Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa - A first in vivo study in human patients

Journal of Controlled Release

Volumn 165, Issue 2, 2013, Pages 139-145

  Schmidt, Carsten ^a   Lautenschlaeger, Christian ^a   Collnot, Eva Maria ^b,c   Schumann, Michael ^d   Bojarski, Christian ^d   Schulzke, Jörg Dieter ^d   Lehr, Claus Michael ^b,c   Stallmach, Andreas ^a  

^a University Clinic Jena   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Crohn's disease; Human; In vivo; Microparticles; Nanoparticles; Ulcerative colitis

Indexed keywords

CROHN'S DISEASE; HUMAN; IN-VIVO; MICRO-PARTICLES; ULCERATIVE COLITIS;

DRUG DELIVERY; DRUG INTERACTIONS; NANOPARTICLES;

DISEASES;

NANOPARTICLE; POLYVINYL ALCOHOL; RESOMER;

ADULT; AGED; ARTICLE; BIOACCUMULATION; BIODEGRADABILITY; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CROHN DISEASE; DRUG EFFICACY; DRUG TARGETING; DRUG TRANSPORT; ENTERITIS; EX VIVO STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INTESTINE MUCOSA; MALE; PARTICLE SIZE; PRIORITY JOURNAL; RECTUM BIOPSY; RECTUM MUCOSA; SCANNING ELECTRON MICROSCOPY; ULCERATIVE COLITIS;

ADULT; AGED; COLITIS, ULCERATIVE; COLON; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NANOPARTICLES; RECTUM; YOUNG ADULT;

EID: 84870685434     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.019     Document Type: Article

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