메뉴 건너뛰기




Volumn 230, Issue 1, 2015, Pages 116-130

Human olfactory bulb neural stem cells expressing hNGF restore cognitive deficit in Alzheimer's disease rat model

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; IBOTENIC ACID; NERVE GROWTH FACTOR;

EID: 84910068058     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24688     Document Type: Article
Times cited : (43)

References (97)
  • 1
    • 0028786849 scopus 로고
    • Paired helical filament-like phosphorylation of tau, deposition of (beta)/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A
    • Arendt T, Holzer M, Fruth R, Bruckner MK, Gartner U. 1995. Paired helical filament-like phosphorylation of tau, deposition of (beta)/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience 69:691-698.
    • (1995) Neuroscience , vol.69 , pp. 691-698
    • Arendt, T.1    Holzer, M.2    Fruth, R.3    Bruckner, M.K.4    Gartner, U.5
  • 3
    • 0034032642 scopus 로고    scopus 로고
    • Cell replacement therapies for central nervous system disorders
    • Björklund A, Lindvall O. 2000. Cell replacement therapies for central nervous system disorders. Nat Neurosci 3:537-544.
    • (2000) Nat Neurosci , vol.3 , pp. 537-544
    • Björklund, A.1    Lindvall, O.2
  • 4
    • 0032517186 scopus 로고    scopus 로고
    • Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease
    • Bobinski MDE, Leon MJ, Tarnawski M, Wegiel J, Reisberg B, Miller DC, Wisniewski HM. 1998. Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain Res 805:267-269.
    • (1998) Brain Res , vol.805 , pp. 267-269
    • Bobinski, M.D.E.1    Leon, M.J.2    Tarnawski, M.3    Wegiel, J.4    Reisberg, B.5    Miller, D.C.6    Wisniewski, H.M.7
  • 5
    • 0030273384 scopus 로고    scopus 로고
    • Neuronal progenitors as tools for cell replacement in the nervous system
    • Brustle O, McKay RG. 1996. Neuronal progenitors as tools for cell replacement in the nervous system. Curr Opin Neurobiol 6:688-695.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 688-695
    • Brustle, O.1    McKay, R.G.2
  • 6
    • 0031434399 scopus 로고    scopus 로고
    • In vitro generated neural precursors participate in mammalian brain development
    • Brustle O, Spiro A, Karram K, Choudhary K. 1997. In vitro generated neural precursors participate in mammalian brain development. Proc Natl Acad Sci USA 94:14809-14814.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14809-14814
    • Brustle, O.1    Spiro, A.2    Karram, K.3    Choudhary, K.4
  • 7
    • 0029240724 scopus 로고
    • Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiate in vitro
    • Buc-Caron H. 1995. Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiate in vitro. Neurobiol Dis 2:37-47.
    • (1995) Neurobiol Dis , vol.2 , pp. 37-47
    • Buc-Caron, H.1
  • 8
    • 0038809051 scopus 로고    scopus 로고
    • Neural stem cells and cholinergic neurons:regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor
    • Calza L, Giuliani A, Fernandez M, et al. 2003. Neural stem cells and cholinergic neurons:regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. Proc Natl Acad Sci USA 100:7325-7330.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7325-7330
    • Calza, L.1    Giuliani, A.2    Fernandez, M.3
  • 9
    • 84887212382 scopus 로고    scopus 로고
    • Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1
    • Casalbore P, Budoni M, Ricci-Vitiani L, Cenciarelli C, Petrucci G. 2009. Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1. PLoS One 4:e4434.
    • (2009) PLoS One , vol.4 , pp. e4434
    • Casalbore, P.1    Budoni, M.2    Ricci-Vitiani, L.3    Cenciarelli, C.4    Petrucci, G.5
  • 10
    • 33746561758 scopus 로고    scopus 로고
    • In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system
    • Cenciarelli C, Budoni M, Mercanti D, Fernandez E, Pallini R. 2006. In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system. Neurol Res 28:505-512.
    • (2006) Neurol Res , vol.28 , pp. 505-512
    • Cenciarelli, C.1    Budoni, M.2    Mercanti, D.3    Fernandez, E.4    Pallini, R.5
  • 11
    • 0028965223 scopus 로고
    • Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration
    • Chen KS, Gage FH. 1995. Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration. J Neurosci 15:2819-2825.
    • (1995) J Neurosci , vol.15 , pp. 2819-2825
    • Chen, K.S.1    Gage, F.H.2
  • 12
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists
    • Choi DW, Koh J, Peters YS. 1988. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 8:185-196.
