Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

Cell

Volumn 107, Issue 5, 2001, Pages 591-603

  Zhang, Yong Q ^a   Bailey, Adina M ^b   Matthies, Heinrich J G ^a   Renden, Robert B ^a   Smith, Mark A ^a   Speese, Sean D ^a   Rubin, Gerald M ^b   Broadie, Kendal ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA FRAGILE X RELATED PROTEIN; INSECT PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 5; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EXPERIMENTAL MODEL; FRAGILE X SYNDROME; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOPRECIPITATION; MICROTUBULE; MUTANT; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SYNAPSE;

ANIMALIA; DROSOPHILA; INSECTA;

EID: 0035977134     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00589-X     Document Type: Article

References (37)

1. FMR1 protein: Conserved RNP family domains and selective RNA binding
2. Human and murine FMR-1: Alternative splicing and translational initiation downstream of the CGG-repeat
3. Genetic dissection of behavior
4. A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila
5. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
6. Functional assays of the peripheral and central nervous system
7. Development of the embryonic neuromuscular synapse of Drosophila melanogaster
8. Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein
9. Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
10. The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
11. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
12. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
13. Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes
14. The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal
15. Analysis of neocortex in three males with the fragile X syndrome
16. Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
17. The central complex of Drosophila melanogaster is involved in flight control: Studies on mutants and mosaics of the gene ellipsoid body open
18. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination
19. Understanding the molecular basis of fragile X syndrome
20. The fragile X mental retardation protein is associated with ribosomes
21. Evidence that fragile X mental retardation protein is a negative regulator of translation
22. The fragile X mental retardation protein inhibits translation via interacting with mRNA
23. Abnormal development of dendritic spines in FMR1 knock-out mice
24. (Over)correction of FMR1 deficiency with YAC transgenics: Behavioral and physical features
25. Genetic studies in Drosophila: Vesicle pools and cytoskeleton-based regulation of synaptic transmission
26. Integrin-mediated regulation of synaptic morphology, transmission, and plasticity
27. Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth
28. Systematic gain-of-function genetics in Drosophila
29. The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
30. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
31. FMRP is associated to the ribosomes via RNA
32. Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis
33. Characterization and localization of the FMR-1 gene product associated with fragile X syndrome
34. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
35. Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein
36. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation