메뉴 건너뛰기




Volumn 46, Issue P2, 2014, Pages 326-342

Drosophila models of early onset cognitive disorders and their clinical applications

Author keywords

Cognitive disorders; Dendrites; Diagnostics; Drosophila melanogaster; Intellectual disability; Learning and memory; Mental retardation; Model organism; Neuropsychiatric disorders; Next generation sequencing; Reversible cognitive defects; Synapse; Therapy; Treatment; Whole exome sequencing

Indexed keywords

ANIMAL BEHAVIOR; CIRCADIAN RHYTHM; CLINICAL DECISION MAKING; COGNITIVE DEFECT; DISEASE MODEL; DROSOPHILA; EXECUTIVE FUNCTION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; HIGH THROUGHPUT SCREENING; HUMAN; INTELLECTUAL IMPAIRMENT; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NEUROANATOMY; NEUROPATHOLOGY; NEUROPSYCHIATRY; NEXT GENERATION SEQUENCING; NONHUMAN; REVIEW; RNA INTERFERENCE; ANIMAL; DROSOPHILA MELANOGASTER; GENETICS; INTELLECTUAL DISABILITY; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

EID: 84909959420     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.01.013     Document Type: Review
Times cited : (58)

References (205)
  • 3
    • 84876812210 scopus 로고    scopus 로고
    • Mental health: on the spectrum
    • Adam D. Mental health: on the spectrum. Nature 2013, 496:416-418.
    • (2013) Nature , vol.496 , pp. 416-418
    • Adam, D.1
  • 5
    • 77957742773 scopus 로고    scopus 로고
    • NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome
    • Alves-Sampaio A., Troca-Marin J.A., Montesinos M.L. NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J. Neurosci. 2010, 30:13537-13548.
    • (2010) J. Neurosci. , vol.30 , pp. 13537-13548
    • Alves-Sampaio, A.1    Troca-Marin, J.A.2    Montesinos, M.L.3
  • 7
    • 34247560106 scopus 로고    scopus 로고
    • Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction
    • Amiel J., Rio M., de Pontual L., Redon R., Malan V., Boddaert N., Plouin P., Carter N.P., Lyonnet S., Munnich A., Colleaux L. Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. Am. J. Hum. Genet. 2007, 80:988-993.
    • (2007) Am. J. Hum. Genet. , vol.80 , pp. 988-993
    • Amiel, J.1    Rio, M.2    de Pontual, L.3    Redon, R.4    Malan, V.5    Boddaert, N.6    Plouin, P.7    Carter, N.P.8    Lyonnet, S.9    Munnich, A.10    Colleaux, L.11
  • 8
    • 84868121906 scopus 로고    scopus 로고
    • Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
    • Anderson G.R., Galfin T., Xu W., Aoto J., Malenka R.C., Sudhof T.C. Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:18120-18125.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 18120-18125
    • Anderson, G.R.1    Galfin, T.2    Xu, W.3    Aoto, J.4    Malenka, R.C.5    Sudhof, T.C.6
  • 14
    • 3042647610 scopus 로고    scopus 로고
    • The mGluR theory of fragile X mental retardation
    • Bear M.F., Huber K.M., Warren S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci. 2004, 27:370-377.
    • (2004) Trends Neurosci. , vol.27 , pp. 370-377
    • Bear, M.F.1    Huber, K.M.2    Warren, S.T.3
  • 15
    • 77953812408 scopus 로고    scopus 로고
    • 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future
    • Bellen H.J., Tong C., Tsuda H. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat. Rev. Neurosci. 2010, 11:514-522.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 514-522
    • Bellen, H.J.1    Tong, C.2    Tsuda, H.3
  • 18
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat. Rev. Genet. 2005, 6:9-23.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 9-23
    • Bier, E.1
  • 19
    • 84872871735 scopus 로고    scopus 로고
    • Who is he and what is he to you? Recognition in Drosophila melanogaster
    • Billeter J.-C., Levine J.D. Who is he and what is he to you? Recognition in Drosophila melanogaster. Curr. Opin. Neurobiol. 2013, 23:17-23.
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 17-23
    • Billeter, J.-C.1    Levine, J.D.2
  • 21
    • 67649641820 scopus 로고    scopus 로고
    • BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population
    • Bin J., Madhavan J., Ferrini W., Mok C.A., Billingsley G., Héon E. BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population. Hum. Mutat. 2009, 30:E737-E746.
    • (2009) Hum. Mutat. , vol.30 , pp. E737-E746
    • Bin, J.1    Madhavan, J.2    Ferrini, W.3    Mok, C.A.4    Billingsley, G.5    Héon, E.6
  • 23
    • 69249157781 scopus 로고    scopus 로고
    • Fruit flies and intellectual disability
    • Bolduc F.V., Tully T. Fruit flies and intellectual disability. Fly (Austin) 2009, 3:91-104.