    • (1988) J Neurosci , vol.8 , pp. 185-196
    • Choi, D.W.1    Koh, J.2    Peters, Y.S.3
  • 14
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, DeLong MR. 1983. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science:219:1190.
    • (1983) Science , vol.219 , pp. 1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 15
    • 0025938569 scopus 로고
    • The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions
    • Dunnett SB, Everitt BJ, Robbins TW. 1991. The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions. Trends Neurosci 14: 494-501.
    • (1991) Trends Neurosci , vol.14 , pp. 494-501
    • Dunnett, S.B.1    Everitt, B.J.2    Robbins, T.W.3
  • 17
    • 84655161566 scopus 로고    scopus 로고
    • Optimal time for passaging neurospheres based on primary neural stem cell cultures
    • Fangling X, Huasong G, Yilu G. 2011. Optimal time for passaging neurospheres based on primary neural stem cell cultures. Cytotechnology 63:621-631.
    • (2011) Cytotechnology , vol.63 , pp. 621-631
    • Fangling, X.1    Huasong, G.2    Yilu, G.3
  • 18
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fischer W, Wictorin K, Bjorklund A, Williams LR, Varon S, Gage FH. 1987. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329:65-68.
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Bjorklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 20
    • 0031463865 scopus 로고    scopus 로고
    • Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-D-aspartate receptor-dependent long-term potentiation on contextual processing in rats
    • Good M, Bannerman D. 1997. Differential effects of ibotenic acid lesions of the hippocampus and blockade of N-methyl-D-aspartate receptor-dependent long-term potentiation on contextual processing in rats. Behav Neurosci 111:1171-1183.
    • (1997) Behav Neurosci , vol.111 , pp. 1171-1183
    • Good, M.1    Bannerman, D.2
  • 21
    • 0019818469 scopus 로고
    • No detectable remote lesions following massive intrastriatal injections of ibotenic acid
    • Guldin WO, Markowitsch HJ. 1981. No detectable remote lesions following massive intrastriatal injections of ibotenic acid. Brain Res 225:446-451.
    • (1981) Brain Res , vol.225 , pp. 446-451
    • Guldin, W.O.1    Markowitsch, H.J.2
  • 22
    • 0020060682 scopus 로고
    • Epidural kainate, but not ibotenate, produces lesions in local and distant regions of the brain. A comparison of the intracerebral actions of kainic acid and ibotenic acid
    • Guldin WO, Markowitsch HJ. 1982. Epidural kainate, but not ibotenate, produces lesions in local and distant regions of the brain. A comparison of the intracerebral actions of kainic acid and ibotenic acid. J Neurosci Methods 5:83-93.
    • (1982) J Neurosci Methods , vol.5 , pp. 83-93
    • Guldin, W.O.1    Markowitsch, H.J.2
  • 23
    • 0022486717 scopus 로고
    • Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection
    • Hefti F. 1986. Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection. J Neurosci 6:2155-2162.
    • (1986) J Neurosci , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 24
    • 33746580678 scopus 로고    scopus 로고
    • Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells
    • Hermann A, Maisel M, Liebau S, et al. 2006. Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells. J Neurochem 98:629-640.
    • (2006) J Neurochem , vol.98 , pp. 629-640
    • Hermann, A.1    Maisel, M.2    Liebau, S.3
  • 25
    • 0034718896 scopus 로고    scopus 로고
    • Regenerating the damaged central nervous system
    • Horner PJ, Gage PH. 2000. Regenerating the damaged central nervous system. Nature 407:963-970.
    • (2000) Nature , vol.407 , pp. 963-970
    • Horner, P.J.1    Gage, P.H.2
  • 26
    • 80555143329 scopus 로고    scopus 로고
    • Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair
    • Hwang DH, Kim HM, Kang YM, Joo IS, Cho CS. 2011. Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair. Cell Transplant 20:1361-1379.
    • (2011) Cell Transplant , vol.20 , pp. 1361-1379
    • Hwang, D.H.1    Kim, H.M.2    Kang, Y.M.3    Joo, I.S.4    Cho, C.S.5
  • 27
    • 70350167840 scopus 로고    scopus 로고
    • Intrathecal transplantation of human neural stem cells over-expressing VEGF provides behavioral improvement, disease onset delay and survival extension in transgenic ALS mice
    • Hwang DH, Lee HJ, Seok JI, Kim BG, Joo IS, Kim SU. 2009. Intrathecal transplantation of human neural stem cells over-expressing VEGF provides behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther 16:1234-1244.
