Understanding the neurogenetics of sleep: progress from Drosophila

Trends in Genetics

Volumn 25, Issue 6, 2009, Pages 262-269

  Harbison, Susan T ^a   Mackay, Trudy F C ^a   Anholt, Robert R H ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHAKER POTASSIUM CHANNEL;

BRAIN REGION; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; ENERGY CONSERVATION; GENE FUNCTION; GENE IDENTIFICATION; GENE REGULATORY NETWORK; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC VARIABILITY; LEARNING; MAMMAL; MEMORY CONSOLIDATION; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SLEEP; TRANSCRIPTION REGULATION;

ANIMALS; DROSOPHILA; SLEEP;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 66449086896     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2009.04.003     Document Type: Review

References (57)

1. Cirelli C., and Tononi G. Is sleep essential?. PLoS Biol. 6 (2008) e216
2. Siegel J.M. Do all animals sleep?. Trends Neurosci. 31 (2008) 208-213
3. Rechtschaffen A., et al. Sleep deprivation in the rat: X. Integration and discussion of the findings. Sleep 12 (1989) 68-87
4. Shaw P.J. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417 (2002) 287-291
5. Shaw P.J., and Franken P. Perchance to dream: solving the mystery of sleep through genetic analysis. J. Neurobiol. 54 (2003) 179-202
6. Shaw P.J., et al. Correlates of sleep and waking in Drosophila melanogaster. Science 287 (2000) 1834-1837
7. Hendricks J.C., et al. Rest in Drosophila is a sleep-like state. Neuron 25 (2000) 129-138
8. Zepelin H. Mammalian sleep. In: Kryger M.H., et al. (Ed). Principles and Practice of Sleep Medicine (1994), W. B. Saunders Company 69-80
9. Berger R.J., and Phillips N.H. Energy conservation and sleep. Behav. Brain Res. 69 (1995) 65-73
10. Benington J.H., and Heller H.C. Restoration of brain energy metabolism as the function of sleep. Prog. Neurobiol. 45 (1995) 347-360
11. Tononi G., and Cirelli C. Sleep and synaptic homeostasis: a hypothesis. Brain Res. Bull. 62 (2003) 143-150
12. Stickgold R. Sleep-dependent memory consolidation. Nature 437 (2005) 1272-1278
13. Ganguly-Fitzgerald I., et al. Waking experience affects sleep need in Drosophila. Science 313 (2006) 1775-1781
14. McBride S.M., et al. Mushroom body ablation impairs short-term memory and long-term memory of courtship conditioning in Drosophila melanogaster. Neuron 24 (1999) 967-977
15. Liu W., et al. amnesiac regulates sleep onset and maintenance in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 372 (2008) 798-803
16. Seugnet L., et al. D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila. Curr. Biol. 18 (2008) 1110-1117
17. Fujii S., et al. Nocturnal male sex drive in Drosophila. Curr. Biol. 17 (2007) 244-251
18. Cirelli C. Cellular consequences of sleep deprivation in the brain. Sleep Med. Rev. 10 (2006) 307-321
19. Bushey D., et al. The Drosophila Fragile X mental retardation gene regulates sleep need. J. Neurosci. 29 (2009) 1948-1961
20. Pan L., et al. The Drosophila Fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr. Biol. 14 (2004) 1863-1870
21. Gilestro G.F., et al. Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science 324 (2009) 109-112
22. Donlea J.M., et al. Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324 (2009) 105-108
23. Cirelli C., et al. Reduced sleep in Drosophila Shaker mutants. Nature 434 (2005) 1087-1092
24. Koh K., et al. Identification of SLEEPLESS, a sleep-promoting factor. Science 321 (2008) 372-376
25. Bushey D., et al. Drosophila hyperkinetic mutants have reduced sleep and impaired memory. J. Neurosci. 27 (2007) 5384-5393
26. Wu M.N., et al. A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep 31 (2008) 465-472
27. Yamamoto A., et al. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 12393-12398
28. Tafti M., and Franken P. Genetic dissection of sleep. J. Appl. Physiol. 92 (2002) 1339-1347
29. Cirelli C., et al. Sleep and wakefulness modulate gene expression in Drosophila. J. Neurochem. 94 (2005) 1411-1419
30. Zimmerman J.E., et al. Multiple mechanisms limit the duration of wakefulness in Drosophila brain. Physiol. Genomics 27 (2006) 337-350
31. Williams J.A., et al. Interaction between sleep and the immune response in Drosophila: A role for the NFκB Relish. Sleep 30 (2007) 389-400
32. Harbison S.T., et al. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat. Genet. 41 (2009) 371-375
33. Chintapalli V.R., et al. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat. Genet. 39 (2007) 715-720
34. Sambandan D., et al. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Genetics 179 (2008) 1079-1088
35. Ayroles J.F., et al. Systems genetics of complex traits in Drosophila melanogaster. Nat. Genet. 41 (2009) 299-307
36. Pitman J.L., et al. A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature 441 (2006) 753-756
37. Hendricks J.C., et al. A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat. Neurosci. 4 (2001) 1108-1115
38. Joiner W.J., et al. Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441 (2006) 757-760
39. Crocker A., and Sehgal A. Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms. J. Neurosci. 28 (2008) 9377-9385
40. Foltenyi K., et al. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat. Neurosci. 10 (2007) 1160-1167
41. Renn S.C.P., et al. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 99 (1999) 791-802
42. Parisky K.M., et al. PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron 60 (2008) 672-682
43. Sheeba V., et al. Large ventral lateral neurons modulate sleep and arousal in Drosophila. Curr. Biol. 18 (2008) 1537-1545
44. Shang Y., et al. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 19587-19594
45. Sheeba V., et al. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J. Neurophysiol. 99 (2007) 976-988
46. Chung B.Y., et al. The GABA-A receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr. Biol. 19 (2009) 386-390
47. A receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat. Neurosci. 11 (2008) 354-359
48. Seugnet L., et al. Identification of a biomarker for sleep drive in flies and humans. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 19913-19918
49. Douglas C.L., et al. Sleep in Kcna2 knockout mice. BMC Biol. 5 (2007) 42
50. Zimmerman J.E., et al. A video method to study Drosophila sleep. Sleep 31 (2008) 1587-1598
51. Nitz D.A., et al. Electrophysiological correlates of rest and activity in Drosophila melanogaster. Curr. Biol. 12 (2002) 1934-1940
52. Alvarez J.D. Genetic basis for circadian rhythms in mammals. In: Sehgal A. (Ed). Molecular Biology of Circadian Rhythms (2004), John Wiley and Sons, Inc. 93-140
53. Harbison S.T., and Sehgal A. Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics 178 (2008) 2341-2360
54. Grima B., et al. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature 431 (2004) 869-873
55. Koh K., et al. A Drosophila model for age-associated changes in sleep:wake cycles. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 13843-13847
56. van Swinderen B. A succession of anesthetic endpoints in the Drosophila brain. J. Neurobiol. 66 (2006) 1195-1211
57. Knutson K.L., and Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann. N. Y. Acad. Sci. 1129 (2008) 287-304