    • (2009) Fly (Austin) , vol.3 , pp. 91-104
    • Bolduc, F.V.1    Tully, T.2
  • 24
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 27
    • 79959532384 scopus 로고    scopus 로고
    • Sleep and synaptic homeostasis: structural evidence in Drosophila
    • Bushey D., Tononi G., Cirelli C. Sleep and synaptic homeostasis: structural evidence in Drosophila. Science 2011, 332:1576-1581.
    • (2011) Science , vol.332 , pp. 1576-1581
    • Bushey, D.1    Tononi, G.2    Cirelli, C.3
  • 29
    • 84867280540 scopus 로고    scopus 로고
    • Treatment of neurodevelopmental disorders in adulthood
    • Castrén E., Elgersma Y., Maffei L., Hagerman R. Treatment of neurodevelopmental disorders in adulthood. J. Neurosci. 2012, 32:14074-14079.
    • (2012) J. Neurosci. , vol.32 , pp. 14074-14079
    • Castrén, E.1    Elgersma, Y.2    Maffei, L.3    Hagerman, R.4
  • 30
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy A.A., Myers M., Hannon G.J., Hammond S.M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Develop. 2002, 16:2491-2496.
    • (2002) Genes Develop. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 31
    • 0024052237 scopus 로고
    • The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    • Caudy M., Grell E.H., Dambly-Chaudiere C., Ghysen A., Jan L.Y., Jan Y.N. The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Develop. 1988, 2:843-852.
    • (1988) Genes Develop. , vol.2 , pp. 843-852
    • Caudy, M.1    Grell, E.H.2    Dambly-Chaudiere, C.3    Ghysen, A.4    Jan, L.Y.5    Jan, Y.N.6
  • 32
    • 41049102573 scopus 로고    scopus 로고
    • Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
    • Chang S., Bray S.M., Li Z., Zarnescu D.C., He C., Jin P., Warren S.T. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 2008, 4:256-263.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 256-263
    • Chang, S.1    Bray, S.M.2    Li, Z.3    Zarnescu, D.C.4    He, C.5    Jin, P.6    Warren, S.T.7
  • 34
    • 77955914539 scopus 로고    scopus 로고
    • Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
    • Chen L.Y., Rex C.S., Babayan A.H., Kramar E.A., Lynch G., Gall C.M., Lauterborn J.C. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J. Neurosci. 2010, 30:10977-10984.
    • (2010) J. Neurosci. , vol.30 , pp. 10977-10984
    • Chen, L.Y.1    Rex, C.S.2    Babayan, A.H.3    Kramar, E.A.4    Lynch, G.5    Gall, C.M.6    Lauterborn, J.C.7
  • 37
    • 84856354305 scopus 로고    scopus 로고
    • In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation
    • Coffee R.L., Williamson A.J., Adkins C.M., Gray M.C., Page T.L., Broadie K. In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Hum. Mol. Genet. 2012, 21:900-915.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 900-915
    • Coffee, R.L.1    Williamson, A.J.2    Adkins, C.M.3    Gray, M.C.4    Page, T.L.5    Broadie, K.6
  • 39
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
    • Psychiatric Genomics Consortium, Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis (GROUP) Consortium Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013, 381:1371-1379.
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 40
    • 84874273358 scopus 로고    scopus 로고
    • Broadening roles for FMRP: big news for big potassium (BK) channels
    • Contractor A. Broadening roles for FMRP: big news for big potassium (BK) channels. Neuron 2013, 77:601-603.
    • (2013) Neuron , vol.77 , pp. 601-603
    • Contractor, A.1
  • 43
    • 84878545717 scopus 로고    scopus 로고
    • Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting
    • Cvetkovska V., Hibbert A.D., Emran F., Chen B.E. Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat. Neurosci. 2013, 16:677-682.
    • (2013) Nat. Neurosci. , vol.16 , pp. 677-682
    • Cvetkovska, V.1    Hibbert, A.D.2    Emran, F.3    Chen, B.E.4
  • 45
  • 47
    • 79953792620 scopus 로고    scopus 로고
    • Traces of Drosophila memory
    • Davis R.L. Traces of Drosophila memory. Neuron 2011, 70:8-19.
    • (2011) Neuron , vol.70 , pp. 8-19
    • Davis, R.L.1
  • 50
    • 0032953770 scopus 로고    scopus 로고
    • Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
    • Devuyst O., Christie P.T., Courtoy P.J., Beauwens R., Thakker R.V. Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease. Hum. Mol. Genet. 1999, 8:247-257.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 247-257
    • Devuyst, O.1    Christie, P.T.2    Courtoy, P.J.3    Beauwens, R.4    Thakker, R.V.5
  • 52
    • 33646227185 scopus 로고    scopus 로고
    • Dendritic pathology in mental retardation: from molecular genetics to neurobiology
    • Dierssen M., Ramakers G.J. Dendritic pathology in mental retardation: from molecular genetics to neurobiology. Genes Brain Behav. 2006, 5(Suppl. 2):48-60.
    • (2006) Genes Brain Behav. , vol.5 , pp. 48-60
    • Dierssen, M.1    Ramakers, G.J.2
  • 54
  • 56
    • 0031923221 scopus 로고    scopus 로고
    • Gene discovery in Drosophila: new insights for learning and memory
    • Dubnau J., Tully T. Gene discovery in Drosophila: new insights for learning and memory. Ann. Rev. Neurosci. 1998, 21:407-444.
    • (1998) Ann. Rev. Neurosci. , vol.21 , pp. 407-444
    • Dubnau, J.1    Tully, T.2
  • 57
    • 0036741796 scopus 로고    scopus 로고
    • GAL4 system in Drosophila: a fly geneticist's Swiss army knife
    • Duffy J.B. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 2002, 34:1-15.
    • (2002) Genesis , vol.34 , pp. 1-15
    • Duffy, J.B.1
  • 58
    • 57649225085 scopus 로고    scopus 로고
    • Reversing neurodevelopmental disorders in adults
    • Ehninger D., Li W., Fox K., Stryker M.P., Silva A.J. Reversing neurodevelopmental disorders in adults. Neuron 2008, 60:950-960.
    • (2008) Neuron , vol.60 , pp. 950-960
    • Ehninger, D.1    Li, W.2    Fox, K.3    Stryker, M.P.4    Silva, A.J.5
  • 62
    • 84909955146 scopus 로고    scopus 로고
    • ENCORE Expertisecentrum voor Erfelijke NeuroCognitieve Ontwikkelingsstoornissen. Rotterdam Erasmus MC.
    • ENCORE, ENCORE Expertisecentrum voor Erfelijke NeuroCognitieve Ontwikkelingsstoornissen. Rotterdam Erasmus MC.
  • 63
    • 67349112908 scopus 로고    scopus 로고
    • Neurogenetic approaches to habituation and dishabituation in Drosophila
    • Engel J.E., Wu C.-F. Neurogenetic approaches to habituation and dishabituation in Drosophila. Neurobiol. Learn. Mem. 2009, 92:166-175.
    • (2009) Neurobiol. Learn. Mem. , vol.92 , pp. 166-175
    • Engel, J.E.1    Wu, C.-F.2
  • 67
    • 0142217946 scopus 로고    scopus 로고
    • Further support for digenic inheritance in Bardet-Biedl syndrome
    • Fauser S., Munz M., Besch D. Further support for digenic inheritance in Bardet-Biedl syndrome. J. Med. Genet. 2003, 40:e104.
    • (2003) J. Med. Genet. , vol.40 , pp. e104
    • Fauser, S.1    Munz, M.2    Besch, D.3
  • 68
    • 0021687895 scopus 로고
    • Neurogenetics and behaviour in insects
    • Fischbach K.-F., Heisenberg M. Neurogenetics and behaviour in insects. J. Exp. Biol. 1984, 112:65-93.
    • (1984) J. Exp. Biol. , vol.112 , pp. 65-93
    • Fischbach, K.-F.1    Heisenberg, M.2
  • 70
  • 71
    • 44949094411 scopus 로고    scopus 로고
    • The dystrophin Dp186 isoform regulates neurotransmitter release at a central synapse in Drosophila
    • Fradkin L.G., Baines R.A., van der Plas M.C., Noordermeer J.N. The dystrophin Dp186 isoform regulates neurotransmitter release at a central synapse in Drosophila. J. Neurosci. 2008, 28:5105-5114.
    • (2008) J. Neurosci. , vol.28 , pp. 5105-5114
    • Fradkin, L.G.1    Baines, R.A.2    van der Plas, M.C.3    Noordermeer, J.N.4
  • 74
    • 0034708076 scopus 로고    scopus 로고
    • A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
    • Guo H.F., Tong J., Hannan F., Luo L., Zhong Y. A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 2000, 403:895-898.
    • (2000) Nature , vol.403 , pp. 895-898
    • Guo, H.F.1    Tong, J.2    Hannan, F.3    Luo, L.4    Zhong, Y.5
  • 78
    • 66449086896 scopus 로고    scopus 로고
    • Understanding the neurogenetics of sleep: progress from Drosophila
    • Harbison S.T., MACKAY T.F.C., Anholt R.R.H. Understanding the neurogenetics of sleep: progress from Drosophila. Trends Genet. TIG 2009, 25:262-269.
    • (2009) Trends Genet. TIG , vol.25 , pp. 262-269
    • Harbison, S.T.1    Mackay, T.F.C.2    Anholt, R.R.H.3
  • 79
    • 80052170163 scopus 로고    scopus 로고
    • MED23 mutation links intellectual disability to dysregulation of immediate early gene expression
    • Hashimoto S., Boissel S., Zarhrate M., Rio M., Munnich A., Egly J.-M., Colleaux L. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. Science 2011, 333:1161-1163.
    • (2011) Science , vol.333 , pp. 1161-1163
    • Hashimoto, S.1    Boissel, S.2    Zarhrate, M.3    Rio, M.4    Munnich, A.5    Egly, J.-M.6    Colleaux, L.7
  • 82
    • 84856578911 scopus 로고    scopus 로고
    • Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model
    • Heulens I., D'Hulst C., Van Dam D., De Deyn P.P., Kooy R.F. Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model. Behav. Brain Res. 2012, 229:244-249.