    • (2009) Gene Ther , vol.16 , pp. 1234-1244
    • Hwang, D.H.1    Lee, H.J.2    Seok, J.I.3    Kim, B.G.4    Joo, I.S.5    Kim, S.U.6
  • 28
    • 19944426191 scopus 로고    scopus 로고
    • Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/ CXC chemokinem receptor 4 pathway
    • Imitola J, Raddassi K, Park KI, Mueller J, Nieto M. 2004. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/ CXC chemokinem receptor 4 pathway. Proc Natl Acad Sci USA 101:18117-18122.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 18117-18122
    • Imitola, J.1    Raddassi, K.2    Park, K.I.3    Mueller, J.4    Nieto, M.5
  • 29
    • 0021076636 scopus 로고
    • Selective hippocampal lesions and behavior: Effects of kainic acid lesions on performance of place and cue tasks
    • Jarrard LE. 1983. Selective hippocampal lesions and behavior: Effects of kainic acid lesions on performance of place and cue tasks. Behav Neurosci 97:873-889.
    • (1983) Behav Neurosci , vol.97 , pp. 873-889
    • Jarrard, L.E.1
  • 30
    • 0033534379 scopus 로고    scopus 로고
    • Identification of a neural stem cell in the adult mammalian central nervous system
    • Johansson CB, Momma S, Clarke DL, et al. 1999. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96:25-34.
    • (1999) Cell , vol.96 , pp. 25-34
    • Johansson, C.B.1    Momma, S.2    Clarke, D.L.3
  • 31
    • 0027140984 scopus 로고
    • Regulation of dopamine production by genetically modified primary fibroblasts
    • Kang UJ, Fisher LJ, Joh TH, O'Malley KL, Gage FH. 1993. Regulation of dopamine production by genetically modified primary fibroblasts. J Neurosci 13:5203-5211.
    • (1993) J Neurosci , vol.13 , pp. 5203-5211
    • Kang, U.J.1    Fisher, L.J.2    Joh, T.H.3    O'Malley, K.L.4    Gage, F.H.5
  • 32
    • 69249220421 scopus 로고    scopus 로고
    • Stem cell-based cell therapy in neurological diseases: A review
    • Kim S, deVellis UJ. 2009. Stem cell-based cell therapy in neurological diseases: A review. J Neurosci Res 87:2183-2200.
    • (2009) J Neurosci Res , vol.87 , pp. 2183-2200
    • Kim, S.1    deVellis, U.J.2
  • 33
    • 33645512055 scopus 로고    scopus 로고
    • Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    • Kim SU, Park IH, Kim TH, Kim KS, Choi HB. 2006. Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology 26:129-140.
    • (2006) Neuropathology , vol.26 , pp. 129-140
    • Kim, S.U.1    Park, I.H.2    Kim, T.H.3    Kim, K.S.4    Choi, H.B.5
  • 34
    • 4644224829 scopus 로고    scopus 로고
    • Human neural stem cells genetically modified for brain repair in neurological disorders
    • Kim SU. 2004. Human neural stem cells genetically modified for brain repair in neurological disorders. Neuropathology 24:159-174.
    • (2004) Neuropathology , vol.24 , pp. 159-174
    • Kim, S.U.1
  • 35
    • 0028596086 scopus 로고
    • In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain
    • Kirschenbaum B, Nedergaard M, Preuss A, et al. 1994. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb Cortex 4:576-589.
    • (1994) Cereb Cortex , vol.4 , pp. 576-589
    • Kirschenbaum, B.1    Nedergaard, M.2    Preuss, A.3
  • 36
    • 0018595603 scopus 로고
    • Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid
    • Köhler C, Schwarcz R, Fuxe K. 1979. Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid. Neurosci Lett 15:223-228.
    • (1979) Neurosci Lett , vol.15 , pp. 223-228
    • Köhler, C.1    Schwarcz, R.2    Fuxe, K.3
  • 38
    • 0028020905 scopus 로고
    • The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor
    • Kordower JH, Winn SR, Liu SR, Mufson EJ, Sladek JR, et al. 1994. The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Nat Acad Sci USA 91:10898-10902.
    • (1994) Proc Nat Acad Sci USA , vol.91 , pp. 10898-10902
    • Kordower, J.H.1    Winn, S.R.2    Liu, S.R.3    Mufson, E.J.4    Sladek, J.R.5
  • 39
    • 0023067115 scopus 로고
    • Nerve growth factor treatment after brain injury prevents neuronal death
    • Kromer LF. 1987. Nerve growth factor treatment after brain injury prevents neuronal death. Science 235:214-216.
