메뉴 건너뛰기




Volumn 6, Issue 9, 2014, Pages 973-988

Overcoming tumor-mediated immunosuppression

Author keywords

cancer; checkpoint inhibitors; CTLA 4; immune escape; immunotherapy; PD 1; PD L1; tumor mediated immunosuppression

Indexed keywords

CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TUMOR ANTIGEN;

EID: 84908123906     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.58     Document Type: Review
Times cited : (39)

References (169)
  • 2
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331(6024), 1565-1570 (2011
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 3
    • 84870352830 scopus 로고    scopus 로고
    • Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma
    • Wang QJ, Hanada K, Robbins PF, Li YF, Yang JC. Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma. Cancer Res. 72(23), 6119-6129 (2012
    • (2012) Cancer Res , vol.72 , Issue.23 , pp. 6119-6129
    • Wang, Q.J.1    Hanada, K.2    Robbins, P.F.3    Li, Y.F.4    Yang, J.C.5
  • 4
    • 84877072174 scopus 로고    scopus 로고
    • Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
    • Gajewski TF, Woo SR, Zha Y et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr. Opin. Immunol. 25(2), 268-276 (2013
    • (2013) Curr. Opin. Immunol , vol.25 , Issue.2 , pp. 268-276
    • Gajewski, T.F.1    Woo, S.R.2    Zha, Y.3
  • 5
    • 33947214949 scopus 로고    scopus 로고
    • Immunotherapeutic strategies for high-risk bladder cancer
    • Sharma P, Old LJ, Allison JP. Immunotherapeutic strategies for high-risk bladder cancer. Semin. Oncol. 34(2), 165-172 (2007
    • (2007) Semin. Oncol , vol.34 , Issue.2 , pp. 165-172
    • Sharma, P.1    Old, L.J.2    Allison, J.P.3
  • 7
    • 66849083515 scopus 로고    scopus 로고
    • Biomarkers of therapeutic response in melanoma and renal cell carcinoma: Potential inroads to improved immunotherapy
    • Kirkwood JM, Tarhini AA. Biomarkers of therapeutic response in melanoma and renal cell carcinoma: potential inroads to improved immunotherapy. J. Clin. Oncol. 27(16), 2583-2585 (2009
    • (2009) J. Clin. Oncol , vol.27 , Issue.16 , pp. 2583-2585
    • Kirkwood, J.M.1    Tarhini, A.A.2
  • 8
    • 84880278490 scopus 로고    scopus 로고
    • High-dose interleukin-2: Is it still indicated for melanoma and RCC in an era of targeted therapies?
    • Amin A, White RL Jr High-dose interleukin-2: is it still indicated for melanoma and RCC in an era of targeted therapies?. Oncology 27(7), 680-691 (2013
    • (2013) Oncology , vol.27 , Issue.7 , pp. 680-691
    • Amin, A.1    White, R.L.2
  • 9
    • 66849095271 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    • Sabatino M, Kim-Schulze S, Panelli MC et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J. Clin. Oncol. 27(16), 2645-2652 (2009
    • (2009) J. Clin. Oncol , vol.27 , Issue.16 , pp. 2645-2652
    • Sabatino, M.1    Kim-Schulze, S.2    Panelli, M.C.3
  • 10
    • 33646103420 scopus 로고    scopus 로고
    • Interleukin-2 for the treatment of solid tumors other than melanoma and renal cell carcinoma
    • Grande C, Firvida JL, Navas V, Casal J. Interleukin-2 for the treatment of solid tumors other than melanoma and renal cell carcinoma. Anticancer Drugs 17(1), 1-12 (2006
    • (2006) Anticancer Drugs , vol.17 , Issue.1 , pp. 1-12
    • Grande, C.1    Firvida, J.L.2    Navas, V.3    Casal, J.4
  • 11
    • 79955451697 scopus 로고    scopus 로고
    • Dendritic cell based tumor vaccination in prostate and renal cell cancer: A systematic review and meta-analysis
    • Draube A, Klein-Gonzalez N, Mattheus S et al. Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis. PLoS ONE 6(4), e18801 (2011
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18801
    • Draube, A.1    Klein-Gonzalez, N.2    Mattheus, S.3
  • 12
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363(5), 411-422 (2010
    • (2010) N. Engl. J. Med , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 13
    • 80053064081 scopus 로고    scopus 로고
    • Immunotherapy for prostate cancer: Biology and therapeutic approaches
    • Cha E, Fong L. Immunotherapy for prostate cancer: biology and therapeutic approaches. J. Clin. Oncol. 29(27), 3677-3685 (2011
    • (2011) J. Clin. Oncol , vol.29 , Issue.27 , pp. 3677-3685