    • (2012) Behav. Brain Res. , vol.229 , pp. 244-249
    • Heulens, I.1    D'Hulst, C.2    Van Dam, D.3    De Deyn, P.P.4    Kooy, R.F.5
  • 85
    • 84856284034 scopus 로고    scopus 로고
    • Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation
    • Japanese Mental Retardation Consortium
    • Honda S., Satomura S., Hayashi S., Imoto I., Nakagawa E., Goto Y., Inazawa J. Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation. J. Hum. Genet. 2012, 57:73-77. Japanese Mental Retardation Consortium.
    • (2012) J. Hum. Genet. , vol.57 , pp. 73-77
    • Honda, S.1    Satomura, S.2    Hayashi, S.3    Imoto, I.4    Nakagawa, E.5    Goto, Y.6    Inazawa, J.7
  • 86
    • 58949098197 scopus 로고    scopus 로고
    • The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function
    • Hortsch M., Nagaraj K., Godenschwege T.A. The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function. Cell. Mol. Biol. Lett. 2009, 14:57-69.
    • (2009) Cell. Mol. Biol. Lett. , vol.14 , pp. 57-69
    • Hortsch, M.1    Nagaraj, K.2    Godenschwege, T.A.3
  • 88
    • 84893843735 scopus 로고    scopus 로고
    • Gaining insight of fetal brain development with diffusion MRI and histology
    • 00102-00100
    • Huang H., Vasung L. Gaining insight of fetal brain development with diffusion MRI and histology. Int. J. Dev. Neurosci. 2013, 21. 00102-00100.
    • (2013) Int. J. Dev. Neurosci. , vol.21
    • Huang, H.1    Vasung, L.2
  • 91
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka A., Siomi M.C., Siomi H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Develop. 2002, 16:2497-2508.
    • (2002) Genes Develop. , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 93
    • 77951437255 scopus 로고    scopus 로고
    • Branching out: mechanisms of dendritic arborization
    • Jan Y.-N., Jan L.Y. Branching out: mechanisms of dendritic arborization. Nat. Pub. Group 2010, 11:316-328.
    • (2010) Nat. Pub. Group , vol.11 , pp. 316-328
    • Jan, Y.-N.1    Jan, L.Y.2
  • 94
    • 84876520352 scopus 로고    scopus 로고
    • Proteomic profiling in Drosophila reveals potential Dube3a regulation of the actin cytoskeleton and neuronal homeostasis
    • Jensen L., Farook M.F., Reiter L.T. Proteomic profiling in Drosophila reveals potential Dube3a regulation of the actin cytoskeleton and neuronal homeostasis. PLoS One 2013, 8:e61952.
    • (2013) PLoS One , vol.8 , pp. e61952
    • Jensen, L.1    Farook, M.F.2    Reiter, L.T.3
  • 96
    • 67649202108 scopus 로고    scopus 로고
    • Drosophila tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation
    • Jin S., Pan L., Liu Z., Wang Q., Xu Z., Zhang Y.Q. Drosophila tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 2009, 136:1571-1581.
    • (2009) Development , vol.136 , pp. 1571-1581
    • Jin, S.1    Pan, L.2    Liu, Z.3    Wang, Q.4    Xu, Z.5    Zhang, Y.Q.6
  • 97
    • 0029869355 scopus 로고    scopus 로고
    • A screen for genes that function downstream of Ras1 during Drosophila eye development
    • Karim F.D., Chang H.C., Therrien M., Wassarman D.A., Laverty T., Rubin G.M. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 1996, 143:315-329.
    • (1996) Genetics , vol.143 , pp. 315-329
    • Karim, F.D.1    Chang, H.C.2    Therrien, M.3    Wassarman, D.A.4    Laverty, T.5    Rubin, G.M.6
  • 100
    • 0033797735 scopus 로고    scopus 로고
    • Dendritic anomalies in disorders associated with mental retardation
    • Kaufmann W.E., Moser H.W. Dendritic anomalies in disorders associated with mental retardation. Cereb. Cortex 2000, 10:981-991.
    • (2000) Cereb. Cortex , vol.10 , pp. 981-991
    • Kaufmann, W.E.1    Moser, H.W.2
  • 101
    • 84878835421 scopus 로고    scopus 로고
    • Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons
    • Kim J.H., Wang X., Coolon R., Ye B. Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons. Neuron 2013, 78:827-838.
    • (2013) Neuron , vol.78 , pp. 827-838
    • Kim, J.H.1    Wang, X.2    Coolon, R.3    Ye, B.4
  • 109
    • 52949100204 scopus 로고    scopus 로고
    • Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases
    • Krab L.C., Goorden S.M., Elgersma Y. Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases. Trends Genet. 2008, 24:498-510.
    • (2008) Trends Genet. , vol.24 , pp. 498-510
    • Krab, L.C.1    Goorden, S.M.2    Elgersma, Y.3
  • 111
  • 112
    • 33745479882 scopus 로고    scopus 로고
    • Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome
    • Kriaucionis S., Paterson A., Curtis J., Guy J., Macleod N., Bird A. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol. Cell. Biol. 2006, 26:5033-5042.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 5033-5042
    • Kriaucionis, S.1    Paterson, A.2    Curtis, J.3    Guy, J.4    Macleod, N.5    Bird, A.6
  • 114
    • 0347915731 scopus 로고    scopus 로고
    • Structural plasticity and memory. Nature reviews
    • Lamprecht R., LeDoux J. Structural plasticity and memory. Nature reviews. Neuroscience 2004, 5:45-54.