    • (1987) Science , vol.235 , pp. 214-216
    • Kromer, L.F.1
  • 41
    • 39749109431 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism ofm intravascular neural stem cell transplantation in haemorrhagic stroke
    • Lee ST, Chu K, Jung KH, Kim SJ, Kim DH, et al. 2008. Anti-inflammatory mechanism ofm intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131:616-629.
    • (2008) Brain , vol.131 , pp. 616-629
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3    Kim, S.J.4    Kim, D.H.5
  • 42
    • 34247636618 scopus 로고    scopus 로고
    • Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model
    • Lee HJ, Kim KS, Kim EJ, Choi HB, Lee KH. 2007. Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 25:1204-1212.
    • (2007) Stem Cells , vol.25 , pp. 1204-1212
    • Lee, H.J.1    Kim, K.S.2    Kim, E.J.3    Choi, H.B.4    Lee, K.H.5
  • 43
    • 34447274187 scopus 로고    scopus 로고
    • Human neural stem cells overexpressing VEGF provides neuroprotection, angiogenesis and functional recovery in mouse stroke model
    • Lee HJ, Kim KS, Kim EJ, Park IH, Kim SU. 2007. Human neural stem cells overexpressing VEGF provides neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 1:e156.
    • (2007) PLoS One , vol.1 , pp. e156
    • Lee, H.J.1    Kim, K.S.2    Kim, E.J.3    Park, I.H.4    Kim, S.U.5
  • 44
    • 78649413561 scopus 로고    scopus 로고
    • Human neural stem cells genetically modified to overexpress BDNF promote functional recovery and neuroprotection in mouse stroke model
    • Lee HJ, Lim IJ, Lee MC, Kim SU. 2010. Human neural stem cells genetically modified to overexpress BDNF promote functional recovery and neuroprotection in mouse stroke model. J Neurosci Res 88:3282-3294.
    • (2010) J Neurosci Res , vol.88 , pp. 3282-3294
    • Lee, H.J.1    Lim, I.J.2    Lee, M.C.3    Kim, S.U.4
  • 45
    • 84864795944 scopus 로고    scopus 로고
    • Human neural stem cells genetically modified to express human nerve growth factor (hNGF) gene restore cognition in the mouse with ibotenic acidinduced cognitive dysfunction
    • Lee HJ, Lim IJ, Park SW, Kim YB, Ko Y, Kim SU. 2012. Human neural stem cells genetically modified to express human nerve growth factor (hNGF) gene restore cognition in the mouse with ibotenic acidinduced cognitive dysfunction. Cell Transplant 212487-2496.
    • (2012) Cell Transplant , vol.212 , pp. 487-2496
    • Lee, H.J.1    Lim, I.J.2    Park, S.W.3    Kim, Y.B.4    Ko, Y.5    Kim, S.U.6
  • 46
    • 70249116026 scopus 로고    scopus 로고
    • Human neural stem cells overexpressing glial cell line derived neurotrophic factor (GDNF) promote functional recovery and neuroprotection in experimental cerebral hemorrhage
    • Lee HJ, Park IH, Kim HJ, Kim SU. 2009. Human neural stem cells overexpressing glial cell line derived neurotrophic factor (GDNF) promote functional recovery and neuroprotection in experimental cerebral hemorrhage. Gene Ther 16:1066-1076.
    • (2009) Gene Ther , vol.16 , pp. 1066-1076
    • Lee, H.J.1    Park, I.H.2    Kim, H.J.3    Kim, S.U.4
  • 49
    • 84871706599 scopus 로고    scopus 로고
    • Transcription factors expressed in embryonic and adult olfactory bulb neural stem cells reveal distinct proliferation, differentiation and epigenetic control
    • Marei HE, Ahmed AE. 2013. Transcription factors expressed in embryonic and adult olfactory bulb neural stem cells reveal distinct proliferation, differentiation and epigenetic control. Genomics 101:12-19.
    • (2013) Genomics , vol.101 , pp. 12-19
    • Marei, H.E.1    Ahmed, A.E.2
  • 50
    • 84859231145 scopus 로고    scopus 로고
    • Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control
    • Marei HES, Ahmed A-E, Michetti F, Pescatori M, Pallini R, et al. 2012. Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control. PLoS One 7:e33542.
