A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue

Science Translational Medicine

Volumn 4, Issue 149, 2012, Pages

  Nance, Elizabeth A ^a,b   Woodworth, Graeme F ^a,c   Sailor, Kurt A ^c   Shih, Ting Yu ^b   Xu, Qingguo ^a   Swaminathan, Ganesh ^b   Xiang, Dennis ^b   Eberhart, Charles ^a   Hanes, Justin ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; MACROGOL; NANOPARTICLE; PACLITAXEL; POLYGLACTIN; QUANTUM DOT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN SLICE; BRAIN TISSUE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG PENETRATION; EX VIVO STUDY; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; ZETA POTENTIAL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHEMISTRY, PHARMACEUTICAL; COATED MATERIALS, BIOCOMPATIBLE; DIFFUSION; DRUG CARRIERS; FEMALE; HUMANS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; NANOPARTICLES; NANOTECHNOLOGY; PACLITAXEL; PARTICLE SIZE; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYSTYRENES; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TIME FACTORS;

EID: 84865820981     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003594     Document Type: Article

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