Integrative genomics of chronic obstructive pulmonary disease

Biochemical and Biophysical Research Communications

Volumn 452, Issue 2, 2014, Pages 276-286

  Hobbs, Brian D ^a   Hersh, Craig P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chronic obstructive pulmonary disease; Genomewide association study; Genomics; Network medicine

Indexed keywords

BIOLOGICAL MARKER; MACROPHAGE ELASTASE; MICRORNA;

CHROMOSOME 11Q; CHROMOSOME 14Q; CHROMOSOME 15Q; CHROMOSOME 19Q; CHROMOSOME 1Q; CHROMOSOME 4Q; CHRONIC OBSTRUCTIVE LUNG DISEASE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOMICS; HUMAN; LUNG FUNCTION; NONHUMAN; PHENOTYPE; REVIEW; CLASSIFICATION; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; GENOMEWIDE ASSOCIATION STUDY; HUMAN CHROMOSOME; LUNG; NETWORK MEDICINE; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY;

CHRONIC OBSTRUCTIVE PULMONARY DISEASE; GENOMEWIDE ASSOCIATION STUDY; GENOMICS; NETWORK MEDICINE;

CHROMOSOMES, HUMAN; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENOMICS; HUMANS; LUNG; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84908609302     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.07.086     Document Type: Review

References (123)

