Hippocampal damage after injection of kainic acid into the rat entorhinal cortex

Brain Research

Volumn 813, Issue 1, 1998, Pages 9-17

  Miettinen, Riitta ^a   Kotti, Tiina ^a   Tuunanen, Jarkko ^b   Toppinen, Ari ^a   Riekkinen Sr , Paavo ^a,b   Halonen, Toivo ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Intracerebral injection; NADPH diaphrose; Somatostatin; Temporal lobe epilepsy

Indexed keywords

KAINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPTIC STATE; GRAND MAL SEIZURE; HIPPOCAMPUS; MALE; NERVE CELL LESION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; TEMPORAL LOBE EPILEPSY;

ANIMALS; CONVULSANTS; DISEASE MODELS, ANIMAL; ENTORHINAL CORTEX; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; MICROINJECTIONS; NADPH DEHYDROGENASE; RATS; RATS, WISTAR; SOMATOSTATIN;

EID: 0032583208     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00915-9     Document Type: Article

References (42)

1. D.G., Amaral, Memory: anatomical organization of candidate brain regions; in: V.B. Mountcastle, F. Blom, S.R. Geiger (Eds.), Handbook of Physiology - The Nervous System, American Physiological Society, Bethesda, MD, 1987, pp. 211-294.
2. Amaral D.G. Emerging principles of intrinsic hippocampal organization. Curr. Opin. Neurobiol. 3:1993;225-229.
3. Ben-Ari Y. Limbic seizures and brain damage produced by kainic acid: mechanism and relevance to human temporal lobe epilepsy. Neuroscience. 14:1985;375-403.
4. Buckmaster P.S., Kunkel D.D., Robbins R.J., Schwartzkroin P.A. Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit. Hippocampus. 4:1994;167-180.
5. Coyle J.T. Neurotoxic action of kainic acid. J. Neurochem. 41:1983;1-11.
6. Dam A.J. Epilepsy and neuron loss in the hippocampus. Epilepsia. 21:1980;617-629.
7. DeGiorgio C.M., Tomiyasu U., Gott P.S., Treiman D. Hippocampal pyramidal cell loss in human status epilepticus. Epilepsia. 33:1992;23-27.
8. Du F., Whetsell W.O. Jr., Abou-Khalil B., Blumenkopf B., Lothman E.W., Schwarcz R. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res. 16:1993;223-233.
9. Du F., Eid T., Lothman E.W., Köhler C., Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J. Neurosci. 15:1995;6301-6313.
10. Falconer M., Serafetinides E., Corsellis J.A.N. Etiology and pathogenesis of temporal lobe epilepsy. Arch. Neurol. 10:1964;233-248.
11. Freund T.F., Ylinen A., Miettinen R., Pitkänen A., Lahtinen H., Baimbridge K.G., Riekkinen P.J. Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability. Brain Res. Bull. 28:1991;27-38.
12. Gallyas F., Wolf J.R., Bottcher H., Zaborsky L. A reliable and sensitive method to localize terminal degeneration and lysosomes in the central nervous system. Stain. Technol. 55:1980;299-306.
13. Halonen T., Kotti T., Tuunanen J., Toppinen A., Miettinen R., Riekkinen P.J. Sr. α2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. Brain Res. 693:1995;217-224.
14. Heinemann U., Zhang C.L., Eder C. Entorhinal cortex-hippocampal interactions in normal and epileptic temporal lobe. Hippocampus. 3:1993;89-98.
15. Insausti R. Comparative anatomy of the entorhinal cortex and hippocampus in mammals. Hippocampus. 3:1993;19-26.
16. Jolkkonen J., Jolkkonen E., Pitkänen A. Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection. Exp. Neurol. 145:1997;141-153.
17. Kotti T., Halonen T., Sirviö J., Riekkinen P. Sr., Miettinen R. Comparison of NADPH diaphorase histochemistry, somatostatin-immunohistochemistry, and silver impregnation in detecting structural and functional impairment in experimental status epilepticus. Neuroscience. 80:1997;105-117.
18. de Lanerolle N.C., Thapar K., Partington J.P., Robbins R., Spencer D.D. Comparison of somatostatin immunoreactivity in epileptogenic and normal human hippocampi. Epilepsia. 28:1987;600-601.
19. Lothman E.W., Collins R.C. Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res. 218:1981;299-318.