    • (2012) PLoS One , vol.7 , pp. e33542
    • Marei, H.E.S.1    Ahmed, A.-E.2    Michetti, F.3    Pescatori, M.4    Pallini, R.5
  • 51
    • 82855172151 scopus 로고    scopus 로고
    • Gene expression profilingof embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra
    • Marei HES, Althani A, Afifi N, Michetti F, Pescatori M, et al. 2011. Gene expression profilingof embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. PLoS ONE 6:e28420.
    • (2011) PLoS ONE , vol.6 , pp. e28420
    • Marei, H.E.S.1    Althani, A.2    Afifi, N.3    Michetti, F.4    Pescatori, M.5
  • 52
    • 84893198150 scopus 로고    scopus 로고
    • Over-expression of hNGF in adult human olfactory bulb neural stem cells promotes cell growth and oligodendrocytic differentiation
    • Marei HES, Althani A, Afifi N, Abd-Elmaksoud A, Bernardini C, et al. 2013. Over-expression of hNGF in adult human olfactory bulb neural stem cells promotes cell growth and oligodendrocytic differentiation. PLoS One 8:e82206.
    • (2013) PLoS One , vol.8 , pp. e82206
    • Marei, H.E.S.1    Althani, A.2    Afifi, N.3    Abd-Elmaksoud, A.4    Bernardini, C.5
  • 53
    • 0030838238 scopus 로고    scopus 로고
    • Immortalized neural progenitor cells for CNS gene transfer and repair
    • Martinez-Serrano A, Bjorklund A. 1997. Immortalized neural progenitor cells for CNS gene transfer and repair. Trends Neurosci 20:530-538.
    • (1997) Trends Neurosci , vol.20 , pp. 530-538
    • Martinez-Serrano, A.1    Bjorklund, A.2
  • 54
    • 0029080919 scopus 로고
    • Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain
    • Martinez-Serrano A, Fischer W, Bjorklund A. 1995. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain. Neuron 15:473-484.
    • (1995) Neuron , vol.15 , pp. 473-484
    • Martinez-Serrano, A.1    Fischer, W.2    Bjorklund, A.3
  • 55
    • 0035453310 scopus 로고    scopus 로고
    • Human neural stem and progenitor cells: In vitro and in vivo properties, and potential for gene therapy and cell replacement in the CNS
    • Martínez-Serrano A, Rubio FJ, Navarro B, Bueno C, Villa A. 2001. Human neural stem and progenitor cells: In vitro and in vivo properties, and potential for gene therapy and cell replacement in the CNS. Curr Gene Ther 1:279-299.
    • (2001) Curr Gene Ther , vol.1 , pp. 279-299
    • Martínez-Serrano, A.1    Rubio, F.J.2    Navarro, B.3    Bueno, C.4    Villa, A.5
  • 56
    • 0035741573 scopus 로고    scopus 로고
    • Stem cells as therapeutics for neurodegenerative disorders?
    • Mattson MP. 2001. Stem cells as therapeutics for neurodegenerative disorders? Expert Rev, Neurotherapeu 1:267-273.
    • (2001) Expert Rev, Neurotherapeu , vol.1 , pp. 267-273
    • Mattson, M.P.1
  • 59
    • 21144432093 scopus 로고    scopus 로고
    • Multipotent stem cells from adult olfactory mucosa
    • Murrell W, Feron F. 2005. Multipotent stem cells from adult olfactory mucosa. Dev Dyn 233496-515.
    • (2005) Dev Dyn , vol.233 , pp. 496-515
    • Murrell, W.1    Feron, F.2
  • 60
    • 35748978820 scopus 로고    scopus 로고
    • Recent development in cholinesterase inhibitors for Alzheimer's disease treatment
    • Musial A, Bajda M, Malawska B. 2007. Recent development in cholinesterase inhibitors for Alzheimer's disease treatment. Curr Med Chem 14:2654-2679.
    • (2007) Curr Med Chem , vol.14 , pp. 2654-2679
    • Musial, A.1    Bajda, M.2    Malawska, B.3
  • 61
    • 0037395114 scopus 로고    scopus 로고
    • Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
    • Nunes MC, Roy NS, Keyoung HM, et al. 2003. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9:439-447.
    • (2003) Nat Med , vol.9 , pp. 439-447
    • Nunes, M.C.1    Roy, N.S.2    Keyoung, H.M.3
  • 62
    • 0033854826 scopus 로고    scopus 로고
    • Isolation and characterization of neural stem cells from the adult human olfactory bulb
    • Pagano F, Impagnatiello F, Girelli M, Cova L,Grioni E, et al. 2000. Isolation and characterization of neural stem cells from the adult human olfactory bulb. Stem Cells 18:295-300.