    • (2004) Neuroscience , vol.5 , pp. 45-54
    • Lamprecht, R.1    LeDoux, J.2
  • 116
    • 0345308602 scopus 로고    scopus 로고
    • Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1
    • Lee A., Li W., Xu K., Bogert B.A., Su K., Gao F.B. Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 2003, 130:5543-5552.
    • (2003) Development , vol.130 , pp. 5543-5552
    • Lee, A.1    Li, W.2    Xu, K.3    Bogert, B.A.4    Su, K.5    Gao, F.B.6
  • 117
    • 34249678000 scopus 로고    scopus 로고
    • DXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation
    • Lee N.G., Hong Y.K., Yu S.Y., Han S.Y., Geum D., Cho K.S. dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation. FEBS Lett. 2007, 581:2625-2632.
    • (2007) FEBS Lett. , vol.581 , pp. 2625-2632
    • Lee, N.G.1    Hong, Y.K.2    Yu, S.Y.3    Han, S.Y.4    Geum, D.5    Cho, K.S.6
  • 118
    • 27644517404 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    • Li W., Cui Y., Kushner S.A., Brown R.A., Jentsch J.D., Frankland P.W., Cannon T.D., Silva A.J. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr. Biol. 2005, 15:1961-1967.
    • (2005) Curr. Biol. , vol.15 , pp. 1961-1967
    • Li, W.1    Cui, Y.2    Kushner, S.A.3    Brown, R.A.4    Jentsch, J.D.5    Frankland, P.W.6    Cannon, T.D.7    Silva, A.J.8
  • 119
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 120
    • 58749100670 scopus 로고    scopus 로고
    • The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches
    • Lu Y., Wang F., Li Y., Ferris J., Lee J.A., Gao F.B. The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches. Hum. Mol. Genet. 2009, 18:454-462.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 454-462
    • Lu, Y.1    Wang, F.2    Li, Y.3    Ferris, J.4    Lee, J.A.5    Gao, F.B.6
  • 121
    • 40849126329 scopus 로고    scopus 로고
    • A simple vision-based algorithm for decision making in flying Drosophila
    • Maimon G., Straw A.D., Dickinson M.H. A simple vision-based algorithm for decision making in flying Drosophila. Curr. Biol. 2008, 18:464-470.
    • (2008) Curr. Biol. , vol.18 , pp. 464-470
    • Maimon, G.1    Straw, A.D.2    Dickinson, M.H.3
  • 123
    • 80053346770 scopus 로고    scopus 로고
    • New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye
    • Marrone A.K., Kucherenko M.M., Rishko V.M., Shcherbata H.R. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. BMC Neurosci. 2011, 12:93.
    • (2011) BMC Neurosci. , vol.12 , pp. 93
    • Marrone, A.K.1    Kucherenko, M.M.2    Rishko, V.M.3    Shcherbata, H.R.4
  • 125
    • 14544279308 scopus 로고    scopus 로고
    • Research resources for Drosophila: the expanding universe
    • Matthews K.A., Kaufman T.C., Gelbart W.M. Research resources for Drosophila: the expanding universe. Nat. Rev. Genet. 2005, 6:179-193.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 179-193
    • Matthews, K.A.1    Kaufman, T.C.2    Gelbart, W.M.3
  • 128
    • 84855508881 scopus 로고    scopus 로고
    • When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders
    • Menet J.S., Rosbash M. When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr. Opin. Neurobiol. 2011, 21:849-857.
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 849-857
    • Menet, J.S.1    Rosbash, M.2
  • 129
    • 84871783676 scopus 로고    scopus 로고
    • The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons
    • Miao S., Chen R., Ye J., Tan G.H., Li S., Zhang J., Jiang Y.H., Xiong Z.Q. The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons. J. Neurosci. 2013, 33:327-333.
    • (2013) J. Neurosci. , vol.33 , pp. 327-333
    • Miao, S.1    Chen, R.2    Ye, J.3    Tan, G.H.4    Li, S.5    Zhang, J.6    Jiang, Y.H.7    Xiong, Z.Q.8
  • 130
    • 3042735950 scopus 로고    scopus 로고
    • Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants
    • Michel C.I., Kraft R., Restifo L.L. Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants. J. Neurosci. 2004, 24:5798-5809.
