Substitution of asparagine for arginine 347 of recombinant factor Xa markedly reduces factor Va binding

Biochemistry

Volumn 39, Issue 11, 2000, Pages 2861-2867

  Rudolph, Amy E ^a,b   Porche Sorbet, Rhonda ^a   Miletich, Joseph P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; ARGININE; ASPARAGINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; HEPARIN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PROTHROMBIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ANIMALS; ANTITHROMBIN III; ARGININE; ASPARAGINE; BINDING, COMPETITIVE; ENZYME ACTIVATION; ENZYME INHIBITORS; FACTOR VA; FACTOR XA; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPIDS; POINT MUTATION; PROTEIN BINDING; PROTHROMBIN; RECOMBINANT PROTEINS; SURFACE PROPERTIES;

EID: 0034696578     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992379b     Document Type: Article

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