메뉴 건너뛰기




Volumn 16, Issue 6, 2013, Pages 677-682

Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting

Author keywords

[No Author keywords available]

Indexed keywords

DOWN SYNDROME CELL ADHESION MOLECULE PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 84878545717     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3396     Document Type: Article
Times cited : (59)

References (49)
  • 1
    • 35548991458 scopus 로고    scopus 로고
    • Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms
    • Rachidi, M. & Lopes, C. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci. Res. 59, 349-369 (2007)
    • (2007) Neurosci. Res , vol.59 , pp. 349-369
    • Rachidi, M.1    Lopes, C.2
  • 2
    • 53849110899 scopus 로고    scopus 로고
    • Fragile X syndrome: Loss of local mRNA regulation alters synaptic development and function
    • Bassell, G.J. & Warren, S.T. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 60, 201-214 (2008)
    • (2008) Neuron , vol.60 , pp. 201-214
    • Bassell, G.J.1    Warren, S.T.2
  • 3
    • 84871413198 scopus 로고    scopus 로고
    • FMRP targets distinct mRNA sequence elements to regulate protein expression
    • Ascano, M. Jr. et al. FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature 492, 382-386 (2012)
    • (2012) Nature , vol.492 , pp. 382-386
    • Ascano Jr., M.1
  • 4
    • 18044379515 scopus 로고    scopus 로고
    • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    • Brown, V. et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107, 477-487 (2001)
    • (2001) Cell , vol.107 , pp. 477-487
    • Brown, V.1
  • 5
    • 79960779323 scopus 로고    scopus 로고
    • FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
    • Darnell, J.C. et al. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146, 247-261 (2011)
    • (2011) Cell , vol.146 , pp. 247-261
    • Darnell, J.C.1
  • 6
    • 0019419703 scopus 로고
    • Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome. A quantitative and qualitative Golgi study
    • Takashima, S., Becker, L.E., Armstrong, D.L. & Chan, F. Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome. A quantitative and qualitative Golgi study. Brain Res. 225, 1-21 (1981)
    • (1981) Brain Res , vol.225 , pp. 1-21
    • Takashima, S.1    Becker, L.E.2    Armstrong, D.L.3    Chan, F.4
  • 7
    • 0032127166 scopus 로고    scopus 로고
    • 10 years of genomics, chromosome 21 and Down syndrome
    • Antonarakis, S.E. 10 years of genomics, chromosome 21 and Down syndrome. Genomics 51, 1-16 (1998)
    • (1998) Genomics , vol.51 , pp. 1-16
    • Antonarakis, S.E.1
  • 8
    • 0031964775 scopus 로고    scopus 로고
    • DSCAM: A novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system
    • Yamakawa, K. et al. DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum. Mol. Genet. 7, 227-237 (1998)
    • (1998) Hum Mol. Genet , vol.7 , pp. 227-237
    • Yamakawa, K.1
  • 9
    • 0028341315 scopus 로고
    • Down syndrome phenotypes: The consequences of chromosomal imbalance
    • Korenberg, J.R. et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc. Natl. Acad. Sci. USA 91, 4997-5001 (1994)
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4997-5001
    • Korenberg, J.R.1
  • 10
    • 18544383778 scopus 로고    scopus 로고
    • Down syndrome congenital heart disease: A narrowed region and a candidate gene
    • Barlow, G.M. et al. Down syndrome congenital heart disease: a narrowed region and a candidate gene. Genet. Med. 3, 91-101 (2001)
    • (2001) Genet. Med , vol.3 , pp. 91-101
    • Barlow, G.M.1
  • 11
    • 0032955777 scopus 로고    scopus 로고
    • A contiguous 3-Mb sequence-ready map in the S3-MX region on 21q22.2 based on high-throughput nonisotopic library screenings
    • Hildmann, T. et al. A contiguous 3-Mb sequence-ready map in the S3-MX region on 21q22.2 based on high-throughput nonisotopic library screenings. Genome Res. 9, 360-372 (1999)