    • Cha, E.1    Fong, L.2
  • 14
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, Phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • Higano CS, Schellhammer PF, Small EJ et al. Integrated data from 2 randomized, double-blind, placebo-controlled, Phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 115(16), 3670-3679 (2009
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 15
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled Phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • Small EJ, Schellhammer PF, Higano CS et al. Placebo-controlled Phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J. Clin. Oncol. 24(19), 3089-3094 (2006
    • (2006) J. Clin. Oncol , vol.24 , Issue.19 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3
  • 16
    • 84890147150 scopus 로고    scopus 로고
    • Exploiting the curative potential of adoptive T-cell therapy for cancer
    • Hinrichs CS, Rosenberg SA. Exploiting the curative potential of adoptive T-cell therapy for cancer. Immunol. Rev. 257(1), 56-71 (2014
    • (2014) Immunol. Rev , vol.257 , Issue.1 , pp. 56-71
    • Hinrichs, C.S.1    Rosenberg, S.A.2
  • 17
    • 34548587281 scopus 로고    scopus 로고
    • GMP production of anti-tumor cytotoxic T-cell lines for adoptive T-cell therapy in patients with solid neoplasia
    • Turin I, Pedrazzoli P, Tullio C et al. GMP production of anti-tumor cytotoxic T-cell lines for adoptive T-cell therapy in patients with solid neoplasia. Cytotherapy 9(5), 499-507 (2007
    • (2007) Cytotherapy , vol.9 , Issue.5 , pp. 499-507
    • Turin, I.1    Pedrazzoli, P.2    Tullio, C.3
  • 18
    • 33846912750 scopus 로고    scopus 로고
    • Phase I/II feasibility study evaluating the generation of leukemia-reactive cytotoxic T lymphocyte lines for treatment of patients with relapsed leukemia after allogeneic stem cell transplantation
    • Marijt E, Wafelman A, Van Der Hoorn M et al. Phase I/II feasibility study evaluating the generation of leukemia-reactive cytotoxic T lymphocyte lines for treatment of patients with relapsed leukemia after allogeneic stem cell transplantation. Haematologica 92(1), 72-80 (2007
    • (2007) Haematologica , vol.92 , Issue.1 , pp. 72-80
    • Marijt, E.1    Wafelman, A.2    Van Der Hoorn, M.3
  • 19
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer Res. 17(13), 4550-4557 (2011
    • (2011) Clin. Cancer Res , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 20
    • 33750940238 scopus 로고    scopus 로고
    • Phase i study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma
    • Mackensen A, Meidenbauer N, Vogl S, Laumer M, Berger J, Andreesen R. Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma. J. Clin. Oncol. 24(31), 5060-5069 (2006
    • (2006) J. Clin. Oncol , vol.24 , Issue.31 , pp. 5060-5069
    • MacKensen, A.1    Meidenbauer, N.2    Vogl, S.3    Laumer, M.4    Berger, J.5    Andreesen, R.6
  • 21
    • 0036281441 scopus 로고    scopus 로고
    • Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: A randomized trial
    • Kono K, Takahashi A, Ichihara F et al. Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial. Clin. Cancer Res. 8(6), 1767-1771 (2002
    • (2002) Clin. Cancer Res , vol.8 , Issue.6 , pp. 1767-1771
    • Kono, K.1    Takahashi, A.2    Ichihara, F.3
  • 22
    • 84877638694 scopus 로고    scopus 로고
    • Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy
    • Ma C, Cheung AF, Chodon T et al. Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer Discov. 3(4), 418-429 (2013
    • (2013) Cancer Discov , vol.3 , Issue.4 , pp. 418-429
    • Ma, C.1    Cheung, A.F.2    Chodon, T.3
  • 23
    • 36348942363 scopus 로고    scopus 로고
    • Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer
    • Bernhard H, Neudorfer J, Gebhard K et al. Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer. Cancer Immunol. Immunother. 57(2), 271-280 (2008
    • (2008) Cancer Immunol. Immunother , vol.57 , Issue.2 , pp. 271-280
    • Bernhard, H.1    Neudorfer, J.2    Gebhard, K.3
  • 24
    • 33644788176 scopus 로고    scopus 로고
    • Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    • Comoli P, Pedrazzoli P, Maccario R et al. Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes. J. Clin. Oncol. 23(35), 8942-8949 (2005