1. R. Lozano, M. Naghavi, K. Foreman, et al., Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010, Lancet 380 (2012) 2095-2128.
2. B. Burrows, R.J. Knudson, M.G. Cline, et al., Quantitative relationships between cigarette smoking and ventilatory function, Am. Rev. Respir. Dis. 115 (1977) 195-205.
3. D.L. DeMeo, E.K. Silverman, Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk, Thorax 59 (2004) 259-264.
4. E.K. Silverman, R.A. Sandhaus, Clinical practice. Alpha1-antitrypsin deficiency, N. Engl. J. Med. 360 (2009) 2749-2757.
5. C.P. Hersh, D.L. DeMeo, E.K. Silverman, Chronic obstructive pulmonary disease, in: E.K. Silverman, S.D. Shapiro, D.A. Lomas, S.T. Weiss (Eds.), Respiratory Genetics, Hodder Arnold, New York, 2005, pp. 253-296.
6. J.J. Zhou, M.H. Cho, P.J. Castaldi, et al., Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers, Am. J. Respir. Crit. Care Med. 188 (2013) 941-947.
7. M.H. Cho, M.L. McDonald, X. Zhou, et al., Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis, Lancet Respir. Med. 2 (2014) 214-225.
8. T.A. Manolio, F.S. Collins, N.J. Cox, et al., Finding the missing heritability of complex diseases, Nature 461 (2009) 747-753.
9. E.K. Silverman, J. Loscalzo, Network medicine approaches to the genetics of complex diseases, Discov. Med. 14 (2012) 143-152.
10. S.G. Pillai, D. Ge, G. Zhu, et al., A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci, PLoS Genet. 5 (2009) e1000421.
11. G. Zhu, L. Warren, J. Aponte, et al., The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations, Am. J. Respir. Crit. Care Med. 176 (2007) 167-173.
12. B.D. Patel, H.O. Coxson, S.G. Pillai, et al., Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 178 (2008) 500-505.
13. A. Fishman, F. Martinez, K. Naunheim, et al., A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema, N. Engl. J. Med. 348 (2003) 2059-2073.
14. B. Bell, C.L. Rose, H. Damon, The normative aging study: an interdisciplinary and longitudinal study of health and aging, Aging Hum. Dev. 3 (1972) 5-17.
15. D.L. DeMeo, T. Mariani, S. Bhattacharya, et al., Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene, Am. J. Hum. Genet. 85 (2009) 493-502.
16. S. Bhattacharya, S. Srisuma, D.L. Demeo, et al., Molecular biomarkers for quantitative and discrete COPD phenotypes, Am. J. Respir. Cell Mol. Biol. 40 (2009) 359-367.
17. T.E. Thorgeirsson, F. Geller, P. Sulem, et al., A variant associated with nicotine dependence, lung cancer and peripheral arterial disease, Nature 452 (2008) 638-642.
18. Tobacco and Genetics Consortium, Genome-wide meta-analyses identify multiple loci associated with smoking behavior, Nat. Genet. 42 (2010) 441-447.
19. T.E. Thorgeirsson, D.F. Gudbjartsson, I. Surakka, et al., Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior, Nat. Genet. 42 (2010) 448-453.
20. M. Siedlinski, M.H. Cho, P. Bakke, et al., Genome-wide association study of smoking behaviours in patients with COPD, Thorax 66 (2011) 894-902.
21. M. Siedlinski, D. Tingley, P.J. Lipman, et al., Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility, Hum. Genet. 132 (2013) 431-441.
22. J.B. Wilk, T.H. Chen, D.J. Gottlieb, et al., A genome-wide association study of pulmonary function measures in the Framingham heart study, PLoS Genet. 5 (2009) e1000429.
23. D.B. Hancock, M. Eijgelsheim, J.B. Wilk, et al., Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function, Nat. Genet. 42 (2010) 45-52.
24. E. Repapi, I. Sayers, L.V. Wain, et al., Genome-wide association study identifies five loci associated with lung function, Nat. Genet. 42 (2010) 36-44.
25. X. Zhou, R.M. Baron, M. Hardin, et al., Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP, Hum. Mol. Genet. 21 (2012) 1325-1335.
26. X. Zhou, W. Qiu, J.F. Sathirapongsasuti, et al., Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells, Genomics 101 (2013) 263-272.
27. J. Vestbo, W. Anderson, H.O. Coxson, et al., Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE), Eur. Respir. J. 31 (2008) 869-873.
28. M.H. Cho, N. Boutaoui, B.J. Klanderman, et al., Variants in FAM13A are associated with chronic obstructive pulmonary disease, Nat. Genet. 42 (2010) 200-202.
29. E.A. Regan, J.E. Hokanson, J.R. Murphy, et al., Genetic epidemiology of COPD (COPDGene) study design, COPD 7 (2010) 32-43.
30. E.K. Silverman, H.A. Chapman, J.M. Drazen, et al., Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis, Am. J. Respir. Crit. Care Med. 157 (1998) 1770-1778.
31. M.H. Cho, P.J. Castaldi, E.S. Wan, et al., A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13, Hum. Mol. Genet. 21 (2012) 947-957.