    • (1999) Genome Res , vol.9 , pp. 360-372
    • Hildmann, T.1
  • 12
    • 77957742773 scopus 로고    scopus 로고
    • NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome
    • Alves-Sampaio, A., Troca-Marin, J.A. & Montesinos, M.L. NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J. Neurosci. 30, 13537-13548 (2010)
    • (2010) J. Neurosci , vol.30 , pp. 13537-13548
    • Alves-Sampaio, A.1    Troca-Marin, J.A.2    Montesinos, M.L.3
  • 13
    • 58849147630 scopus 로고    scopus 로고
    • Dscam and DSCAM: Complex genes in simple animals, complex animals yet simple genes
    • Schmucker, D. & Chen, B. Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes. Genes Dev. 23, 147-156 (2009)
    • (2009) Genes Dev , vol.23 , pp. 147-156
    • Schmucker, D.1    Chen, B.2
  • 14
    • 0019312271 scopus 로고
    • The projection of sensory neurons in the central nervous system of Drosophila: Choice of the appropriate pathway
    • Ghysen, A. The projection of sensory neurons in the central nervous system of Drosophila: choice of the appropriate pathway. Dev. Biol. 78, 521-541 (1980)
    • (1980) Dev. Biol , vol.78 , pp. 521-541
    • Ghysen, A.1
  • 15
    • 33646131607 scopus 로고    scopus 로고
    • The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila
    • Chen, B.E. et al. The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell 125, 607-620 (2006)
    • (2006) Cell , vol.125 , pp. 607-620
    • Chen, B.E.1
  • 16
    • 79953875431 scopus 로고    scopus 로고
    • Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation
    • Neufeld, S.Q., Hibbert, A.D. & Chen, B.E. Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation. Mol. Brain 4, 15 (2011)
    • (2011) Mol. Brain , vol.4 , pp. 15
    • Neufeld, S.Q.1    Hibbert, A.D.2    Chen, B.E.3
  • 17
    • 0028178791 scopus 로고
    • The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    • Hinz, U., Giebel, B. & Campos-Ortega, J.A. The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87 (1994)
    • (1994) Cell , vol.76 , pp. 77-87
    • Hinz, U.1    Giebel, B.2    Campos-Ortega, J.A.3
  • 18
    • 0027377580 scopus 로고
    • FMR1 protein: Conserved RNP family domains and selective RNA binding
    • Ashley, C.T. Jr., Wilkinson, K.D., Reines, D. & Warren, S.T. FMR1 protein: conserved RNP family domains and selective RNA binding. Science 262, 563-566 (1993)
    • (1993) Science , vol.262 , pp. 563-566
    • Ashley Jr., C.T.1    Wilkinson, K.D.2    Reines, D.3    Warren, S.T.4
  • 19
    • 17844372504 scopus 로고    scopus 로고
    • From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome
    • Bagni, C. & Greenough, W.T. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat. Rev. Neurosci. 6, 376-387 (2005)
    • (2005) Nat. Rev. Neurosci , vol.6 , pp. 376-387
    • Bagni, C.1    Greenough, W.T.2
  • 20
    • 34247485947 scopus 로고    scopus 로고
    • A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
    • Zalfa, F. et al. A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat. Neurosci. 10, 578-587 (2007)
    • (2007) Nat. Neurosci , vol.10 , pp. 578-587
    • Zalfa, F.1
  • 21
    • 50849092487 scopus 로고    scopus 로고
    • The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
    • Didiot, M.C. et al. The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res. 36, 4902-4912 (2008)
    • (2008) Nucleic Acids Res , vol.36 , pp. 4902-4912
    • Didiot, M.C.1
  • 22
    • 0031892814 scopus 로고    scopus 로고
    • Single neuron mosaics of the Drosophila gigas mutant project beyond normal targets and modify behavior
    • Canal, I., Acebes, A. & Ferrus, A. Single neuron mosaics of the Drosophila gigas mutant project beyond normal targets and modify behavior. J. Neurosci. 18, 999-1008 (1998)
    • (1998) J. Neurosci , vol.18 , pp. 999-1008
    • Canal, I.1    Acebes, A.2    Ferrus, A.3
  • 23
    • 0024593686 scopus 로고
    • Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila
