Development of neuronal networks from single stem cells harvested from the adult human brain

Neurosurgery

Volumn 56, Issue 6, 2005, Pages 1182-1188

  Moe, Morten C ^a   Westerlund, Ulf ^a   Varghese, Mercy ^b   Berg Johnsen, Jon ^b   Svensson, Mikael ^a   Langmoen, Iver A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Action potentials; Differentiation; Human; Neural; Stem cells; Synaptic connections

Indexed keywords

CELL MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOGRAFT; BRAIN BIOPSY; BRAIN DEVELOPMENT; BRAIN VENTRICLE; CASE REPORT; CELL COMMUNICATION; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM DISEASE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISSOCIATION; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NERVE CELL NETWORK; PATCH CLAMP; PRIORITY JOURNAL; SCHOOL CHILD; STEM CELL; SYNAPTIC MEMBRANE;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ADOLESCENT; ADULT; AGED; BRAIN; CALCIUM; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CHILD; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, RADIATION; DROSOPHILA PROTEINS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE POTENTIALS; MIDDLE AGED; NERVE NET; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHLORIDE; RECEPTORS, GLUTAMATE; STEM CELLS; SYNAPTOPHYSIN; TIME FACTORS; TUBULIN; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 20044368469     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000159881.09663.6D     Document Type: Article

References (34)

1. Arsenijevic Y, Villemure JG, Brunet JF, Bloch JJ, Deglon N, Kostic C, Zurn A, Aebischer P: Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Exp Neurol 170:48-62, 2001.
2. Berg-Johnsen J, Haugstad TS, Langmoen IA: Glutamate in the human brain: Possible roles in synaptic transmission and ischemia. Prog Brain Res 116: 287-302, 1998.
3. Bjorklund A, Lindvall O: Cell replacement therapies for central nervous system disorders. Nat Neurosci 3:537-544, 2000.
4. Bordey A, Sontheimer H: Ion channel expression by astrocytes in situ: Comparison of different CNS regions. Glia 30:27-38, 2000.
5. Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH: Neurogenesis in the adult human hippocampus. Nat Med 4:1313-1317, 1998.
6. Fonnum F: Glutamate: A neurotransmitter in mammalian brain. J Neurochem 42:1-11, 1984.
7. Gage FH: Mammalian neural stem cells. Science 287:1433-1438, 2000.
8. Gould E, Gross CG: Neurogenesis in adult mammals: Some progress and problems. J Neurosci 22:619-623, 2002.
9. 2+ changes in hippocampal CA1 neurons during energy deprivation. Brain Res 785:58-65, 1998.
10. Gross CG: Neurogenesis in the adult brain: Death of a dogma. Nat Rev Neurosci 1:67-73, 2000.
11. Hablitz JJ, Langmoen IA: Excitation of hippocampal pyramidal cells by glutamate in the guinea-pig and rat. J Physiol 325:317-331, 1982.
12. Hales TG, Tyndale RF: Few cell lines with GABAA mRNAs have functional receptors. J Neurosci 14:5429-5436, 1994.
13. Isaac JT: Postsynaptic silent synapses: Evidence and mechanisms. Neuropharmacology 45:450-460, 2003.
14. Jahn R, Schiebler W, Ouimet C, Greengard P: A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 82:4137-4141, 1985.
15. Johansson CB, Svensson M, Wallstedt L, Janson AM, Frisen J: Neural stem cells in the adult human brain. Exp Cell Res 253:733-736, 1999.
16. Kirschenbaum B, Nedergaard M, Preuss A, Barami K, Fraser RA, Goldman SA: In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain. Cereb Cortex 4:576-589, 1994.
17. Kukekov VG, Laywell ED, Suslov O, Davies K, Scheffler B, Thomas LB, O'Brien TF, Kusakabe M, Steindler DA: Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol 156:333-344, 1999.
18. Langmoen IA, Ohlsson M, Westerlund U, Svensson M: A new tool in restorative neurosurgery: Creating niches for neuronal stem cells. Neurosurgery 52:1150-1153, 2003.
19. Liu CY, Westerlund U, Svensson M, Moe MC, Varghese M, Berg-Johnsen J, Apuzzo MLJ, Tirrell DA, Langmoen IA: Artificial niches for human adult neural stem cells: Possibility for autologous transplantation therapy. J Hematother Stem Cell Res 12:689-699, 2003.
20. Magee J, Hoffman D, Colbert C, Johnston D: Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annu Rev Physiol 60:327-346, 1998.
21. Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G, Jiang L, Kang J, Nedergaard M, Goldman SA: Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9:439-447, 2003.
22. Rakic P: Adult neurogenesis in mammals: An identity crisis. J Neurosci 22:614-618, 2002.
23. Ramon y Cajal S: Degeneration and Regeneration of the Nervous System. London, Oxford University Press, 1928.
24. Reh TA: Neural stem cells: Form and function. Nat Neurosci 5:392-394, 2002.
25. Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA: In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med 6:271-277, 2000.
26. Schubert D, Heinemann S, Carlisle W, Tarikas H, Kimes B, Patrick J, Steinbach JH, Culp W, Brandt BL: Clonal cell lines from the rat central nervous system. Nature 249:224-227, 1974.
27. Song HJ, Stevens CF, Gage FH: Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci 5:438-445, 2002.
28. + channels. J Neurophysiol 68:985-1000, 1992.
29. Sucher NJ, Brose N, Deitcher DL, Awobuluyi M, Gasic GP, Bading H, Cepko CL, Greenberg ME, Jahn R, Heinemann SF, Lipto SA: Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J Biol Chem 268:22299-22304, 1993.
30. Takamori S, Rhee JS, Rosenmund C, Jahn R: Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature 407:189-194, 2000.
31. Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL: Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A 97:14720-14725, 2000.
32. van Praag H, Schinder A, Christie B, Toni N, Palmer T, Gage F: Functional neurogenesis in the adult hippocampus. Nature 415:1030-1034, 2002.
33. Westerlund U, Moe MC, Varghese M, Berg-Johnsen J, Ohlsson M, Langmoen IA, Svensson M: Stem cells from the adult human brain develop into fully functional neurons in culture. Exp Cell Res 289:378-383, 2003.
34. Wiedenmann B, Franke WW: Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41:1017-1028, 1985.