32. N.L. Saccone, R.C. Culverhouse, T.H. Schwantes-An, et al., Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD, PLoS Genet. 6 (2010) e1001053.
33. R.D. Hautamaki, D.K. Kobayashi, R.M. Senior, et al., Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice, Science 277 (1997) 2002-2004.
34. G.M. Hunninghake, M.H. Cho, Y. Tesfaigzi, et al., MMP12, lung function, and COPD in high-risk populations, N. Engl. J. Med. 361 (2009) 2599-2608.
35. T. Ishii, R.T. Abboud, A.M. Wallace, et al., Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema, Eur. Respir. J. 43 (2014) 82-91.
36. M. Soler Artigas, D.W. Loth, L.V. Wain, et al., Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function, Nat. Genet. 43 (2011) 1082-1090.
37. D.B. Hancock, M.S. Artigas, S.A. Gharib, et al., Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function, PLoS Genet. 8 (2012) e1003098.
38. J.B. Wilk, N.R. Shrine, L.R. Loehr, et al., Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction, Am. J. Respir. Crit. Care Med. 186 (2012) 622-632.
39. N.N. Hansel, I. Ruczinski, N. Rafaels, et al., Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD, Hum. Genet. 132 (2013) 79-90.
40. M. Imboden, E. Bouzigon, I. Curjuric, et al., Genome-wide association study of lung function decline in adults with and without asthma, J. Allergy Clin. Immunol. 129 (2012) 1218-1228.
41. C.P. Hersh, F.L. Jacobson, R. Gill, et al., Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease, COPD 4 (2007) 331-337.
42. A.E. Dijkstra, J. Smolonska, M. van den Berge, et al., Susceptibility to chronic mucus hypersecretion, a genome wide association study, PLoS One 9 (2014) e91621.
43. X. Kong, M.H. Cho, W. Anderson, et al., Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema, Am. J. Respir. Crit. Care Med. 183 (2011) 43-49.
44. A. Manichaikul, E.A. Hoffman, J. Smolonska, et al., Genome-wide study of percent emphysema on computed tomography in the general population. The multi-ethnic study of atherosclerosis lung/SNP health association resource study, Am. J. Respir. Crit. Care Med. 189 (2014) 408-418.
45. A.M. Schols, J. Slangen, L. Volovics, et al., Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 157 (1998) 1791-1797.
46. C. Landbo, E. Prescott, P. Lange, et al., Prognostic value of nutritional status in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 160 (1999) 1856-1861.
47. B.R. Celli, C.G. Cote, J.M. Marin, et al., The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease, N. Engl. J. Med. 350 (2004) 1005-1012.
48. E.S. Wan, J.E. Hokanson, J.R. Murphy, et al., Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study, Am. J. Respir. Crit. Care Med. 184 (2011) 57-63.
49. T.M. Frayling, N.J. Timpson, M.N. Weedon, et al., A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity, Science 316 (2007) 889-894.
50. M. Hardin, M. Cho, M.L. McDonald, et al., The clinical and genetic features of COPD-asthma overlap syndrome, Eur. Respir. J. (2014) [Epub ahead of print].
51. M.L. McDonald, M.H. Cho, I.C. Sorheim, et al., Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol. (2014) [Epub ahead of print].
52. H.A. Golpon, C.D. Coldren, M.R. Zamora, et al., Emphysema lung tissue gene expression profiling, Am. J. Respir. Cell Mol. Biol. 31 (2004) 595-600.
53. A. Spira, J. Beane, V. Pinto-Plata, et al., Gene expression profiling of human lung tissue from smokers with severe emphysema, Am. J. Respir. Cell Mol. Biol. 31 (2004) 601-610.
54. W. Ning, C.J. Li, N. Kaminski, et al., Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease, Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 14895-14900.
55. Z.-H. Chen, H.P. Kim, S.W. Ryter, et al., Identifying targets for COPD treatment through gene expression profiling, Int. J. Chronic. Obstruct. Pulm. Dis. 3 (2008) 359-370.
56. I.M. Wang, S. Stepaniants, Y. Boie, et al., Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer, Am. J. Respir. Crit. Care Med. 177 (2008) 402-411.
57. J.C. Celedon, C. Lange, B.A. Raby, et al., The transforming growth factor-β1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD), Hum. Mol. Genet. 13 (2004) 1649-1656.
58. D.L. Demeo, T.J. Mariani, C. Lange, et al., The SERPINE2 gene is associated with chronic obstructive pulmonary disease, Am. J. Hum. Genet. 78 (2006) 253-264.
59. J.E. Zeskind, M.E. Lenburg, A. Spira, Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management, Proc. Am. Thorac. Soc. 5 (2008) 834-841.
