Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8536-8547

  Wan, L ^a   Dockendorff, T C ^a   Jongens, T A ^a   Dreyfuss, G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSECT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DROSOPHILA MELANOGASTER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CLONING, MOLECULAR; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; FRAGILE X MENTAL RETARDATION PROTEIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RNA; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033761489     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8536-8547.2000     Document Type: Article

References (74)

1. Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain
2. Programmed cell death during Drosophila embryogenesis
3. Expression of FMR1, FXR1, and FXR2 genes in human prenatal tissues
4. FMR1 protein: Conserved RNP family domains and selective RNA binding
5. Enhanced Fmr-1 expression in testis
6. Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye
7. Physical mapping across the fragile X: Hypermethylation and clinical expression of the fragile X syndrome
8. Regulation of the complex pattern of sevenless expression in the developing Drosophila eye
9. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
10. Conserved structures and diversity of functions of RNA-binding proteins
11. Seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye
12. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex
13. Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells
14. The appearance of acetylated alpha-tubulin during early development and cellular differentiation in Xenopus
15. Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
16. Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1
17. A point mutation in the FMR-1 gene associated with fragile X mental retardation
18. IAP family proteins - Suppressors of apoptosis
19. The fragile X syndrome
20. The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
21. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
22. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
23. Modeling human neurodegenerative diseases in Drosophila: On a wing and a prayer
24. A nuclear role for the fragile X mental retardation protein
25. Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
26. Fragile X syndrome without CCG amplification has an FMR1 deletion
27. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
28. Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island
29. Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice
30. Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome
31. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68
32. A screen for genes that function downstream of Ras1 during Drosophila eye development
33. Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis
34. The fragile X mental retardation protein is associated with ribosomes
35. Primary structure and binding activity of the hnRNP U protein: Binding RNA through RGG box
36. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n
37. A putative Drosophila homolog of the Huntington's disease gene
38. Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1
39. Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1
40. The role of the genome project in determining gene function: Insights from model organisms
41. Three-dimensional structure and stability of the KH domain: Molecular insights into the fragile X syndrome
42. Fragile X syndrome: A unique mutation in man
43. Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome
44. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
45. Absence of expression of the FMR-1 gene in fragile X syndrome
46. Immunological methods for purification and characterization of heterogeneous nuclear ribonucleo-protein particles
47. A genetic screen for novel components of the Ras/mitogen-activated protein kinase signaling pathway that interact with the van gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
48. Gene overexpression in studies of Saccharomyces cerevisiae
49. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
50. Systematic gain-of-function genetics in Drosophila
51. Genetic transformation of Drosophila with transposable element vectors
52. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
53. Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome
54. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif
55. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
56. FXR1, an autosomal homolog of the fragile X mental retardation gene
57. Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them
58. Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms
59. Transposition of cloned P elements into Drosophila germ line chromosomes
60. Presenilin is required for activity and nuclear access of Notch in Drosophila
61. FMRP is associated to the ribosomes via RNA
62. Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis
63. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila
64. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
65. Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis
66. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation
67. A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome
68. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
69. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster
70. Fragile X genotype characterized by an unstable region of DNA
71. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2