Global gene and cell replacement strategies via stem cells

Gene Therapy

Volumn 9, Issue 10, 2002, Pages 613-624

  Park, K I ^a,b   Ourednik, J ^a   Ourednik, V ^a   Taylor, R M ^c   Aboody, K S ^a,d   Auguste, K I ^a   Lachyankar, M B ^a   Redmond, D E ^e   Snyder, E Y ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Yonsei University College of Medicine   (South Korea)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Layton Biosciences   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

Development; Gene therapy; Mental retardation; Neural transplantation; Neurodegeneration; Neuroregeneration and repair

Indexed keywords

CYTOSINE DEAMINASE; DRUG VEHICLE; INTRINSIC FACTOR; NEUROTROPHIN 3;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN TUMOR; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE REPLACEMENT THERAPY; GENE TRANSFER; HUMAN; MOUSE; NERVE CELL; NERVE REGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

ADULT; AMYLOIDOSIS; ANIMALS; BRAIN ISCHEMIA; BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM; GENE THERAPY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MENTAL RETARDATION; MODELS, NEUROLOGICAL; NERVE DEGENERATION; NERVE REGENERATION; TRAUMA, NERVOUS SYSTEM;

ANIMALIA;

EID: 85047698195     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301721     Document Type: Review

References (67)

1. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesion. I. Evidence for anatomical reconstruction of the nigrostriatal pathway
2. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery
3. Neuropathological evidence of graft survival and striatal reinervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease
4. Transplantation of embryonic dopamine neurons for severe Parkinson's disease
5. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain
6. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes
7. Himeric brains generated by intarventricular transplantation of fetal human brain cells into embryonic rats
8. Global' cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain
9. Segregation of human neural stem cells in the developing primate forebrain
10. Transplantation of neural progenitors and stem-like cells as a strategy for gene therapy and repair of neurodegenerative diseases
11. Stem cells in the central nervous system
12. Neural precursor cells: Applications for the study and repair of the central nervous system
13. Mammalian neural stem cells
14. Neural stem cells
15. Establishment and properties of neural stem cell clones: Plasticity in vitro and in vivo
16. Somatic gene transfer of NGF to the aged brain: Behavioral and morphologic amelioration
17. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
18. Neural stem cells secrete BDNF and GDNF, and promote axonal growth after spinal cord injury
19. Functional Neural Transplantation
20. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
21. Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex
22. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
23. Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor
24. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
25. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor
26. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
27. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
28. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain
29. In vitro differentiation of transplantable neural precursors from human embryonic stem cells
30. Neural progenitors from human embryonic stem cells: Derivation, expansion, and characterization of their developmental potential in vitro and in vivo
31. Hypoxic-ischemic (HI) injury may direct the proliferation, migration, and differentiation of endogenous neural progenitors
32. Induction of neurogenesis in the neocortex of adult mice
33. Is there a neural stem cell in the mammalian forebrain?
34. Neural stem cell in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells
35. A self-renewing multipotential stem cell in embryonic rat cerebral cortex
36. Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus
37. Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex
38. Transplantation of neural progenitor and stem-like cells: Developmental insights may suggest new therapies for spinal cord and other CNS dysfunction
39. Neural stem cells display extensive tropism for pathology in the adult brain: Evidence from intracranial gliomas
40. Massive regeneration of substantia nigra neurons in aged parkinsonian mice after transplantation of neural stem cells overexpressing L1
41. Expression of human β-hexosaminidase α-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells
42. Neural stem cells: A versatile tool for cell replacement and gene therapy in the CNS
43. Inborn errors of mucopolysaccharide metabolism
44. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
45. Long distance neuronal migration in the adult mammalian brain
46. Neural stem-like cells: Developmental lessons with therapeutic potential
47. Direct isolation of human central nervous system stem cells
48. Neural stem cells as engraftable packaging lines optimize viral vector-mediated gene delivery to the CNS: Evidence from studying retroviral envrelated neurodegeneration
49. BDNF gene transfer to the mammalian brain using CNS-derived neural precursors
50. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats
51. Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus
52. CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: Complete rescue of axotomized cholinergic neurons after transplantation into the septum
53. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain
54. Neural-targeted gene therapy for rodent and primate hemiparkinsonism
55. Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses
56. Neural transplantation of cells expressing the anti-apoptotic gene bc1-2
57. Neuroprotection through delivery of GDNF by neural stem cells in a mouse model of Parkinson's disease
58. Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action
59. Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats
60. Migration of neural stem cells to Alzheimer-like lesions in an animal model of AD
61. Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS
62. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
63. FGF2/BDNF-associated maturation of new neurons generated from adult human subependymal cells
64. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation
65. Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain
66. In vitro-genereated neural precursors participate in mammalian brain development