
    • (2007) Inf Lamm Bowel Dis , vol.13 , pp. 629-638
    • Gisbert, J.P.1    Gonzalez-Lama, Y.2    Mate, J.3
  • 29
    • 33847723392 scopus 로고    scopus 로고
    • The risks and the benefits of mesalazine as a treatment for ul-cerative colitis
    • Moss AC, Peppercorn MA: The risks and the benefits of mesalazine as a treatment for ul-cerative colitis. Expert Opin Drug Saf 2007; 6: 99-107.
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 99-107
    • Moss, A.C.1    Peppercorn, M.A.2
  • 30
    • 58149096349 scopus 로고    scopus 로고
    • A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis
    • Kim KH, Kim TN, Jang BI: A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis. Korean J Gastroenterol 2007; 50: 379-383.
    • (2007) Korean J Gastroenterol , vol.50 , pp. 379-383
    • Kim, K.H.1    Kim, T.N.2    Jang, B.I.3
  • 31
    • 0034602358 scopus 로고    scopus 로고
    • Acute pancreat it is-adverse effect of 5-aminosalicylic acid (me-salazine) in various galenic dosage forms
    • Schworer H, Ramadori G: Acute pancreat it is-adverse effect of 5-aminosalicylic acid (me-salazine) in various galenic dosage forms. Dtsch Med Wochenschr 2000; 125: 1328-1330.
    • (2000) Dtsch Med Wochenschr , vol.125 , pp. 1328-1330
    • Schworer, H.1    Ramadori, G.2
  • 32
    • 0034798909 scopus 로고    scopus 로고
    • Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis
    • Kane SV, Cohen RD, Aikens JE, Hanauer SB: Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis. Am J Gastroenterol 2001; 96:2929-2933.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2929-2933
    • Kane, S.V.1    Cohen, R.D.2    Aikens, J.E.3    Hanauer, S.B.4
  • 34
    • 0037245392 scopus 로고    scopus 로고
    • Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis
    • Kane SV, Huo D, Aikens J, Hanauer SB: Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med 2003; 114:39-43.
    • (2003) Am J Med , vol.114 , pp. 39-43
    • Kane, S.V.1    Huo, D.2    Aikens, J.3    Hanauer, S.B.4
  • 36
    • 33644995445 scopus 로고    scopus 로고
    • Systematic review: Adherence issues in the treatment of ulcerative colitis
    • Kane SV: Systematic review: adherence issues in the treatment of ulcerative colitis. Aliment Pharmacol Ther 2006; 23: 577-585.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 577-585
    • Kane, S.V.1
  • 37
    • 39549091909 scopus 로고    scopus 로고
    • The challenge of compliance and persistence: Focus on ulcerative colitis
    • quiz s13-s15
    • Kane SV, Brixner D, Rubin DT, Sewitch MJ: The challenge of compliance and persistence: focus on ulcerative colitis. J Manag Care Pharm 2008; 14:s2-s12;quiz s13-s15.
    • (2008) J Manag Care Pharm , vol.14
    • Kane, S.V.1    Brixner, D.2    Rubin, D.T.3    Sewitch, M.J.4
  • 38
    • 43749118171 scopus 로고    scopus 로고
    • Improving delivery of aminosalicylates in ulcerative colitis: Effect on patient outcomes
    • Fernandez-Becker NQ, Moss AC: Improving delivery of aminosalicylates in ulcerative colitis: effect on patient outcomes. Drugs 2008; 68:1089-1103.
    • (2008) Drugs , vol.68 , pp. 1089-1103
    • Fernandez-Becker, N.Q.1    Moss, A.C.2
  • 39
    • 72049085802 scopus 로고    scopus 로고
    • 5-ASA in ulcerative colitis: Improving treatment compliance
    • Prantera C, Rizzi M: 5-ASA in ulcerative colitis: improving treatment compliance. World J Gastroenterol 2009; 15:4353-4355.
    • (2009) World J Gastroenterol , vol.15 , pp. 4353-4355
    • Prantera, C.1    Rizzi, M.2
  • 42
    • 0024469950 scopus 로고
    • Anorectal manometry in active and quiescent ulcerative colitis
    • Loening-Baucke V, Metcalf AM, Shirazi S: Anorectal manometry in active and quiescent ulcerative colitis. Am J Gastroenterol 1989; 84:892-897.
    • (1989) Am J Gastroenterol , vol.84 , pp. 892-897
    • Loening-Baucke, V.1    Metcalf, A.M.2    Shirazi, S.3
  • 43
    • 0023635765 scopus 로고
    • Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis
    • Rao SS, Read NW, Davison PA, Bannister JJ, Holdsworth CD: Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis. Gastroenterology 1987; 93: 1270-1275.
    • (1987) Gastroenterology , vol.93 , pp. 1270-1275
    • Rao, S.S.1    Read, N.W.2    Davison, P.A.3    Bannister, J.J.4    Holdsworth, C.D.5
  • 44
    • 0019946185 scopus 로고
    • Rectal pressure and rectal compliance in ulcerative colitis
    • Suzuki H, Fujioka M: Rectal pressure and rectal compliance in ulcerative colitis. Jpn J Surg 1982; 12: 79-81.
