메뉴 건너뛰기




Volumn 459, Issue 1, 2014, Pages 193-203

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2

Author keywords

Dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2); Nuclear receptor; Phosphorylation; Pregnane X receptor (PXR); Ubiquitin protein ligase E3 component n recognin 5 (UBR5); Ubiquitination

Indexed keywords

DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2; PREGNANE X RECEPTOR; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 84896135872     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130558     Document Type: Article
Times cited : (36)

References (38)
  • 2
    • 0038000046 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor regulates xenobiotic detoxification
    • Kliewer, S. A. (2003) The nuclear pregnane X receptor regulates xenobiotic detoxification. J. Nutr. 133, 2444S-2447S
    • (2003) J. Nutr. , vol.133
    • Kliewer, S.A.1
  • 7
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • DOI 10.1038/87912
    • Synold, T. W., Dussault, I. and Forman, B. M. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 7, 584-590 (Pubitemid 32448326)
    • (2001) Nature Medicine , vol.7 , Issue.5 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 8
    • 37549060373 scopus 로고    scopus 로고
    • Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination
    • Jeong, H., Choi, S., Song, J. W., Chen, H. and Fischer, J. H. (2008) Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica 38, 62-75
    • (2008) Xenobiotica , vol.38 , pp. 62-75
    • Jeong, H.1    Choi, S.2    Song, J.W.3    Chen, H.4    Fischer, J.H.5
  • 9
    • 70349308415 scopus 로고    scopus 로고
    • A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein
    • Lichti-Kaiser, K., Brobst, D., Xu, C. and Staudinger, J. L. (2009) A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein. J. Pharmacol. Exp. Ther. 331, 65-76
    • (2009) J. Pharmacol. Exp. Ther. , vol.331 , pp. 65-76
    • Lichti-Kaiser, K.1    Brobst, D.2    Xu, C.3    Staudinger, J.L.4
  • 10
    • 84872703808 scopus 로고    scopus 로고
    • RBCK1, an E3 ubiquitin lLigase, interacts with and ubiquinates the human pregnane X receptor (hPXR)
    • Rana, R., Coulter, S., Kinyamu, H. and Goldstein, J. A. (2012) RBCK1, an E3 ubiquitin lLigase, interacts with and ubiquinates the human pregnane X receptor (hPXR). Drug Metab. Dispos. 41, 398-405
    • (2012) Drug Metab. Dispos. , vol.41 , pp. 398-405
    • Rana, R.1    Coulter, S.2    Kinyamu, H.3    Goldstein, J.A.4
  • 11
    • 79957729535 scopus 로고    scopus 로고
    • Post-translational modification of pregnane X receptor
    • Staudinger, J. L., Xu, C., Biswas, A. and Mani, S. (2011) Post-translational modification of pregnane X receptor. Pharmacol. Res. 64, 4-10
    • (2011) Pharmacol. Res. , vol.64 , pp. 4-10
    • Staudinger, J.L.1    Xu, C.2    Biswas, A.3    Mani, S.4
  • 12
    • 68149150791 scopus 로고    scopus 로고
    • Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression
    • Pondugula, S. R., Dong, H. and Chen, T. (2009) Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert Opin. Drug Metab. Toxicol. 5, 861-873
    • (2009) Expert Opin. Drug Metab. Toxicol. , vol.5 , pp. 861-873
    • Pondugula, S.R.1    Dong, H.2    Chen, T.3
  • 13
    • 63849272898 scopus 로고    scopus 로고
    • A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor
    • Pondugula, S. R., Brimer-Cline, C., Wu, J., Schuetz, E. G., Tyagi, R. K. and Chen, T. (2009) A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metab. Dispos. 37, 719-730
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 719-730
    • Pondugula, S.R.1    Brimer-Cline, C.2    Wu, J.3    Schuetz, E.G.4    Tyagi, R.K.5    Chen, T.6
  • 14
    • 84866465020 scopus 로고    scopus 로고
    • Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein
    • Sugatani, J., Uchida, T., Kurosawa, M., Yamaguchi, M., Yamazaki, Y., Ikari, A. and Miwa, M. (2012) Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein. Drug Metab. Dispos. 40, 2031-2040
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 2031-2040