    • Corfas, G. & Dudai, Y. Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila. J. Neurosci. 9, 56-62 (1989)
    • (1989) J. Neurosci , vol.9 , pp. 56-62
    • Corfas, G.1    Dudai, Y.2
  • 24
    • 0027405726 scopus 로고
    • Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster
    • Phillis, R.W. et al. Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster. Genetics 133, 581-592 (1993)
    • (1993) Genetics , vol.133 , pp. 581-592
    • Phillis, R.W.1
  • 25
    • 0018849060 scopus 로고
    • Genetic control of sensory connections in Drosophila
    • Vandervorst, P. & Ghysen, A. Genetic control of sensory connections in Drosophila. Nature 286, 65-67 (1980)
    • (1980) Nature , vol.286 , pp. 65-67
    • Vandervorst, P.1    Ghysen, A.2
  • 26
    • 68749103452 scopus 로고    scopus 로고
    • Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
    • Darnell, J.C., Fraser, C.E., Mostovetsky, O. & Darnell, R.B. Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Hum. Mol. Genet. 18, 3164-3177 (2009)
    • (2009) Hum. Mol. Genet , vol.18 , pp. 3164-3177
    • Darnell, J.C.1    Fraser, C.E.2    Mostovetsky, O.3    Darnell, R.B.4
  • 27
    • 17444384228 scopus 로고    scopus 로고
    • Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
    • Darnell, J.C. et al. Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev. 19, 903-918 (2005)
    • (2005) Genes Dev , vol.19 , pp. 903-918
    • Darnell, J.C.1
  • 28
    • 0034625260 scopus 로고    scopus 로고
    • Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    • Schmucker, D. et al. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101, 671-684 (2000)
    • (2000) Cell , vol.101 , pp. 671-684
    • Schmucker, D.1
  • 29
    • 24044455869 scopus 로고    scopus 로고
    • Genome sequencing in microfabricated high-density picolitre reactors
    • Margulies, M. et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-380 (2005)
    • (2005) Nature , vol.437 , pp. 376-380
    • Margulies, M.1
  • 30
    • 60449105945 scopus 로고    scopus 로고
    • Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation
    • Li, H.L. et al. Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation. Neuron 61, 527-540 (2009)
    • (2009) Neuron , vol.61 , pp. 527-540
    • Li, H.L.1
  • 31
    • 80155171417 scopus 로고    scopus 로고
    • A protein complex network of Drosophila melanogaster
    • Guruharsha, K.G. et al. A protein complex network of Drosophila melanogaster. Cell 147, 690-703 (2011)
    • (2011) Cell , vol.147 , pp. 690-703
    • Guruharsha, K.G.1
  • 32
    • 24944454976 scopus 로고    scopus 로고
    • Extensive diversity of Ig-superfamily proteins in the immune system of insects
    • Watson, F.L. et al. Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309, 1874-1878 (2005)
    • (2005) Science , vol.309 , pp. 1874-1878
    • Watson, F.L.1
  • 34
    • 33845307238 scopus 로고    scopus 로고
    • Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos
    • Monzo, K. et al. Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. Proc. Natl. Acad. Sci. USA 103, 18160-18165 (2006)
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 18160-18165
    • Monzo, K.1
  • 35
    • 29644436341 scopus 로고    scopus 로고
    • Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp
    • Stetler, A. et al. Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Hum. Mol. Genet. 15, 87-96 (2006)
    • (2006) Hum. Mol. Genet , vol.15 , pp. 87-96
    • Stetler, A.1
  • 36
    • 33745874084 scopus 로고    scopus 로고
    • AgDscam a hypervariable immunoglobulin domain-containing receptor of the Anopheles gambiae innate immune system
    • Dong, Y., Taylor, H. & Dimopoulos, G. AgDscam, a hypervariable immunoglobulin domain-containing receptor of the Anopheles gambiae innate immune system. PLoS Biol. 4, e229 (2006)
    • (2006) PLoS Biol , vol.4
    • Dong, Y.1    Taylor, H.2    Dimopoulos, G.3
  • 37
    • 79955764824 scopus 로고    scopus 로고