    • (1982) Jpn J Surg , vol.12 , pp. 79-81
    • Suzuki, H.1    Fujioka, M.2
  • 45
    • 23944507601 scopus 로고    scopus 로고
    • The effects of loperamide on continence problems and anorectal function in obese subjects taking orlistat
    • Fox M, Stutz B, Menne D, Fried M, Schwizer W, Thumshirn M: The effects of loperamide on continence problems and anorectal function in obese subjects taking orlistat. Dig Dis Sci 2005; 50:1576-1583.
    • (2005) Dig Dis Sci , vol.50 , pp. 1576-1583
    • Fox, M.1    Stutz, B.2    Menne, D.3    Fried, M.4    Schwizer, W.5    Thumshirn, M.6
  • 46
    • 77958150861 scopus 로고    scopus 로고
    • Adherence of gastroenterolo-gists to European Crohn's and Colitis Organisation consensus on ulcerative colitis: A real-life survey in Spain
    • Gisbert JP, Gomollon F, Hinojosa J, Lopez San Roman A: Adherence of gastroenterolo-gists to European Crohn's and Colitis Organisation consensus on ulcerative colitis: a real-life survey in Spain. J Crohn Colitis 2010; 4: 567-574.
    • (2010) J Crohn Colitis , vol.4 , pp. 567-574
    • Gisbert, J.P.1    Gomollon, F.2    Hinojosa, J.3    Lopez San Roman, A.4
  • 49
    • 77950797408 scopus 로고    scopus 로고
    • Clinical trial: Probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN)
    • Matthes H, Krummenerl T, Giensch M, Wolff C, Schulze J: Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN). BMC Complement Altern Med 2010; 10: 13.
    • (2010) BMC Complement Altern Med , vol.10 , pp. 13
    • Matthes, H.1    Krummenerl, T.2    Giensch, M.3    Wolff, C.4    Schulze, J.5
  • 50
    • 0024498413 scopus 로고
    • Treatment of ulcer-ative colitis by implantation of normal co-lonic f lora
    • Bennet JD, Brinkman M: Treatment of ulcer-ative colitis by implantation of normal co-lonic f lora. Lancet 1989; 1(8630).
    • (1989) Lancet , vol.1 , pp. 8630
    • Bennet, J.D.1    Brinkman, M.2
  • 51
    • 80155182168 scopus 로고    scopus 로고
    • Fecal microbiota transplantation: Current status and future directions
    • Borody TJ, Campbell J: Fecal microbiota transplantation: current status and future directions. Expert Rev Gastroenterol Hepa-tol 2011; 5:653-655.
    • (2011) Expert Rev Gastroenterol Hepa-tol , vol.5 , pp. 653-655
    • Borody, T.J.1    Campbell, J.2
  • 53
    • 54049121762 scopus 로고    scopus 로고
    • Rectal tacroli-mus in the treatment of resistant ulcerative proctitis
    • Lawrance IC, Copeland TS: Rectal tacroli-mus in the treatment of resistant ulcerative proctitis. Aliment Pharmacol Ther 2008; 28: 1214-1220.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 1214-1220
    • Lawrance, I.C.1    Copeland, T.S.2
  • 55
    • 33646237136 scopus 로고    scopus 로고
    • Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis
    • Miner PB Jr, Geary RS, Matson J, Chuang E, Xia S, Baker BF, Wedel MK: Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis. A liment Pharmacol Ther 2006; 23: 1427-1434.
    • (2006) A Liment Pharmacol Ther , vol.23 , pp. 1427-1434
    • Miner Jr., P.B.1    Geary, R.S.2    Matson, J.3    Chuang, E.4    Xia, S.5    Baker, B.F.6    Wedel, M.K.7
  • 56
    • 1342331543 scopus 로고    scopus 로고
    • An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion mole-cule-1, in the treatment of chronic, unremitting pouchitis
    • Miner P, Wedel M, Bane B, Bradley J: An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion mole-cule-1, in the treatment of chronic, unremitting pouchitis. Aliment Pharmacol Ther 2004; 19: 281-286.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 281-286
    • Miner, P.1    Wedel, M.2    Bane, B.3    Bradley, J.4
  • 60
    • 0029846450 scopus 로고    scopus 로고
    • Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial. German-Austrian SCFA Study Group
    • Scheppach W: Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial. German-Austrian SCFA Study Group. Dig Dis Sci 1996; 41: 2254-2259.
    • (1996) Dig Dis Sci , vol.41 , pp. 2254-2259
    • Scheppach, W.1
  • 61
    • 77954425357 scopus 로고    scopus 로고
    • Topical rosigli-tazone treatment improves ulcerative colitis by restoring peroxisome proliferator-acti-vated receptor-gamma activity
    • Pedersen G, Brynskov J: Topical rosigli-tazone treatment improves ulcerative colitis by restoring peroxisome proliferator-acti-vated receptor-gamma activity. Am J Gastroenterol 2010; 105:1595-1603.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1595-1603
    • Pedersen, G.1    Brynskov, J.2


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