Molecular dynamics characterization of five pathogenic factor X mutants associated with decreased catalytic activity

Biochemistry

Volumn 53, Issue 44, 2014, Pages 6992-7001

  Abdel Azeim, Safwat ^a   Oliva, Romina ^b   Chermak, Edrisse ^a   De Cristofaro, Raimondo ^c   Cavallo, Luigi ^a,d  

^a KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^b UNIVERSITY OF NAPLES PARTHENOPE   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BLOOD; DEFECTS; ENZYME ACTIVITY; MOLECULAR DYNAMICS; RIGIDITY;

BLOOD CLOTS; BLOOD COAGULATION; CATALYTIC DOMAINS; MOLECULAR DYNAMICS SIMULATIONS; PATHOGENIC FACTORS; PATHOGENIC MUTATION; PROTEIN MOTION; SUBSTRATE RECOGNITION;

CATALYST ACTIVITY;

BLOOD CLOTTING FACTOR 10; CHYMOTRYPSINOGEN;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTANT; PRINCIPAL COMPONENT ANALYSIS; RIGIDITY; WILD TYPE; BIOCATALYSIS; CHEMISTRY; GENETICS; HUMAN; MISSENSE MUTATION; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS;

BIOCATALYSIS; CATALYTIC DOMAIN; FACTOR X; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS;

EID: 84909606545     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500770p     Document Type: Article

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