    • (2005) J. Clin. Oncol , vol.23 , Issue.35 , pp. 8942-8949
    • Comoli, P.1    Pedrazzoli, P.2    MacCario, R.3
  • 25
    • 84890180201 scopus 로고    scopus 로고
    • Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells
    • Jensen MC, Riddell SR. Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells. Immunol. Rev. 257(1), 127-144 (2014
    • (2014) Immunol. Rev , vol.257 , Issue.1 , pp. 127-144
    • Jensen, M.C.1    Riddell, S.R.2
  • 26
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till BG, Jensen MC, Wang J et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112(6), 2261-2271 (2008
    • (2008) Blood , vol.112 , Issue.6 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3
  • 27
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    • Kochenderfer JN, Wilson WH, Janik JE et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116(20), 4099-4102 (2010
    • (2010) Blood , vol.116 , Issue.20 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3
  • 28
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 118(18), 4817-4828 (2011
    • (2011) Blood , vol.118 , Issue.18 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3
  • 29
    • 80051720194 scopus 로고    scopus 로고
    • CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365(8), 725-733 (2011
    • (2011) June , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4
  • 30
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368(16), 1509-1518 (2013
    • (2013) N. Engl. J. Med , vol.368 , Issue.16 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 31
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific T-cell engaging antibodies for cancer therapy
    • Baeuerle PA, Reinhardt C. Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res. 69(12), 4941-4944 (2009
    • (2009) Cancer Res , vol.69 , Issue.12 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 32
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321(5891), 974-977 (2008
    • (2008) Science , vol.321 , Issue.5891 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3
  • 33
    • 0037851832 scopus 로고    scopus 로고
    • Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
    • Loffler A, Gruen M, Wuchter C et al. Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Leukemia 17(5), 900-909 (2003
    • (2003) Leukemia , vol.17 , Issue.5 , pp. 900-909
    • Loffler, A.1    Gruen, M.2    Wuchter, C.3
  • 34
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp MS, Kufer P, Gokbuget N et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 29(18), 2493-2498 (2011
    • (2011) J. Clin. Oncol , vol.29 , Issue.18 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3
  • 35
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
    • Aigner M, Feulner J, Schaffer S et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia 27(5), 1107-1115 (2013
    • (2013) Leukemia , vol.27 , Issue.5 , pp. 1107-1115
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3
  • 36
    • 84894422104 scopus 로고    scopus 로고
    • An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression
    • Zhang P, Shi B, Gao H et al. An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression. Cancer Immunol. Immunother. 63(2), 121-132 (2013
    • (2013) Cancer Immunol. Immunother , vol.63 , Issue.2 , pp. 121-132
    • Zhang, P.1    Shi, B.2    Gao, H.3
  • 37
    • 84863132749 scopus 로고    scopus 로고
    • New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody for tumor targeting
    • Groth A, Salnikov AV, Ottinger S et al. New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody for tumor targeting. Clin. Cancer Res. 18(4), 1028-1038 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.4 , pp. 1028-1038
    • Groth, A.1    Salnikov, A.V.2    Ottinger, S.3
  • 38
    • 77955433583 scopus 로고    scopus 로고
    • T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS-and BRAF-mutated colorectal cancer cells
    • Lutterbuese R, Raum T, Kischel R et al. T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS-and BRAF-mutated colorectal cancer cells. Proc. Natl Acad. Sci. USA 107(28), 12605-12610 (2010
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.28 , pp. 12605-12610
    • Lutterbuese, R.1    Raum, T.2    Kischel, R.3
  • 39