60. M. Ashburner, C.A. Ball, J.A. Blake, et al., Gene ontology: tool for the unification of biology. The gene ontology consortium, Nat. Genet. 25 (2000) 25-29.
61. A. Subramanian, P. Tamayo, V.K. Mootha, et al., Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 15545-15550.
62. S.M. Francis, J.E. Larsen, S.J. Pavey, et al., Expression profiling identifies genes involved in emphysema severity, Respir. Res. 10 (2009) 81.
63. S.M. Savarimuthu Francis, J.E. Larsen, S.J. Pavey, et al., Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD, PLoS One 6 (2011) e17442.
64. J.D. Campbell, J.E. McDonough, J.E. Zeskind, et al., A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK, Genome Med. 4 (2012) 67.
65. J. Lamb, E.D. Crawford, D. Peck, et al., The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease, Science 313 (2006) 1929-1935.
66. K. Steiling, M. van den Berge, K. Hijazi, et al., A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment, Am. J. Respir. Crit. Care Med. 187 (2013) 933-942.
67. M. van den Berge, K. Steiling, W. Timens, et al., Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity, Thorax 69 (2014) 14-23.
68. J.S. Edmiston, K.J. Archer, M.J. Scian, et al., Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers, Biomarkers 15 (2010) 715-730.
69. T.M. Bahr, G.J. Hughes, M. Armstrong, et al., Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol. 49 (2013) 316-323.
70. S. Poliska, E. Csanky, A. Szanto, et al., Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function, Respiration 81 (2011) 499-510.
71. S. Bhattacharya, S. Tyagi, S. Srisuma, et al., Peripheral blood gene expression profiles in COPD subjects, J. Clin. Bioinformatics 1 (2011) 12.
72. D.P. Bartel, MicroRNAs: target recognition and regulatory functions, Cell 136 (2009) 215-233.
73. L.V. Wain, I. Sayers, M. Soler Artigas, et al., Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction, PLoS Genet. 10 (2014) e1004314.
74. D.M. Ryan, T.L. Vincent, J. Salit, et al., Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2, PLoS One 9 (2014) e88051.
75. J. Beane, J. Vick, F. Schembri, et al., Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq, Cancer Prev. Res. (Phila.) 4 (2011) 803-817.
76. N.R. Hackett, M.W. Butler, R. Shaykhiev, et al., RNA-seq quantification of the human small airway epithelium transcriptome, BMC Genomics 13 (2012) 82.
77. G. Wang, Z. Xu, R. Wang, et al., Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers, BMC Med. Genomics 5 (2012) 21.
78. M.E. Ezzie, M. Crawford, J.H. Cho, et al., Gene expression networks in COPD: microRNA and mRNA regulation, Thorax 67 (2012) 122-131.
79. M. Kanehisa, S. Goto, KEGG: kyoto encyclopedia of genes and genomes, Nucleic Acids Res. 28 (2000) 27-30.
80. S.A. Christenson, C.A. Brandsma, J.D. Campbell, et al., MiR-638 regulates gene expression networks associated with emphysematous lung destruction, Genome Med. 5 (2013) 114.
81. V.G. Cheung, R.S. Spielman, K.G. Ewens, et al., Mapping determinants of human gene expression by regional and genome-wide association, Nature 437 (2005) 1365-1369.
82. B.E. Stranger, A.C. Nica, M.S. Forrest, et al., Population genomics of human gene expression, Nat. Genet. 39 (2007) 1217-1224.
83. W. Qiu, M.H. Cho, J.H. Riley, et al., Genetics of sputum gene expression in chronic obstructive pulmonary disease, PLoS One 6 (2011) e24395.
84. M. Lamontagne, C. Couture, D.S. Postma, et al., Refining susceptibility loci of chronic obstructive pulmonary disease with lung eQTLs, PLoS One 8 (2013) e70220.
85. A.P. Feinberg, Epigenetics at the epicenter of modern medicine, JAMA 299 (2008) 1345-1350.
86. P.A. Jones, Functions of DNA methylation: islands, start sites, gene bodies and beyond, Nat. Rev. Genet. 13 (2012) 484-492.
87. E.S. Wan, W. Qiu, A. Baccarelli, et al., Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome, Hum. Mol. Genet. 21 (2012) 3073-3082.
88. L.P. Breitling, R. Yang, B. Korn, et al., Tobacco-smoking-related differential DNA methylation: 27K discovery and replication, Am. J. Hum. Genet. 88 (2011) 450-457.
89. W. Qiu, A. Baccarelli, V.J. Carey, et al., Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function, Am. J. Respir. Crit. Care Med. 185 (2012) 373-381.
90. E.S. Wan, W. Qiu, A. Baccarelli, et al., Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 186 (2012) 1248-1255.
91. E.A. Vucic, R. Chari, K.L. Thu, et al., DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways, Am. J. Respir. Cell Mol. Biol. 50 (2014) 912-922.
92. A. Agusti, D.D. Sin, Biomarkers in COPD, Clin. Chest Med. 35 (2014) 131-141.