    • (2004) J. Neurosci. , vol.24 , pp. 5798-5809
    • Michel, C.I.1    Kraft, R.2    Restifo, L.L.3
  • 131
    • 0036844229 scopus 로고    scopus 로고
    • Multiple hits during early embryonic development: digenic diseases and holoprosencephaly
    • Ming J.E., Muenke M. Multiple hits during early embryonic development: digenic diseases and holoprosencephaly. Am. J. Hum. Genet. 2002, 71:1017-1032.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1017-1032
    • Ming, J.E.1    Muenke, M.2
  • 134
    • 84861683430 scopus 로고    scopus 로고
    • Research domain criteria: cognitive systems, neural circuits, and dimensions of behavior
    • Morris S.E., Cuthbert B.N. Research domain criteria: cognitive systems, neural circuits, and dimensions of behavior. Dialog. Clin. Neurosci. 2012, 14:29-37.
    • (2012) Dialog. Clin. Neurosci. , vol.14 , pp. 29-37
    • Morris, S.E.1    Cuthbert, B.N.2
  • 135
    • 84861481027 scopus 로고    scopus 로고
    • Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo
    • Mouri K., Horiuchi S.Y., Uemura T. Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo. Genes Cells 2012, 17:509-524.
    • (2012) Genes Cells , vol.17 , pp. 509-524
    • Mouri, K.1    Horiuchi, S.Y.2    Uemura, T.3
  • 137
    • 37449016136 scopus 로고    scopus 로고
    • Rho-linked genes and neurological disorders
    • Nadif Kasri N., Van Aelst L. Rho-linked genes and neurological disorders. Pflugers Arch. 2008, 455:787-797.
    • (2008) Pflugers Arch. , vol.455 , pp. 787-797
    • Nadif Kasri, N.1    Van Aelst, L.2
  • 139
  • 145
    • 72449122397 scopus 로고    scopus 로고
    • Addiction: flies hit the skids
    • Ojelade S.A., Rothenfluh A. Addiction: flies hit the skids. Curr. Biol. 2009, 19:R1110-R1111.
    • (2009) Curr. Biol. , vol.19 , pp. R1110-R1111
    • Ojelade, S.A.1    Rothenfluh, A.2
  • 147
    • 33845545435 scopus 로고    scopus 로고
    • The modular nature of genetic diseases
    • Oti M., Brunner H.G. The modular nature of genetic diseases. Clin. Genet. 2007, 71:1-11.
    • (2007) Clin. Genet. , vol.71 , pp. 1-11
    • Oti, M.1    Brunner, H.G.2
  • 149
    • 6944247816 scopus 로고    scopus 로고
    • The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation
    • Pan L., Zhang Y.Q., Woodruff E., Broadie K. The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr. Biol. 2004, 14:1863-1870.
    • (2004) Curr. Biol. , vol.14 , pp. 1863-1870
    • Pan, L.1    Zhang, Y.Q.2    Woodruff, E.3    Broadie, K.4
  • 150
    • 79955749505 scopus 로고    scopus 로고
    • Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
    • Pandey U.B., Nichols C.D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol. Rev. 2011, 63:411-436.
    • (2011) Pharmacol. Rev. , vol.63 , pp. 411-436
    • Pandey, U.B.1    Nichols, C.D.2
  • 151
    • 84873282879 scopus 로고    scopus 로고
    • A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons
    • Patel A.B., Hays S.A., Bureau I., Huber K.M., Gibson J.R. A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons. J. Neurosci. 2013, 33:2593-2604.
    • (2013) J. Neurosci. , vol.33 , pp. 2593-2604
    • Patel, A.B.1    Hays, S.A.2    Bureau, I.3    Huber, K.M.4    Gibson, J.R.5
  • 153
    • 84872860756 scopus 로고    scopus 로고
    • Courtship behavior in Drosophila melanogaster: towards a 'courtship connectome'
    • Pavlou H.J., Goodwin S.F. Courtship behavior in Drosophila melanogaster: towards a 'courtship connectome'. Curr. Opin. Neurobiol. 2013, 23:76-83.
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 76-83
    • Pavlou, H.J.1    Goodwin, S.F.2
  • 154
    • 42149171410 scopus 로고    scopus 로고
    • A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion
    • Pielage J., Cheng L., Fetter R.D., Carlton P.M., Sedat J.W., Davis G.W. A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion. Neuron 2008, 58:195-209.
    • (2008) Neuron , vol.58 , pp. 195-209
    • Pielage, J.1    Cheng, L.2    Fetter, R.D.3    Carlton, P.M.4    Sedat, J.W.5    Davis, G.W.6
  • 155
    • 7744236541 scopus 로고    scopus 로고
    • The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task
    • Putz G., Bertolucci F., Raabe T., Zars T., Heisenberg M. The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. J. Neurosci. 2004, 24:9745-9751.
    • (2004) J. Neurosci. , vol.24 , pp. 9745-9751
    • Putz, G.1    Bertolucci, F.2    Raabe, T.3    Zars, T.4    Heisenberg, M.5
  • 156
    • 35548991458 scopus 로고    scopus 로고
    • Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms
    • Rachidi M., Lopes C. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci. Res. 2007, 59:349-369.
    • (2007) Neurosci. Res. , vol.59 , pp. 349-369
    • Rachidi, M.1    Lopes, C.2
  • 158
    • 20544468497 scopus 로고    scopus 로고
    • The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain
    • Reeve S.P., Bassetto L., Genova G.K., Kleyner Y., Leyssen M., Jackson F.R., Hassan B.A. The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 2005, 15:1156-1163.