    • (2000) Stem Cells , vol.18 , pp. 295-300
    • Pagano, F.1    Impagnatiello, F.2    Girelli, M.3    Cova, L.4    Grioni, E.5
  • 64
    • 84862781166 scopus 로고    scopus 로고
    • Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction
    • Park D, Lee HJ, Joo SS, Bae DK, et al. 2012. Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction. Exp Neurol 234521-526.
    • (2012) Exp Neurol , vol.234 , pp. 521-526
    • Park, D.1    Lee, H.J.2    Joo, S.S.3    Bae, D.K.4
  • 65
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells from the adult mammalian central nervous system
    • Reynolds BA, Weiss S. 1992. Generation of neurons and astrocytes from isolated cells from the adult mammalian central nervous system. Science 255:1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 66
    • 0029983762 scopus 로고    scopus 로고
    • Clonal and population analyses demonstrate that an EGF responsive mammalian embryonic CNS precursor is a stem cell
    • Reynolds BA, Weiss S. 1996. Clonal and population analyses demonstrate that an EGF responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 175:1-13.
    • (1996) Dev Biol , vol.175 , pp. 1-13
    • Reynolds, B.A.1    Weiss, S.2
  • 68
    • 0024263047 scopus 로고
    • Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression
    • Rosenberg MB, Friedmann T, Robertson RC, Tuszynski M, Wolff JA, et al. 1988. Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression. Science 242:1575-1578.
    • (1988) Science , vol.242 , pp. 1575-1578
    • Rosenberg, M.B.1    Friedmann, T.2    Robertson, R.C.3    Tuszynski, M.4    Wolff, J.A.5
  • 69
    • 0031006419 scopus 로고    scopus 로고
    • Bipotent progenitor cell lines from the human CNS
    • Sah DW, Ray J, Gage F. 1997. Bipotent progenitor cell lines from the human CNS. Nat Biotech 15:574-580.
    • (1997) Nat Biotech , vol.15 , pp. 574-580
    • Sah, D.W.1    Ray, J.2    Gage, F.3
  • 71
    • 0025790094 scopus 로고
    • Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids
    • Schumacher JM, Short MP, Hyman BT, Breakefield XO, Isacson O. 1991. Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Neuroscience 45:561-570.
    • (1991) Neuroscience , vol.45 , pp. 561-570
    • Schumacher, J.M.1    Short, M.P.2    Hyman, B.T.3    Breakefield, X.O.4    Isacson, O.5
  • 72
    • 0034548865 scopus 로고    scopus 로고
    • Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus J
    • Shihabuddin LS, Horner PJ, Ray J, Gage FH. 2000. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus J. J Neurosci 20:8727-8735.
    • (2000) J Neurosci , vol.20 , pp. 8727-8735
    • Shihabuddin, L.S.1    Horner, P.J.2    Ray, J.3    Gage, F.H.4
  • 73
    • 34547095240 scopus 로고    scopus 로고
    • Spontaneous transformation of human adult non-tumorigenic stem cells to cancer stem cells is driven by genomic instability in a human adult model of glioblastoma
    • Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR. 2007. Spontaneous transformation of human adult non-tumorigenic stem cells to cancer stem cells is driven by genomic instability in a human adult model of glioblastoma. Stem Cells 25:1478-1489.
    • (2007) Stem Cells , vol.25 , pp. 1478-1489
    • Shiras, A.1    Chettiar, S.T.2    Shepal, V.3    Rajendran, G.4    Prasad, G.R.5
  • 74
    • 0028032236 scopus 로고
    • Grafting immortalized neurons to the CNS
    • Snyder Y. 1994. Grafting immortalized neurons to the CNS. Curr OpinNeurobiol 4:742-751.
    • (1994) Curr OpinNeurobiol , vol.4 , pp. 742-751
    • Snyder, Y.1
  • 75
    • 58249088720 scopus 로고    scopus 로고
    • Long-term functional restoration by neural progenitor cell transplantation in mouse model of cognitive dysfunction: Cotransplantation with olfactory ensheathing cells for neurotrophic factor support
    • Srivastava N, Seth K, Khanna VK, Ansari RW, Agrawal AK. 2009. Long-term functional restoration by neural progenitor cell transplantation in mouse model of cognitive dysfunction: Cotransplantation with olfactory ensheathing cells for neurotrophic factor support. Int J Dev Neurosci 27:103-110.
