Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease

Brain Research

Volumn 805, Issue 1-2, 1998, Pages 267-269

  Bobinski, Maciej ^a   De Leon, Mony J ^b,c   Tarnawski, Michal ^a   Wegiel, Jerzy ^a   Bobinski, Margaret ^a   Reisberg, Barry ^b   Miller, Douglas C ^b   Wisniewski, Henryk M ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Alzheimer disease; Atrophy; Clinicopathological correlations; Hippocampus; Neuronal loss; Stereology

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; CELL LOSS; CELL VOLUME; CLINICAL ARTICLE; DISEASE DURATION; DISEASE SEVERITY; ENTORHINAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MULTIPLE REGRESSION; PRIORITY JOURNAL; STEREOLOGY; SUBICULUM;

ALZHEIMER DISEASE; ATROPHY; HIPPOCAMPUS; HUMANS; NEURONS; PROGNOSIS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 0032517186     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00759-8     Document Type: Article

References (15)

1. M.J. Ball, Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia, Acta Neuropathol. (Berlin) 37 (1977) 111-118.
2. M.J. Ball, Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of ageing and demented patients, Interdiscipl. Topics Geront. 25 (1988) 16-37.
3. M.J. Bobinski, J. Wegiel, M. Tarnawski, M. Bobinski, B. Reisberg, M.J. De Leon, D.C. Miller, H.M. Wisniewski, Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease, J. Neuropathol. Exp. Neurol. 56 (1997) 414-420.
4. M.J. Bobinski, J. Wegiel, H.M. Wisniewski, M. Tarnawski, M. Bobinski, B. Reisberg, M.J. De Leon, D.C. Miller, Neurofibrillary pathology - correlation with hippocampal formation atrophy in Alzheimer disease, Neurobiol. Aging 17 (1996) 909-919.
5. H. Braak, E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol. 82 (1991) 239-259.
6. P.D. Coleman, D.G. Flood, Neuron numbers and dendritic extent in normal aging and Alzheimer's disease, Neurobiol. Aging 8 (1987) 521-545.
7. A. Convit, M.J. De Leon, C. Tarshish, S. De Santi, W. Tsui, H. Rusinek, A.E. George, Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease, Neurobiol. Aging 18 (1997) in press.
8. D.C. Davies, N. Horwood, S.L. Isaacs, D.M.A. Mann, The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation, Acta Neuropathol. 83 (1992) 510-517.
9. T. Gomez-Isla, J.L. Price, D.W. McKeel Jr., J.C. Morris, J.H. Growdon, B.T. Hyman, Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease, J. Neurosci. 16 (1996) 4491-4500.
10. B.T. Hyman, G.W. Van Hoesen, A.R. Damasio, C.L. Barnes, Alzheimer's disease: cell-specific pathology isolates the hippocampal formation, Science 225 (1984) 1168-1170.
11. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D.L. Price, E.M. Stadlan, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology 34 (1984) 939-944.
12. S.S. Mirra, M. Noel Hart, R.D. Terry, Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists, Arch. Pathol. Lab. Med. 117 (1993) 132-144.
13. B. Reisberg, Functional assessment staging (FAST), Psychopharmacol. Bull. 24 (1988) 653-659.
14. M.J. West, P.D. Coleman, D.G. Flood, J.C. Troncoso, Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease, Lancet 344 (1994) 769-772.
15. M.J. West, H.J.G. Gundersen, Unbiased stereological estimation of the number of neurons in the human hippocampus, J. Comp. Neurol. 296 (1990) 1-22.