    • 74249122446 scopus 로고    scopus 로고
    • Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody
    • Osada T, Hsu D, Hammond S et al. Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody. Br. J. Cancer 102(1), 124-133 (2010
    • (2010) Br. J. Cancer , vol.102 , Issue.1 , pp. 124-133
    • Osada, T.1    Hsu, D.2    Hammond, S.3
  • 40
    • 84862507314 scopus 로고    scopus 로고
    • A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells
    • Yamamoto K, Trad A, Baumgart A et al. A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells. Biochem. J. 445(1), 135-144 (2012
    • (2012) Biochem. J. , vol.445 , Issue.1 , pp. 135-144
    • Yamamoto, K.1    Trad, A.2    Baumgart, A.3
  • 41
    • 79952380566 scopus 로고    scopus 로고
    • Effective targeting of prostate cancer by lymphocytes redirected by a PSMA ' CD3 bispecific single-chain diabody
    • Fortmuller K, Alt K, Gierschner D et al. Effective targeting of prostate cancer by lymphocytes redirected by a PSMA ' CD3 bispecific single-chain diabody. Prostate 71(6), 588-596 (2011
    • (2011) Prostate , vol.71 , Issue.6 , pp. 588-596
    • Fortmuller, K.1    Alt, K.2    Gierschner, D.3
  • 42
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795), 1960-1964 (2006
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 43
    • 0035872423 scopus 로고    scopus 로고
    • Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas
    • Schumacher K, Haensch W, Roefzaad C, Schlag PM. Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res. 61(10), 3932-3936 (2001
    • (2001) Cancer Res , vol.61 , Issue.10 , pp. 3932-3936
    • Schumacher, K.1    Haensch, W.2    Roefzaad, C.3    Schlag, P.M.4
  • 44
    • 1842505346 scopus 로고    scopus 로고
    • CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma
    • Fukunaga A, Miyamoto M, Cho Y et al. CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas 28(1), e26-e31 (2004
    • (2004) Pancreas , vol.28 , Issue.1 , pp. e26-e31
    • Fukunaga, A.1    Miyamoto, M.2    Cho, Y.3
  • 45
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, Olson SH, Ahn J et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc. Natl Acad. Sci. USA 102(51), 18538-18543 (2005
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.51 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3
  • 46
    • 55949118778 scopus 로고    scopus 로고
    • Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer
    • Lee HE, Chae SW, Lee YJ et al. Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer. Br. J. Cancer 99(10), 1704-1711 (2008
    • (2008) Br. J. Cancer , vol.99 , Issue.10 , pp. 1704-1711
    • Lee, H.E.1    Chae, S.W.2    Lee, Y.J.3
  • 47
    • 84871582535 scopus 로고    scopus 로고
    • Impact of CD68/(CD3+CD20) ratio at the invasive front of primary tumors on distant metastasis development in breast cancer
    • Eiro N, Pidal I, Fernandez-Garcia B et al. Impact of CD68/(CD3+CD20) ratio at the invasive front of primary tumors on distant metastasis development in breast cancer. PLoS ONE 7(12), e52796 (2012
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. e52796
    • Eiro, N.1    Pidal, I.2    Fernandez-Garcia, B.3
  • 48
    • 84878928835 scopus 로고    scopus 로고
    • Intratumoral FOXP3(+VEGFR2(+regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer vol 146, pg 26, 2013)
    • Suzuki H, Onishi H, Morisaki T, Tanaka M, Katano M. Intratumoral FOXP3(+)VEGFR2(+) regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer (vol 146, pg 26, 2013). Clin. Immunol. 148(1), 148-148 (2013
    • (2013) Clin. Immunol. , vol.148 , Issue.1 , pp. 148-148
    • Suzuki, H.1    Onishi, H.2    Morisaki, T.3    Tanaka, M.4    Katano, M.5
  • 49
    • 77950468866 scopus 로고    scopus 로고
    • Intratumoral CD8(+) T/FOXP3(+) cell ratio is a predictive marker for survival in patients with colorectal cancer
    • Suzuki H, Chikazawa N, Tasaka T et al. Intratumoral CD8(+) T/FOXP3(+) cell ratio is a predictive marker for survival in patients with colorectal cancer. Cancer Immunol. Immun. 59(5), 653-661 (2010
    • (2010) Cancer Immunol. Immun , vol.59 , Issue.5 , pp. 653-661
    • Suzuki, H.1    Chikazawa, N.2    Tasaka, T.3
  • 50
    • 84862135169 scopus 로고    scopus 로고
    • What are regulatory T cells (Treg) regulating in cancer and why?. Semin
