Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain

Nature Medicine

Volumn 9, Issue 4, 2003, Pages 439-447

  Nunes, Marta C ^a   Roy, Neeta Singh ^a   Keyoung, H Michael ^a   Goodman, Robert R ^b   McKhann II, Guy ^b   Jiang, Li ^c   Kang, Jian ^c   Nedergaard, Maiken ^c   Goldman, Steven A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Columbia Univ Coll of Phys/Surgs ^*  (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ASSAY; CELL ISOLATION; CLINICAL ARTICLE; FEMALE; FETUS; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOSIS; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL; WHITE MATTER; XENOGRAFT;

ADOLESCENT; ADULT; AGED; BRAIN; BRAIN TISSUE TRANSPLANTATION; CELL DIFFERENTIATION; CELL DIVISION; CELL SEPARATION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; HUMANS; INFANT; MALE; MIDDLE AGED; NEUROGLIA; NEURONS; STEM CELL TRANSPLANTATION; STEM CELLS;

ANIMALIA;

EID: 0037395114     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm837     Document Type: Article

References (41)

1. Scolding, N. et al. Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis [see comments]. Brain 121, 2221-2228 (1998).
2. Roy, N.S. et al. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J. Neurosci. 19, 9986-9995 (1999).
3. Gravel, M., DiPolo, A., Valera, P. & Braun, P. Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice. J. Neurosci. Res. 53, 393-404 (1998).
4. Kondo, T. & Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754-1757 (2000).
5. Palmer, T.D., Markakis, E.A., Willhoite, A.R., Safar, F. & Gage, F.H. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J. Neurosci. 19, 8487-8497 (1999).
6. Reynolds, B.A. & Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707-1710 (1992).
7. Vescovi, A.L., Reynolds, B.A., Fraser, D.D. & Weiss, S. bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells. Neuron 11, 951-966 (1993).
8. Morshead, C.M. et al. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron 13, 1071-1082 (1994).
9. Vescovi, A. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human stem cells lines by epigenetic stimulation. Exp. Neurol. 156, 71-83 (1999).
10. Svendsen, C., Caldwell, M. & Ostenfeld, T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol. 9, 499-513 (1999).
11. Carpenter, M. et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158, 265-278 (1999).
12. Han, J. et al. Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum. Gene Ther. 10, 1867-1873 (1999).
13. Zufferey, R., Donello, I., Trono, D. & Hope, H. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73, 2886-2892 (1999).
14. Windrem, M. et al. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated regions of the rat brain. J. Neurosci. Res. 69, 966-975 (2002).
15. Kang, I., Jiang, L., Goldman, S.A. & Nedergaard, M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nat. Neurosci. 1, 683-692 (1998).
16. + currents in acutely isolated hippocampal astrocytes. J. Neurosci. 12, 1781-1788 (1992).
17. Barres, B.A. et al. A crucial role for neurotrophin-3 in oligodendrocyte development. Nature 367, 371-375 (1994).
18. Raff, M.C., Lillien, L.E., Richardson, W.D., Burne, J.F. & Noble, M.D. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature 333, 562-565 (1988).
19. Vicario-Abejon, C., Johe, K.K., Hazel, T.G., Collazo, D. & McKay, R.D. Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons. Neuron 15, 105-114 (1995).
20. Johe, K.K., Hazel, T.G., Muller, T., Dugich-Djordjevic, M.M. & McKay, R.D. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10, 3129-3140 (1996).
21. Keyoung, H.M. et al. Specific identification, selection and extraction of neural stem cells from the fetal human brain. Nat. Biotechnol. 19, 843-850 (2001).
22. Yashima, K. et al. Expression of the RNA component of telomerase during human development and differentiation. Cell Growth Differ. 9, 805-813 (1998).
23. Ostenfeld, T. et al. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp. Neurol. 164, 215-226 (2000).
24. Kim, N. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
25. Gleeson, J., Lin, P., Flanagan, L. & Walsh, C. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23, 257-271 (1999).
26. Doetsch, F., Caille, I., Lim, D., Garcia-Verdugo, J. & Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716 (1999).
27. Alvarez-Buylla, A. & Garcia-Verdugo, J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629-634 (2002).
28. Kukekov, V., Laywell, E., Thomas, L. & Steindler, D. A nestin-negative precursor cell from the adult mouse brain gives rise to neurons and glia. Glia 21, 399-407 (1997).
29. Levine, J.M., Reynolds, R. & Fawcett, J.W. The oligodendrocyte precursor cell in health and disease. Trends Neurosci. 24, 39-47 (2001).
30. + cycling progenitors in the adult forebrain white matter respond differentially to PDGF-AA, FGF-2, and IGF-1. Molec. Cell. Neurosci. 20, 30-42 (2002).
31. Jiang, Y. et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41 -49 (2002).
32. Capela, A. & Temple, S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 35, 865-875 (2002).
33. Roy, N.S. et al. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat. Med. 6, 271-277 (2000).
34. Roy, N.S. et al. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. J. Neurosci. Res. 59, 321-331 (2000).
35. Wang, S. et al. Isolation of neuronal precursors by sorting embryonic forebrain transfected with GFP regulated by the T α 1 tubulin promoter. Nat. Biotechnol. 16, 196-201 (1998).
36. Brustle, O. et al. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nat. Biotechnol. 16, 1040-1044 (1998).
37. Benraiss, A., Chmielnicki, E., Roh, D. & Goldman, S.A. Adenoviral BDNF induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J. Neurosci. 21, 6718-6731 (2001).
38. Kirschenbaum, B. et al. In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb. Cortex 4, 576-589 (1994).
39. Pincus, D.W. et al. FGF2/BDNF-associated maturation of new neurons generated from adult human subependymal cells. Ann. Neurol. 43, 576-585 (1998).
40. Marusich, M., Furneaux, H., Henion, P. & Weston, J. Hu neuronal proteins are expressed in proliferating neurogenic cells. J. Neurobiol. 25, 143-155 (1994).
41. Barami, K., Iversen, K., Furneaux, H. & Goldman, S.A. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J. Neurobiol. 28, 82-101 (1995).