    • (2009) Int J Dev Neurosci , vol.27 , pp. 103-110
    • Srivastava, N.1    Seth, K.2    Khanna, V.K.3    Ansari, R.W.4    Agrawal, A.K.5
  • 76
    • 84895804116 scopus 로고    scopus 로고
    • Aging-and injury-related differential apoptotic response in the dentate gyrus of the hippocampus inrats following brain trauma
    • Sun D, McGinn M, Hankins JE, Mays KM, Rolfe A, Colello R J. 2013. Aging-and injury-related differential apoptotic response in the dentate gyrus of the hippocampus inrats following brain trauma. Front Aging Neurosci 5:95.
    • (2013) Front Aging Neurosci , vol.5 , pp. 95
    • Sun, D.1    McGinn, M.2    Hankins, J.E.3    Mays, K.M.4    Rolfe, A.5    Colello, R.J.6
  • 77
    • 0033178867 scopus 로고    scopus 로고
    • New prospects for human stem-cell therapy in the nervous system
    • Svendsen CN, Smith AG. 1999. New prospects for human stem-cell therapy in the nervous system. Trends Neurosci 22:357-364.
    • (1999) Trends Neurosci , vol.22 , pp. 357-364
    • Svendsen, C.N.1    Smith, A.G.2
  • 78
    • 0042433479 scopus 로고    scopus 로고
    • The cholinergic hypothesis of age and Alzheimer's diseaserelated cognitive deficits: Recent challenges and their implications for novel drug development
    • Terry AV, Buccafusco JJ. 2003. The cholinergic hypothesis of age and Alzheimer's diseaserelated cognitive deficits: Recent challenges and their implications for novel drug development. J Pharmacol Exp Ther 306:821-217.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 217-821
    • Terry, A.V.1    Buccafusco, J.J.2
  • 79
    • 0018881876 scopus 로고
    • Dementia of the Alzheimer's type
    • Terry RD, Davies P. 1980. Dementia of the Alzheimer's type. Annu Rev Neurosci 3:77-95.
    • (1980) Annu Rev Neurosci , vol.3 , pp. 77-95
    • Terry, R.D.1    Davies, P.2
  • 80
    • 0030661759 scopus 로고    scopus 로고
    • Inflammation promotes survival and migration of the CG4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats
    • Tourbah A, Linnington C, Bachelin C, Avellana-Adalid V, Wekerle H, Baron-Van Evercooren A. 1997. Inflammation promotes survival and migration of the CG4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats. J Neurosci Res 50:853-861.
    • (1997) J Neurosci Res , vol.50 , pp. 853-861
    • Tourbah, A.1    Linnington, C.2    Bachelin, C.3    Avellana-Adalid, V.4    Wekerle, H.5    Baron-Van Evercooren, A.6
  • 81
    • 0037654372 scopus 로고    scopus 로고
    • Gene therapy for neurodegenerative disorders
    • Tuszynski MH. 2002. Gene therapy for neurodegenerative disorders. Lancet Neurol 1:51-57.
    • (2002) Lancet Neurol , vol.1 , pp. 51-57
    • Tuszynski, M.H.1
  • 82
    • 0025513602 scopus 로고
    • Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration
    • Tuszynski MH, Amaral DG, Gage FH. 1990. Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci 10:3604-3614.
    • (1990) J Neurosci , vol.10 , pp. 3604-3614
    • Tuszynski, M.H.1    Amaral, D.G.2    Gage, F.H.3
  • 83
    • 0026008812 scopus 로고
    • Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain
    • Tuszynski MH, Gage FH. 1991. Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann Neurol 30:625-636.
    • (1991) Ann Neurol , vol.30 , pp. 625-636
    • Tuszynski, M.H.1    Gage, F.H.2
  • 84
    • 0030002982 scopus 로고    scopus 로고
    • Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
    • Tuszynski MH, Roberts J, Senut MC, Gage FH. 1996. Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther 3:305-314.
    • (1996) Gene Ther , vol.3 , pp. 305-314
    • Tuszynski, M.H.1    Roberts, J.2    Senut, M.C.3    Gage, F.H.4
  • 85
    • 21044458854 scopus 로고    scopus 로고
    • A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer's disease
    • Tuszynski MH, Thal L, Pay M, Salmon DP, Bakay R, et al. 2005. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer's disease. Nat Med 11:551-555.
    • (2005) Nat Med , vol.11 , pp. 551-555
    • Tuszynski, M.H.1    Thal, L.2    Pay, M.3    Salmon, D.P.4    Bakay, R.5
  • 86
    • 0033044937 scopus 로고    scopus 로고
    • Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo
    • Vescovi AL, Snyder EY. 1999. Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo. Brain Pathol 569-598.