    • Whiteside TL. What are regulatory T cells (Treg) regulating in cancer and why?. Semin. Cancer Biol. 22(4), 327-334 (2012
    • (2012) Cancer Biol , vol.22 , Issue.4 , pp. 327-334
    • Whiteside, T.L.1
  • 51
  • 53
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
    • Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J. Exp. Med. 210(11), 2435-2466 (2013
    • (2013) J. Exp. Med , vol.210 , Issue.11 , pp. 2435-2466
    • Bos, P.D.1    Plitas, G.2    Rudra, D.3    Lee, S.Y.4    Rudensky, A.Y.5
  • 54
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K, Mayer CT, Lahl K et al. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 70(20), 7788-7799 (2010
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3
  • 55
    • 78649557780 scopus 로고    scopus 로고
    • Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
    • Li X, Kostareli E, Suffner J, Garbi N, Hammerling GJ. Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Eur. J. Immunol. 40(12), 3325-3335 (2010
    • (2010) Eur. J. Immunol , vol.40 , Issue.12 , pp. 3325-3335
    • Li, X.1    Kostareli, E.2    Suffner, J.3    Garbi, N.4    Hammerling, G.J.5
  • 56
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng MW, Ngiow SF, Von Scheidt B, McLaughlin N, Sparwasser T, Smyth MJ. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res. 70(20), 7800-7809 (2010
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    Von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6
  • 57
    • 64549145119 scopus 로고    scopus 로고
    • Targeting of CD4+CD25high cells while preserving CD4+CD25low cells with low-dose chimeric anti-CD25 antibody in adoptive immunotherapy of cancer
    • Okita R, Yamaguchi Y, Ohara M et al. Targeting of CD4+CD25high cells while preserving CD4+CD25low cells with low-dose chimeric anti-CD25 antibody in adoptive immunotherapy of cancer. Int. J. Oncol. 34(2), 563-572 (2009
    • (2009) Int. J. Oncol , vol.34 , Issue.2 , pp. 563-572
    • Okita, R.1    Yamaguchi, Y.2    Ohara, M.3
  • 58
    • 77950638599 scopus 로고    scopus 로고
    • Impact of basiliximab on regulatory T-cells early after kidney transplantation: Down-regulation of CD25 by receptor modulation
    • Vondran FW, Timrott K, Tross J et al. Impact of basiliximab on regulatory T-cells early after kidney transplantation: down-regulation of CD25 by receptor modulation. Transpl. Int. 23(5), 514-523 (2010
    • (2010) Transpl. Int , vol.23 , Issue.5 , pp. 514-523
    • Vondran, F.W.1    Timrott, K.2    Tross, J.3
  • 59
    • 84861175955 scopus 로고    scopus 로고
    • CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
    • Rech AJ, Mick R, Martin S et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci. Transl. Med. 4(134), 134ra162 (2012
    • (2012) Sci. Transl. Med , vol.4 , Issue.134 , pp. 134ra162
    • Rech, A.J.1    Mick, R.2    Martin, S.3
  • 60
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse MA, Hobeika AC, Osada T et al. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood 112(3), 610-618 (2008
    • (2008) Blood , vol.112 , Issue.3 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3
  • 61
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J, Su Z, Rizzieri D et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J. Clin. Invest. 115(12), 3623-3633 (2005
    • (2005) J. Clin. Invest , vol.115 , Issue.12 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3
  • 62
    • 77958056009 scopus 로고    scopus 로고
    • Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: A Phase I/II study in metastatic melanoma patients
    • Jacobs JF, Punt CJ, Lesterhuis WJ et al. Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a Phase I/II study in metastatic melanoma patients. Clin. Cancer Res. 16(20), 5067-5078 (2010
    • (2010) Clin. Cancer Res , vol.16 , Issue.20 , pp. 5067-5078
    • Jacobs, J.F.1    Punt, C.J.2    Lesterhuis, W.J.3
  • 63
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N, Magnani CF, Huber S et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat. Med. 19(6), 739-746 (2013
    • (2013) Nat. Med , vol.19 , Issue.6 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3
  • 65
    • 67449128008 scopus 로고    scopus 로고
    • Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression
    • Mandapathil M, Lang S, Gorelik E, Whiteside TL. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J. Immunol. Methods 346(1-2), 55-63 (2009
    • (2009) J. Immunol. Methods , vol.346 , Issue.1-2 , pp. 55-63
    • Mandapathil, M.1    Lang, S.2    Gorelik, E.3    Whiteside, T.L.4
  • 66
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • Croft M. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu. Rev. Immunol. 28, 57-78 (2010
    • (2010) Annu. Rev. Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 68
    • 0034651736 scopus 로고    scopus 로고
    • Engagement of the OX-40 receptor in vivo enhances antitumor immunity
    • Weinberg AD, Rivera MM, Prell R et al. Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J. Immunol. 164(4), 2160-2169 (2000
    • (2000) J. Immunol , vol.164 , Issue.4 , pp. 2160-2169
    • Weinberg, A.D.1    Rivera, M.M.2    Prell, R.3
  • 69
    • 78549292810 scopus 로고    scopus 로고
    • A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment
    • Pardee AD, McCurry D, Alber S, Hu P, Epstein AL, Storkus WJ. A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment. Cancer Res. 70(22), 9041-9052 (2010
    • (2010) Cancer Res , vol.70 , Issue.22 , pp. 9041-9052
    • Pardee, A.D.1    McCurry, D.2    Alber, S.3    Hu, P.4    Epstein, A.L.5    Storkus, W.J.6
  • 70
    • 84891275907 scopus 로고    scopus 로고
    • OX40 is a potent immune-stimulating target in late-stage cancer patients
    • Curti BD, Kovacsovics-Bankowski M, Morris N et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 73(24), 7189-7198 (2013
    • (2013) Cancer Res , vol.73 , Issue.24 , pp. 7189-7198
    • Curti, B.D.1    Kovacsovics-Bankowski, M.2    Morris, N.3
  • 71
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3(6), 682-685 (1997
    • (1997) Nat. Med , vol.3 , Issue.6 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 73
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens GL, McHugh RS, Whitters MJ et al. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J. Immunol. 173(8), 5008-5020 (2004
    • (2004) J. Immunol , vol.173 , Issue.8 , pp. 5008-5020
    • Stephens, G.L.1    McHugh, R.S.2    Whitters, M.J.3
  • 74
    • 84877059530 scopus 로고    scopus 로고
    • The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
    • Moran AE, Kovacsovics-Bankowski M, Weinberg AD. The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr. Opin. Immunol. 25(2), 230-237 (2013
    • (2013) Curr. Opin. Immunol , vol.25 , Issue.2 , pp. 230-237
    • Moran, A.E.1    Kovacsovics-Bankowski, M.2    Weinberg, A.D.3
  • 76
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364(26), 2517-2526 (2011
    • (2011) N. Engl. J. Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 77
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010
    • (2010) N. Engl. J. Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 78
    • 82255192901 scopus 로고    scopus 로고
    • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    • Walker LS, Sansom DM. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat. Rev. Immunol. 11(12), 852-863 (2011
    • (2011) Nat. Rev. Immunol , vol.11 , Issue.12 , pp. 852-863
    • Walker, L.S.1    Sansom, D.M.2
  • 79
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J. Clin. Invest. 116(7), 1935-1945 (2006
    • (2006) J. Clin. Invest , vol.116 , Issue.7 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 80
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • Liakou CI, Kamat A, Tang DN et al. CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc. Natl Acad. Sci. USA 105(39), 14987-14992 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.39 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3
  • 81
    • 62449309334 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues
    • Chen H, Liakou CI, Kamat A et al. Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Proc. Natl Acad. Sci. USA 106(8), 2729-2734 (2009
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.8 , pp. 2729-2734
    • Chen, H.1    Liakou, C.I.2    Kamat, A.3
  • 82
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
    • Duraiswamy J, Kaluza KM, Freeman GJ, Coukos G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 73(12), 3591-3603 (2013
