Substrate Recognition and Motion Mode Analyses of PFV Integrase in Complex with Viral DNA via Coarse-Grained Models

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Hu, Jianping ^a   Liu, Ming ^b   Tang, Dianyong ^a   Chang, Shan ^c  

^a LESHAN NORMAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; VIRUS DNA;

ANISOTROPY NETWORK MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; DNA DETERMINATION; DNA SEQUENCE; ENZYME SUBSTRATE COMPLEX; GAUSSIAN NETWORK MODEL; IC 50; MATHEMATICAL MODEL; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN DNA BINDING; PROTEIN DOMAIN; RELIABILITY; SEQUENCE ALIGNMENT; SPUMA VIRUS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; DNA, VIRAL; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; ISOENZYMES; KETO ACIDS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SPUMAVIRUS; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

AIDS VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN SPUMARETROVIRUS;

EID: 84872851728     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054929     Document Type: Article

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