20. Magloczky Z., Freund T.F. Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield. Neuroscience. 56:1993;317-336.
21. Magloczky Z., Freund T.F. Delayed cell death in the contralateral hippocampus following kainate injection into the CA3 subfield. Neuroscience. 66:1995;847-860.
22. Miettinen R., Kotti T., Halonen T., Riekkinen P. Sr. NADPH diaphorase-containing nonpyramidal cells in the rat hippocampus exhibit differential sensitivity to kainic acid. Eur. J. Neurosci. 7:1995;1822-1825.
23. Nadler J.V., Perry B.W., Cotman C.W. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature. 271:1978;676-677.
24. Nadler J.V. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sciences. 29:1981;2031-2042.
25. Obata-Tsuto H.L. Light and electron microscopic study of somatostatin-like immunoreactive neurons in the rat hippocampus. Brain Res. Bull. 18:1987;613-620.
26. J.W. Olney, R.C. Collins, R.S. Sloviter, Excitotoxic mechanism of epileptic brain damage, in: A.V. Delgado-Escuta, A.A. Ward Jr., D.M. Woodbury, R.J. Porter (Eds.), Advances in Neurology, Vol. 44, Raven Press, New York, 1986, pp. 857-877.
27. O'Shaughnessy D., Gerber G.J. Damage induced by systemic kainic acid in rats is dependent upon seizure activity - a behavioral and morphological study. Neurotoxicology. 7:1986;187-202.
28. G. Paxinos, C. Watson (Eds.), The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1986.
29. Piredda S., Gale K. A crucial epileptogenic site in the deep prepiriform cortex. Nature. 317:1985;623-625.
30. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32:1972;281-294.
31. Salzman S.K., Lee W.A., Sabato S., Mendez A.A., Agresta C.A., Kelly G. Halothane anesthesia is neuroprotective in experimental spinal cord injury: early hemodynamic mechanisms of action. Res. Commun. Chem. Pathol. Pharmacol. 80:1993;59-81.
32. Schwob J.E., Fuller T., Price J.L., Olney J.W. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study. Neurosience. 5:1980;991-1014.
33. Sloviter R.S. Epileptic brain damage in rats induced by sustained electrical stimulation of the perforant path: I. Acute electrophysiological and light microscopic studies. Brain Res. Bull. 10:1983;675-697.
34. Sloviter R.S. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science. 235:1987;73-76.
35. Sloviter R.S., Nilaver G. Immunocytochemical localization of GABA-, cholecystokinin-, vasoactive intestinal polypeptide-, and somatostatin-like immunoreactivity in the area dentata and hippocampus of the rat. J. Comp. Neurol. 256:1987;24-60.
36. Spencer S.S., Spencer D.D. Entorhinal-hippocampal interactions in medial temporal lobe epilepsy. Epilepsia. 35:1994;721-727.
37. Sperk G., Marksteiner B., Gruber R., Mahata M., Ortler M. Functional changes in neuropeptide y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience. 50:1992;831-846.
38. L.W. Swanson, C. Köhler, A. Björklund, The limbic region: I. The septohippocampal system, in: A. Björklund, T. Hökfelt, L.W. Swanson (Eds.), Handbook of Chemical Neuroanatomy, Vol. 5, Integrated System of the CNS, Part I, Elsevier, Amsterdam, 1987, pp. 125-127.
39. Tremblay E., Ottersen O.P., Rovire C., Ben-Ari Y. Intra-amygdaloid injections of kainic acid: regional metabolic changes and their relation to pathological alterations. Neuroscience. 8:1983;299-315.
40. Valtschanoff J.G., Weinberg R.J., Kharazia V.N., Nakane M., Schmidt H. Neurons in rat hippocampus that synthesize nitric oxide. J. Comp. Neurol. 331:1993;111-121.
41. Witter M.P. Organization of the entorhinal-hippocampal system: a review of current anatomical data. Hippocampus. 3:1993;33-44.
42. Ylinen A., Valjakka A., Lahtinen H., Miettinen R., Freund T., Riekkinen P. Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained stimulation of the perforant path. Neuropeptides. 19:1991;205-211.