    • (2005) Curr. Biol. , vol.15 , pp. 1156-1163
    • Reeve, S.P.1    Bassetto, L.2    Genova, G.K.3    Kleyner, Y.4    Leyssen, M.5    Jackson, F.R.6    Hassan, B.A.7
  • 160
    • 52949098733 scopus 로고    scopus 로고
    • Genetics of intellectual disability
    • Ropers H.H. Genetics of intellectual disability. Curr. Opin. Genet. Dev. 2008, 18:241-250.
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 241-250
    • Ropers, H.H.1
  • 162
    • 33751332515 scopus 로고    scopus 로고
    • Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition
    • Ruiz-Canada C., Budnik V. Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition. Int. Rev. Neurobiol. 2006, 75:1-31.
    • (2006) Int. Rev. Neurobiol. , vol.75 , pp. 1-31
    • Ruiz-Canada, C.1    Budnik, V.2
  • 163
    • 33751341341 scopus 로고    scopus 로고
    • Synaptic cytoskeleton at the neuromuscular junction
    • Ruiz-Canada C., Budnik V. Synaptic cytoskeleton at the neuromuscular junction. Int. Rev. Neurobiol. 2006, 75:217-236.
    • (2006) Int. Rev. Neurobiol. , vol.75 , pp. 217-236
    • Ruiz-Canada, C.1    Budnik, V.2
  • 166
    • 0037523396 scopus 로고    scopus 로고
    • CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein
    • Schenck A., Bardoni B., Langmann C., Harden N., Mandel J.L., Giangrande A. CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 2003, 38:887-898.
    • (2003) Neuron , vol.38 , pp. 887-898
    • Schenck, A.1    Bardoni, B.2    Langmann, C.3    Harden, N.4    Mandel, J.L.5    Giangrande, A.6
  • 168
    • 38849130750 scopus 로고    scopus 로고
    • PiggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
    • Schuldiner O., Berdnik D., Levy J.M., Wu J.S., Luginbuhl D., Gontang A.C., Luo L. piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning. Devlop. Cell 2008, 14:12.
    • (2008) Devlop. Cell , vol.14 , pp. 12
    • Schuldiner, O.1    Berdnik, D.2    Levy, J.M.3    Wu, J.S.4    Luginbuhl, D.5    Gontang, A.C.6    Luo, L.7
  • 170
    • 81755172860 scopus 로고    scopus 로고
    • Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila
    • Shao L., Shuai Y., Wang J., Feng S., Lu B., Li Z., Zhao Y., Wang L., Zhong Y. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:18831-18836.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 18831-18836
    • Shao, L.1    Shuai, Y.2    Wang, J.3    Feng, S.4    Lu, B.5    Li, Z.6    Zhao, Y.7    Wang, L.8    Zhong, Y.9
  • 171
    • 67650217503 scopus 로고    scopus 로고
    • Automated measurement of Drosophila jump reflex habituation and its use for mutant screening
    • Sharma P., Keane J., O'Kane C.J., Asztalos Z. Automated measurement of Drosophila jump reflex habituation and its use for mutant screening. J. Neurosci. Methods 2009, 182:43-48.
    • (2009) J. Neurosci. Methods , vol.182 , pp. 43-48
    • Sharma, P.1    Keane, J.2    O'Kane, C.J.3    Asztalos, Z.4
  • 172
    • 33744463377 scopus 로고    scopus 로고
    • Dunces and da Vincis: the genetics of learning and memory in Drosophila
    • Skoulakis E.M., Grammenoudi S. Dunces and da Vincis: the genetics of learning and memory in Drosophila. Cell. Mol. Life Sci. 2006, 63:975-988.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 975-988
    • Skoulakis, E.M.1    Grammenoudi, S.2
  • 173
    • 77950268592 scopus 로고    scopus 로고
    • Social interactions in simple model systems
    • Sokolowski M.B. Social interactions in simple model systems. Neuron 2010, 65:780-794.
    • (2010) Neuron , vol.65 , pp. 780-794
    • Sokolowski, M.B.1
  • 176
    • 44449130390 scopus 로고    scopus 로고
    • Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning
    • Tessier C.R., Broadie K. Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development 2008, 135:1547-1557.
    • (2008) Development , vol.135 , pp. 1547-1557
    • Tessier, C.R.1    Broadie, K.2
  • 177
    • 0033756219 scopus 로고    scopus 로고
    • A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila
    • Therrien M., Morrison D.K., Wong A.M., Rubin G.M. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics 2000, 156:1231-1242.