    • Sugatani, J.1    Uchida, T.2    Kurosawa, M.3    Yamaguchi, M.4    Yamazaki, Y.5    Ikari, A.6    Miwa, M.7
  • 15
    • 33748991453 scopus 로고    scopus 로고
    • Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
    • DOI 10.1038/nrc1994, PII NRC1994
    • Hoeller, D., Hecker, C. M. and Dikic, I. (2006) Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat. Rev. Cancer 6, 776-788 (Pubitemid 44450466)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.10 , pp. 776-788
    • Hoeller, D.1    Hecker, C.-M.2    Dikic, I.3
  • 16
    • 0035857453 scopus 로고    scopus 로고
    • The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse
    • DOI 10.1016/S0303-7207(00)00395-6, PII S0303720700003956
    • Masuyama, H., Hiramatsu, Y., Mizutani, Y., Inoshita, H. and Kudo, T. (2001) The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. Mol. Cell. Endocrinol. 172, 47-56 (Pubitemid 32098399)
    • (2001) Molecular and Cellular Endocrinology , vol.172 , Issue.1-2 , pp. 47-56
    • Masuyama, H.1    Hiramatsu, Y.2    Mizutani, Y.3    Inoshita, H.4    Kudo, T.5
  • 17
    • 0036144190 scopus 로고    scopus 로고
    • Ligands have various potential effects on the degradation of pregnane X receptor by proteasome
    • DOI 10.1210/en.143.1.55
    • Masuyama, H., Inoshita, H., Hiramatsu, Y. and Kudo, T. (2002) Ligands have various potential effects on the degradation of pregnane X receptor by proteasome. Endocrinology 143, 55-61 (Pubitemid 34056403)
    • (2002) Endocrinology , vol.143 , Issue.1 , pp. 55-61
    • Masuyama, H.1    Inoshita, H.2    Hiramatsu, Y.3    Kudo, T.4
  • 18
    • 33646559053 scopus 로고    scopus 로고
    • A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
    • DOI 10.1038/nature04631, PII N04631
    • Gwack, Y., Sharma, S., Nardone, J., Tanasa, B., Iuga, A., Srikanth, S., Okamura, H., Bolton, D., Feske, S., Hogan, P. G. and Rao, A. (2006) A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441, 646-650 (Pubitemid 43927297)
    • (2006) Nature , vol.441 , Issue.7093 , pp. 646-650
    • Gwack, Y.1    Sharma, S.2    Nardone, J.3    Tanasa, B.4    Iuga, A.5    Srikanth, S.6    Okamura, H.7    Bolton, D.8    Feske, S.9    Hogan, P.G.10    Rao, A.11
  • 19
    • 57649198455 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells
    • Lin, W., Wu, J., Dong, H., Bouck, D., Zeng, F. Y. and Chen, T. (2008) Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J. Biol. Chem. 283, 30650-30657
    • (2008) J. Biol. Chem. , vol.283 , pp. 30650-30657
    • Lin, W.1    Wu, J.2    Dong, H.3    Bouck, D.4    Zeng, F.Y.5    Chen, T.6
  • 20
    • 84882783084 scopus 로고    scopus 로고
    • Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1
    • Wang, Y. M., Lin, W., Chai, S. C., Wu, J., Ong, S. S., Schuetz, E. G. and Chen, T. (2013) Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicol. Appl. Pharmacol. 272, 96-107
    • (2013) Toxicol. Appl. Pharmacol. , vol.272 , pp. 96-107
    • Wang, Y.M.1    Lin, W.2    Chai, S.C.3    Wu, J.4    Ong, S.S.5    Schuetz, E.G.6    Chen, T.7
  • 21
    • 84869860890 scopus 로고    scopus 로고
    • GUItars: A GUI tool for analysis of high-throughput RNA interference screening data
    • Goktug, A. N., Ong, S. S. and Chen, T. (2012) GUItars: a GUI tool for analysis of high-throughput RNA interference screening data. PLoS One 7, e49386
    • (2012) PLoS One , vol.7
    • Goktug, A.N.1    Ong, S.S.2    Chen, T.3
  • 22
    • 79960924226 scopus 로고    scopus 로고
    • Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens
    • Zhang, X. D. (2011) Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens. J. Biomol. Screen 16, 775-785
    • (2011) J. Biomol. Screen , vol.16 , pp. 775-785
    • Zhang, X.D.1
  • 23
    • 34547809341 scopus 로고    scopus 로고
    • A new method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays
    • Zhang, X. D. (2007) A new method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays. J. Biomol. Screen 12, 645-655
    • (2007) J. Biomol. Screen , vol.12 , pp. 645-655
    • Zhang, X.D.1
