Coagulation factor IXa: The relaxed conformation of Tyr99 blocks substrate binding

Structure

Volumn 7, Issue 8, 1999, Pages 989-996

  Hopfner, Karl Peter ^a,c   Lang, Anja ^b   Karcher, Annette ^b,c   Sichler, Katrin ^b   Kopetzki, Erhard ^b   Brandsetter, Hans ^a   Huber, Robert ^a   Bode, Wolfram ^a   Engh, Richard A ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Crystal structure; Drug design; Recombinant proteins; Substrate binding sites

Indexed keywords

4 AMINOBENZAMIDINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; CHROMOGENIC SUBSTRATE; DEXTRO PHENYLALANYLPROLYLARGINYL CHLOROMETHYL KETONE; HYDROXYL GROUP; RECOMBINANT PROTEIN; SERINE PROTEINASE; TISSUE PLASMINOGEN ACTIVATOR; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

EID: 0010333946     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(99)80125-7     Document Type: Article

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