DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 5, 2014, Pages 912-922

  Vucic, Emily A ^a   Chari, Raj ^b   Thu, Kelsie L ^a   Wilson, Ian M ^a   Cotton, Allison M ^c   Kennett, Jennifer Y ^a   Zhang, May ^a   Lonergan, Kim M ^a   Steiling, Katrina ^d   Brown, Carolyn J ^c   McWilliams, Annette ^a   Ohtani, Keishi ^a   Lenburg, Marc E ^d   Sin, Don D ^e   Spira, Avrum ^d   MacAulay, Calum E ^a   Lam, Stephen ^a   Lam, Wan L ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^e The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

Author keywords

Chronic obstructive pulmonary disease; DNA methylation; Epigenetic regulation; Integrative omics; Small airways

Indexed keywords

DNA; RNA; TRANSCRIPTION FACTOR NRF2;

AGED; AIRWAY OBSTRUCTION; ARTICLE; BRONCHIOLE; BRONCHOSCOPY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; MALE; OXIDATION; PATHOGENESIS; RISK FACTOR; SMOKING; SMOKING CESSATION;

AGED; BRONCHI; DNA; DNA METHYLATION; EPITHELIUM; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NF-E2-RELATED FACTOR 2; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA; SMOKING;

EID: 84899717434     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0304OC     Document Type: Article

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