    • (2000) Genetics , vol.156 , pp. 1231-1242
    • Therrien, M.1    Morrison, D.K.2    Wong, A.M.3    Rubin, G.M.4
  • 178
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signalling and synaptic plasticity
    • Thomas G.M., Huganir R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 2004, 5:173-183.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 179
    • 84880769695 scopus 로고    scopus 로고
    • Shaping the nervous system: role of the core planar cell polarity genes
    • Tissir F., Goffinet A.M. Shaping the nervous system: role of the core planar cell polarity genes. Nat. Rev. Neurosci. 2013, 14:525-535.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 525-535
    • Tissir, F.1    Goffinet, A.M.2
  • 181
    • 42449163029 scopus 로고    scopus 로고
    • Analysis of the trajectory of Drosophila melanogaster in a circular open field arena
    • Valente D., Golani I., Mitra P.P. Analysis of the trajectory of Drosophila melanogaster in a circular open field arena. PLoS One 2007, 2.
    • (2007) PLoS One , pp. 2
    • Valente, D.1    Golani, I.2    Mitra, P.P.3
  • 182
    • 84875237257 scopus 로고    scopus 로고
    • Drosophila strategies to study psychiatric disorders
    • van Alphen B., van Swinderen B. Drosophila strategies to study psychiatric disorders. Brain Res. Bull. 2011, 92:1-11.
    • (2011) Brain Res. Bull. , vol.92 , pp. 1-11
    • van Alphen, B.1    van Swinderen, B.2
  • 183
    • 80755168331 scopus 로고    scopus 로고
    • Genetic and epigenetic networks in intellectual disabilities
    • van Bokhoven H. Genetic and epigenetic networks in intellectual disabilities. Ann. Rev. Genet. 2011, 45:81-104.
    • (2011) Ann. Rev. Genet. , vol.45 , pp. 81-104
    • van Bokhoven, H.1
  • 186
    • 84863970074 scopus 로고    scopus 로고
    • De novo mutations in human genetic disease
    • Veltman J.A., Brunner H.G. De novo mutations in human genetic disease. Nat. Rev. Genet. 2012, 13:565-575.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 565-575
    • Veltman, J.A.1    Brunner, H.G.2
  • 187
    • 59949096873 scopus 로고    scopus 로고
    • Ensembl compara gene trees: complete, duplication-aware phylogenetic trees in vertebrates
    • Vilella A.J., Severin J., Ureta-Vidal A., Heng L., Durbin R., Birney E. Ensembl compara gene trees: complete, duplication-aware phylogenetic trees in vertebrates. Genome Res. 2009, 19:327-335.
    • (2009) Genome Res. , vol.19 , pp. 327-335
    • Vilella, A.J.1    Severin, J.2    Ureta-Vidal, A.3    Heng, L.4    Durbin, R.5    Birney, E.6
  • 189
    • 84857417996 scopus 로고    scopus 로고
    • Drosophila as a model for MECP2 gain of function in neurons
    • Vonhoff F., Williams A., Ryglewski S., Duch C. Drosophila as a model for MECP2 gain of function in neurons. PLoS One 2012, 7:21.
    • (2012) PLoS One , vol.7 , pp. 21
    • Vonhoff, F.1    Williams, A.2    Ryglewski, S.3    Duch, C.4
  • 190
    • 43649087291 scopus 로고    scopus 로고
    • Synaptic defects in a Drosophila model of congenital muscular dystrophy
    • Wairkar Y.P., Fradkin L.G., Noordermeer J.N., DiAntonio A. Synaptic defects in a Drosophila model of congenital muscular dystrophy. J. Neurosci. 2008, 28:3781-3789.
    • (2008) J. Neurosci. , vol.28 , pp. 3781-3789
    • Wairkar, Y.P.1    Fradkin, L.G.2    Noordermeer, J.N.3    DiAntonio, A.4
  • 191
    • 0033761489 scopus 로고    scopus 로고
    • Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein
    • Wan L., Dockendorff T.C., Jongens T.A., Dreyfuss G. Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol. Cell. Biol. 2000, 20:8536-8547.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8536-8547
    • Wan, L.1    Dockendorff, T.C.2    Jongens, T.A.3    Dreyfuss, G.4
  • 192
  • 195
    • 41849132794 scopus 로고    scopus 로고
    • High heritability for a composite index of children's activity level measures
    • Wood A.C., Rijsdijk F., Saudino K.J., Asherson P., Kuntsi J. High heritability for a composite index of children's activity level measures. Behav. Genet. 2008, 38:266-276.
    • (2008) Behav. Genet. , vol.38 , pp. 266-276
    • Wood, A.C.1    Rijsdijk, F.2    Saudino, K.J.3    Asherson, P.4    Kuntsi, J.5
  • 197
    • 24344457816 scopus 로고    scopus 로고
    • Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
    • Yan Q.J., Rammal M., Tranfaglia M., Bauchwitz R.P. Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 2005, 49:1053-1066.
    • (2005) Neuropharmacology , vol.49 , pp. 1053-1066
    • Yan, Q.J.1    Rammal, M.2    Tranfaglia, M.3    Bauchwitz, R.P.4
  • 198
  • 199
    • 77949915907 scopus 로고    scopus 로고
    • Functional modules, mutational load and human genetic disease
    • Zaghloul N.A., Katsanis N. Functional modules, mutational load and human genetic disease. Trends Genet. 2010, 26:168-176.
    • (2010) Trends Genet. , vol.26 , pp. 168-176
    • Zaghloul, N.A.1    Katsanis, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.