Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

PLoS Genetics

Volumn 10, Issue 5, 2014, Pages

  Wain, Louise V ^a   Sayers, Ian ^b   Soler Artigas, María ^a   Portelli, Michael A ^b   Zeggini, Eleftheria ^c   Obeidat, Ma'en ^d   Sin, Don D ^d   Bossé, Yohan ^e   Nickle, David ^f   Brandsma, Corry Anke ^g   Malarstig, Anders ^h   Vangjeli, Ciara ^h   Jelinsky, Scott A ⁱ   John, Sally ⁱ   Kilty, Iain ⁱ   McKeever, Tricia ^b   Shrine, Nick R G ^a   Cook, James P ^a   Patel, Shrina ^j   Spector, Tim D ^j   Hollox, Edward J ^a   Hall, Ian P ^b   Tobin, Martin D ^a,k   more..

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

^e LAVAL UNIVERSITY   (Canada)

^f MERCK RESEARCH LABORATORIES   (United States)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

ⁱ PFIZER INC   (United States)

^j KING'S COLLEGE LONDON   (United Kingdom)

^k Queen Mary University of London and Barts NIHR BRC NHS Trust National Institute for Health and Care Research   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TOBACCO SMOKE; CCDC38 PROTEIN, HUMAN; PROTEIN;

AIRWAY OBSTRUCTION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; EPITHELIUM CELL; EUKARYOTIC FLAGELLUM; EXOME; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE FUNCTION; GENE SEQUENCE; GENE STRUCTURE; HEREDITY; HUMAN; LUNG FUNCTION; MORBIDITY; MORTALITY; MUCOCILIARY CLEARANCE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; ADOLESCENT; ADULT; AGED; COHORT ANALYSIS; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CILIA; COHORT STUDIES; EXOME; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUANTITATIVE TRAIT LOCI; SMOKING; YOUNG ADULT;

EID: 84901625706     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004314     Document Type: Article

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