    • (1999) Brain Pathol , pp. 569-598
    • Vescovi, A.L.1    Snyder, E.Y.2
  • 87
    • 0036098417 scopus 로고    scopus 로고
    • Genetic perpetuation of in vitro expanded human neural stem cells (HNSCs): cellular properties and therapeutic potential
    • Villa A, Navarro B, Martínez-Serrano A. 2002. Genetic perpetuation of in vitro expanded human neural stem cells (HNSCs): cellular properties and therapeutic potential. Brain Res Bull 57:789-794.
    • (2002) Brain Res Bull , vol.57 , pp. 789-794
    • Villa, A.1    Navarro, B.2    Martínez-Serrano, A.3
  • 89
    • 0034008662 scopus 로고    scopus 로고
    • Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS
    • Villa A, Snyder Y, Vescovi A, Martinez A. 2000. Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol 161:67-84.
    • (2000) Exp Neurol , vol.161 , pp. 67-84
    • Villa, A.1    Snyder, Y.2    Vescovi, A.3    Martinez, A.4
  • 90
    • 0141676654 scopus 로고    scopus 로고
    • Stem cells from the adult human brain develop into functional neurons in culture
    • Westerlund U, Moe MC, Varghese M, et al. 2003. Stem cells from the adult human brain develop into functional neurons in culture. Exp Cell Res 289:378-383.
    • (2003) Exp Cell Res , vol.289 , pp. 378-383
    • Westerlund, U.1    Moe, M.C.2    Varghese, M.3
  • 91
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse PJ, Price DL, Struble RG, Clarkk AW. 1982. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215:1237-1239.
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clarkk, A.W.4
  • 92
    • 0030079438 scopus 로고    scopus 로고
    • Physiological relevance and functional potential of central nervous system-derived cell lines
    • Whittemore R, Snyder Y. 1996. Physiological relevance and functional potential of central nervous system-derived cell lines. Mol Neurobiol 12:13-38.
    • (1996) Mol Neurobiol , vol.12 , pp. 13-38
    • Whittemore, R.1    Snyder, Y.2
  • 93
    • 0037188447 scopus 로고    scopus 로고
    • Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system
    • Widy-Tyszkiewicz E, Piechal A, Gajkowska B, Smialek M. 2002. Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system. Toxicol Lett 131:203-214.
    • (2002) Toxicol Lett , vol.131 , pp. 203-214
    • Widy-Tyszkiewicz, E.1    Piechal, A.2    Gajkowska, B.3    Smialek, M.4
  • 94
    • 0025816941 scopus 로고
    • Hypophagia is induced by intracerebroventricular administration of nerve growth factor
    • Williams LR. 1991. Hypophagia is induced by intracerebroventricular administration of nerve growth factor. Exp Neurol 113:31-37.
    • (1991) Exp Neurol , vol.113 , pp. 31-37
    • Williams, L.R.1
  • 95
    • 0001460060 scopus 로고    scopus 로고
    • Reversible induction of Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites in vivo after continuous intracerebroventricular administration of nerve growth factor
    • Winkler J, Ramirez GA, Kuhn HG, Peterson DA, Day-Lollini PA. 1996. Reversible induction of Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites in vivo after continuous intracerebroventricular administration of nerve growth factor. Ann. Neurol 40:128-139.
    • (1996) Ann Neurol , vol.40 , pp. 128-139
    • Winkler, J.1    Ramirez, G.A.2    Kuhn, H.G.3    Peterson, D.A.4    Day-Lollini, P.A.5
  • 96
    • 0028793322 scopus 로고
    • Effects of nerve growth factor treatment on rats with lesions of the nucleus basalis magnocellularis produced by ibotenic acid, quisqualic acid, and AMPA
    • Winkler J, Thal J. 1995. Effects of nerve growth factor treatment on rats with lesions of the nucleus basalis magnocellularis produced by ibotenic acid, quisqualic acid, and AMPA. Exp Neurol 136234-250.
    • (1995) Exp Neurol , vol.136 , pp. 234-250
    • Winkler, J.1    Thal, J.2
  • 97
    • 45849098696 scopus 로고    scopus 로고
    • BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix
    • Xuan AG, Long DH, Gu HG, Yang DD, Hong LP, Leng SL. 2008. BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix. Neurosci Lett 440:331-335.
    • (2008) Neurosci Lett , vol.440 , pp. 331-335
    • Xuan, A.G.1    Long, D.H.2    Gu, H.G.3    Yang, D.D.4    Hong, L.P.5    Leng, S.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.