The potential and advances in RNAi therapy: Chemical and structural modifications of siRNA molecules and use of biocompatible nanocarriers

Journal of Controlled Release

Volumn 193, Issue , 2014, Pages 113-121

  Joo, Min Kyung ^a   Yhee, Ji Young ^a   Kim, Sun Hwa ^a   Kim, Kwangmeyung ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

Chemical and structural modifications; Gene delivery; Polymerized siRNA; RNA interference

Indexed keywords

GENE DELIVERY; NANO-CARRIERS; POLYMERIZED SIRNA; RNA INTERFERENCE; STRUCTURAL MODIFICATIONS;

GELATIN NANOPARTICLE; GLYCOL CHITOSAN NANOPARTICLE; NANOCARRIER; NANOPARTICLE; NUCLEASE; SERUM ALBUMIN NANOPARTICLE; SMALL INTERFERING RNA; TRANSFERRIN NANOPARTICLE; UNCLASSIFIED DRUG; BIOMATERIAL; DRUG CARRIER;

ARTICLE; BIOCOMPATIBILITY; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CROSS LINKING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN CLEAVAGE; RNA INTERFERENCE; ANIMAL; BLOOD; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; FLUORESCENCE MICROSCOPY; GENE THERAPY; GENETICS; NEOPLASMS; SURFACE PROPERTY; TUMOR CELL LINE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DESIGN; DRUG STABILITY; GENETIC THERAPY; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; NANOPARTICLES; NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURFACE PROPERTIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84908300697     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.05.030     Document Type: Article

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