  • 25
    • 0033434080 scopus 로고    scopus 로고
    • Probability-based protein identification by searching sequence databases using mass spectrometry data
    • Perkins, D. N., Pappin, D. J., Creasy, D. M. and Cottrell, J. S. (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20, 3551-3567 (Pubitemid 30007252)
    • (1999) Electrophoresis , vol.20 , Issue.18 , pp. 3551-3567
    • Perkins, D.N.1    Pappin, D.J.C.2    Creasy, D.M.3    Cottrell, J.S.4
  • 26
    • 77953503612 scopus 로고    scopus 로고
    • Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells
    • Dong, H., Lin, W., Wu, J. and Chen, T. (2010) Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. BMC Biochem. 11, 23
    • (2010) BMC Biochem. , vol.11 , pp. 23
    • Dong, H.1    Lin, W.2    Wu, J.3    Chen, T.4
  • 27
    • 73149115997 scopus 로고    scopus 로고
    • Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell cycle-dependent expression
    • Sugatani, J., Osabe, M., Kurosawa, M., Kitamura, N., Ikari, A. and Miwa, M. (2010) Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression. Drug Metab. Dispos. 38, 177-186
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 177-186
    • Sugatani, J.1    Osabe, M.2    Kurosawa, M.3    Kitamura, N.4    Ikari, A.5    Miwa, M.6
  • 28
    • 64049091261 scopus 로고    scopus 로고
    • Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
    • Maddika, S. and Chen, J. (2009) Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat. Cell Biol. 11, 409-419
    • (2009) Nat. Cell Biol. , vol.11 , pp. 409-419
    • Maddika, S.1    Chen, J.2
  • 29
    • 33751112293 scopus 로고    scopus 로고
    • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases
    • DOI 10.1101/gad.1483206
    • He, Y. J., McCall, C. M., Hu, J., Zeng, Y. and Xiong, Y. (2006) DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 20, 2949-2954 (Pubitemid 44771729)
    • (2006) Genes and Development , vol.20 , Issue.21 , pp. 2949-2954
    • He, Y.J.1    McCall, C.M.2    Hu, J.3    Zeng, Y.4    Xiong, Y.5
  • 30
    • 30044438390 scopus 로고    scopus 로고
    • Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT)
    • DOI 10.1124/mol.105.013375
    • Johnson, D. R., Li, C. W., Chen, L. Y., Ghosh, J. C. and Chen, J. D. (2006) Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol. Pharmacol. 69, 99-108 (Pubitemid 43048897)
    • (2006) Molecular Pharmacology , vol.69 , Issue.1 , pp. 99-108
    • Johnson, D.R.1    Li, C.-W.2    Chen, L.-Y.3    Ghosh, J.C.4    Chen, J.D.5
  • 34
    • 0037005887 scopus 로고    scopus 로고
    • Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases
    • DOI 10.1016/S0014-5793(01)03221-5, PII S0014579301032215
    • Campbell, L. E. and Proud, C. G. (2002) Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett. 510, 31-36 (Pubitemid 34084879)
    • (2002) FEBS Letters , vol.510 , Issue.1-2 , pp. 31-36
    • Campbell, L.E.1    Proud, C.G.2
  • 37
    • 12844276658 scopus 로고    scopus 로고
    • Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization
    • DOI 10.1002/gcc.20136
    • Gorringe, K. L., Boussioutas, A. and Bowtell, D. D. (2005) Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes Chromosomes Cancer 42, 247-259 (Pubitemid 40171189)
    • (2005) Genes Chromosomes and Cancer , vol.42 , Issue.3 , pp. 247-259
    • Gorringe, K.L.1    Boussioutas, A.2    Bowtell, D.D.L.3
  • 38
    • 0041672360 scopus 로고    scopus 로고
    • Amplification and overexpression of the dual-specificity tyrosine-(Y)phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas
    • Miller, C. T., Aggarwal, S., Lin, T. K., Dagenais, S. L., Contreras, J. I., Orringer, M. B., Glover, T. W., Beer, D. G. and Lin, L. (2003) Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. Cancer Res. 63, 4136-4143 (Pubitemid 36917938)
    • (2003) Cancer Research , vol.63 , Issue.14 , pp. 4136-4143
    • Miller, C.T.1    Aggarwal, S.2    Lin, T.K.3    Dagenais, S.L.4    Contreras, J.I.5    Orringer, M.B.6    Glover, T.W.7    Beer, D.G.8    Lin, L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.