    • The Down syndrome critical region regulates retinogeniculate refinement
    • Blank, M. et al. The Down syndrome critical region regulates retinogeniculate refinement. J. Neurosci. 31, 5764-5776 (2011)
    • (2011) J. Neurosci , vol.31 , pp. 5764-5776
    • Blank, M.1
  • 38
    • 81755187305 scopus 로고    scopus 로고
    • Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects
    • Grossman, T.R. et al. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 7, e1002344 (2011)
    • (2011) PLoS Genet , vol.7
    • Grossman, T.R.1
  • 39
    • 33646227185 scopus 로고    scopus 로고
    • Dendritic pathology in mental retardation: From molecular genetics to neurobiology
    • Dierssen, M. & Ramakers, G.J. Dendritic pathology in mental retardation: from molecular genetics to neurobiology. Genes Brain Behav. 5 (suppl. 2), 48-60 (2006)
    • (2006) Genes Brain Behav. , vol.5 , Issue.SUPPL. 2 , pp. 48-60
    • Dierssen, M.1    Ramakers, G.J.2
  • 40
    • 0033797735 scopus 로고    scopus 로고
    • Dendritic anomalies in disorders associated with mental retardation
    • Kaufmann, W.E. & Moser, H.W. Dendritic anomalies in disorders associated with mental retardation. Cereb. Cortex 10, 981-991 (2000)
    • (2000) Cereb. Cortex , vol.10 , pp. 981-991
    • Kaufmann, W.E.1    Moser, H.W.2
  • 41
    • 0035879180 scopus 로고    scopus 로고
    • Abnormal development of dendritic spines in FMR1 knock-out mice
    • Nimchinsky, E.A., Oberlander, A.M. & Svoboda, K. Abnormal development of dendritic spines in FMR1 knock-out mice. J Neurosci 21, 5139-5146 (2001)
    • (2001) J Neurosci , vol.21 , pp. 5139-5146
    • Nimchinsky, E.A.1    Oberlander, A.M.2    Svoboda, K.3
  • 42
    • 0037071905 scopus 로고    scopus 로고
    • Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    • Dockendorff, T.C. et al. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34, 973-984 (2002)
    • (2002) Neuron , vol.34 , pp. 973-984
    • Dockendorff, T.C.1
  • 43
    • 52949109182 scopus 로고    scopus 로고
    • Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
    • Bolduc, F.V., Bell, K., Cox, H., Broadie, K.S. & Tully, T. Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nat. Neurosci. 11, 1143-1145 (2008)
    • (2008) Nat. Neurosci , vol.11 , pp. 1143-1145
    • Bolduc, F.V.1    Bell, K.2    Cox, H.3    Broadie, K.S.4    Tully, T.5
  • 44
    • 0035977134 scopus 로고    scopus 로고
    • Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    • Zhang, Y.Q. et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107, 591-603 (2001)
    • (2001) Cell , vol.107 , pp. 591-603
    • Zhang, Y.Q.1
  • 45
    • 10744233572 scopus 로고    scopus 로고
    • Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
    • Parks, A.L. et al. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat. Genet. 36, 288-292 (2004)
    • (2004) Nat. Genet , vol.36 , pp. 288-292
    • Parks, A.L.1
  • 46
    • 33845698104 scopus 로고    scopus 로고
    • Pacman: A BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster
    • Venken, K.J., He, Y., Hoskins, R.A. & Bellen, H.J. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314, 1747-1751 (2006)
    • (2006) Science , vol.314 , pp. 1747-1751
    • Venken, K.J.1    He, Y.2    Hoskins, R.A.3    Bellen, H.J.4
  • 47
    • 20544468497 scopus 로고    scopus 로고
    • The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain
    • Reeve, S.P. et al. The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15, 1156-1163 (2005)
    • (2005) Curr. Biol , vol.15 , pp. 1156-1163
    • Reeve, S.P.1
  • 48
    • 84867696915 scopus 로고    scopus 로고
    • ELAV Mediates 3′ UTR extension in the drosophila nervous system
    • Hilgers, V., Lemke, S.B. & Levine, M. ELAV mediates 3′ UTR extension in the Drosophila nervous system. Genes Dev. 26, 2259-2264 (2012)
    • (2012) Genes Dev , vol.26 , pp. 2259-2264
    • Hilgers, V.1    Lemke, S.B.2    Levine, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.