93. R. Faner, R. Tal-Singer, J.H. Riley, et al., Lessons from ECLIPSE: a review of COPD biomarkers, Thorax 69 (2014) 666-672.
94. D.K. Kim, M.H. Cho, C.P. Hersh, et al., Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 186 (2012) 1238-1247.
95. R.P. Bowler, T.M. Bahr, G. Hughes, et al., Integrative omics approach identifies interleukin-16 as a biomarker of emphysema, OMICS 17 (2013) 619-626.
96. B. Burrows, C.M. Fletcher, B.E. Heard, et al., The emphysematous and bronchial types of chronic airways obstruction. A clinicopathological study of patients in London and Chicago, Lancet 1 (1966) 830-835.
97. A. Agusti, P.M. Calverley, B. Celli, et al., Characterisation of COPD heterogeneity in the ECLIPSE cohort, Respir. Res. 11 (2010) 122.
98. S.I. Rennard, J. Vestbo, The many "small COPDs": COPD should be an orphan disease, Chest 134 (2008) 623-627.
99. P.J. Castaldi, J. Dy, J. Ross, et al., Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema, Thorax 69 (2014) 415-422.
100. P.J. Castaldi, M.H. Cho, M. Cohn, et al., The COPD genetic association compendium: a comprehensive online database of COPD genetic associations, Hum. Mol. Genet. 19 (2010) 526-534.
101. C.P. Hersh, D.L. Demeo, C. Lange, et al., Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations, Am. J. Respir. Cell Mol. Biol. 33 (2005) 71-78.
102. P. Jia, S. Zheng, J. Long, et al., DmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks, Bioinformatics 27 (2011) 95-102.
103. G. Fehringer, G. Liu, L. Briollais, et al., Comparison of pathway analysis approaches using lung cancer GWAS data sets, PLoS One 7 (2012) e31816.
104. M. Holden, S. Deng, L. Wojnowski, et al., GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies, Bioinformatics 24 (2008) 2784-2785.
105. A. Arning, M. Hiersche, A. Witten, et al., A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke, Blood 120 (2012) 5231-5236.
106. S. Han, B.Z. Yang, H.R. Kranzler, et al., Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence, Am. J. Hum. Genet. 93 (2013) 1027-1034.
107. G. Pelaia, R. Terracciano, A. Vatrella, et al., Application of proteomics and peptidomics to COPD, BioMed Res. Int. 2014 (2014) 764581.
108. S. Snowden, S.E. Dahlen, C.E. Wheelock, Application of metabolomics approaches to the study of respiratory diseases, Bioanalysis 4 (2012) 2265-2290.
109. J.R. Wagner, S. Busche, B. Ge, et al., The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts, Genome Biol. 15 (2014) R37.
110. D. Couper, L.M. LaVange, M. Han, et al., Design of the subpopulations and intermediate outcomes in COPD study (SPIROMICS), Thorax 69 (2014) 491-494.
111. T. Haferlach, A. Kohlmann, L. Wieczorek, et al., Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the international microarray innovations in leukemia study group, J. Clin. Oncol. 28 (2010) 2529-2537.
112. J.S. Reis-Filho, L. Pusztai, Gene expression profiling in breast cancer: classification, prognostication, and prediction, Lancet 378 (2011) 1812-1823.
113. M. Civelek, A.J. Lusis, Systems genetics approaches to understand complex traits, Nat. Rev. Genet. 15 (2014) 34-48.
114. J. Vestbo, S.S. Hurd, A.G. Agusti, et al., Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary, Am. J. Respir. Crit. Care Med. 187 (2013) 347-365.
115. B.J. Carolan, A. Heguy, B.G. Harvey, et al., Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers, Cancer Res. 66 (2006) 10729-10740.
116. S. Pierrou, P. Broberg, R.A. O'Donnell, et al., Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 175 (2007) 577-586.
117. Z. Ammous, N.R. Hackett, M.W. Butler, et al., Variability in small airway epithelial gene expression among normal smokers, Chest 133 (2008) 1344-1353.
118. A.E. Tilley, B.G. Harvey, A. Heguy, et al., Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 179 (2009) 457-466.
119. A.L. Durham, A. McLaren, B.P. Hayes, et al., Regulation of Wnt4 in chronic obstructive pulmonary disease, FASEB J. 27 (2013) 2367-2381.
120. G.R. Van Pottelberge, P. Mestdagh, K.R. Bracke, et al., MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med. 183 (2011) 898-906.
121. P. Leidinger, A. Keller, A. Borries, et al., Specific peripheral miRNA profiles for distinguishing lung cancer from COPD, Lung Cancer 74 (2011) 41-47.
122. F. Akbas, E. Coskunpinar, E. Aynaci, et al., Analysis of serum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease, Exp. Lung Res. 38 (2012) 286-294.
123. W.M. Chatila, G.J. Criner, W.W. Hancock, et al., Blunted expression of miR-199a-5p in treg cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers, Clin. Exp. Immunol. 177 (2014) 341-352.