    • (2013) Cancer Res , vol.73 , Issue.12 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3    Coukos, G.4
  • 83
    • 84864123005 scopus 로고    scopus 로고
    • Cutting edge: Cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells
    • Wang CJ, Kenefeck R, Wardzinski L et al. Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells. J. Immunol. 189(3), 1118-1122 (2012
    • (2012) J. Immunol , vol.189 , Issue.3 , pp. 1118-1122
    • Wang, C.J.1    Kenefeck, R.2    Wardzinski, L.3
  • 84
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332(6029), 600-603 (2011
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 85
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J. Exp. Med. 210(9), 1695-1710 (2013
    • (2013) J. Exp. Med , vol.210 , Issue.9 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3
  • 86
    • 84868578365 scopus 로고    scopus 로고
    • Tumor-infiltrating gammadelta T lymphocytes predict clinical outcome in human breast cancer
    • Ma C, Zhang Q, Ye J et al. Tumor-infiltrating gammadelta T lymphocytes predict clinical outcome in human breast cancer. J. Immunol. 189(10), 5029-5036 (2012
    • (2012) J. Immunol , vol.189 , Issue.10 , pp. 5029-5036
    • Ma, C.1    Zhang, Q.2    Ye, J.3
  • 87
    • 33845726557 scopus 로고    scopus 로고
    • Increased frequency of CD4+ cells expressing CD161 in cancer patients
    • Iliopoulou EG, Karamouzis MV, Missitzis I et al. Increased frequency of CD4+ cells expressing CD161 in cancer patients. Clin. Cancer Res. 12(23), 6901-6909 (2006
    • (2006) Clin. Cancer Res , vol.12 , Issue.23 , pp. 6901-6909
    • Iliopoulou, E.G.1    Karamouzis, M.V.2    Missitzis, I.3
  • 88
    • 78149488860 scopus 로고    scopus 로고
    • CD20+ B cells: The other tumor-infiltrating lymphocytes
    • Nelson BH. CD20+ B cells: the other tumor-infiltrating lymphocytes. J. Immunol. 185(9), 4977-4982 (2010
    • (2010) J. Immunol , vol.185 , Issue.9 , pp. 4977-4982
    • Nelson, B.H.1
  • 89
    • 79955140403 scopus 로고    scopus 로고
    • Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia
    • Catellani S, Pierri I, Gobbi M, Poggi A, Zocchi MR. Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia. PLoS ONE 6(4), e18925 (2011
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18925
    • Catellani, S.1    Pierri, I.2    Gobbi, M.3    Poggi, A.4    Zocchi, M.R.5
  • 90
    • 33750626239 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation
    • Jahrsdorfer B, Blackwell SE, Wooldridge JE et al. B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood 108(8), 2712-2719 (2006
    • (2006) Blood , vol.108 , Issue.8 , pp. 2712-2719
    • Jahrsdorfer, B.1    Blackwell, S.E.2    Wooldridge, J.E.3
  • 91
    • 77951629658 scopus 로고    scopus 로고
    • B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: Therapeutic B cell depletion enhances B16 melanoma growth in mice
    • Dilillo DJ, Yanaba K, Tedder TF. B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. J. Immunol. 184(7), 4006-4016 (2010
    • (2010) J. Immunol , vol.184 , Issue.7 , pp. 4006-4016
    • Dilillo, D.J.1    Yanaba, K.2    Tedder, T.F.3
  • 92
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 117(2), 530-541 (2011
    • (2011) Blood , vol.117 , Issue.2 , pp. 530-541
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3
  • 93
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286), 302-305 (2010
    • (2010) Nature , vol.464 , Issue.7286 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 94
    • 84874720574 scopus 로고    scopus 로고
    • CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation
    • Flores-Borja F, Bosma A, Ng D et al. CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Sci. Transl. Med. 5(173), 173ra123 (2013
    • (2013) Sci. Transl. Med , vol.5 , Issue.173 , pp. 173ra123
    • Flores-Borja, F.1    Bosma, A.2    Ng, D.3
  • 95
    • 79956207159 scopus 로고    scopus 로고
    • B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma
    • Sorrentino R, Morello S, Forte G et al. B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma. Am. J. Respir. Crit. Care Med. 183(10), 1369-1379 (2011
    • (2011) Am. J. Respir. Crit. Care Med , vol.183 , Issue.10 , pp. 1369-1379
    • Sorrentino, R.1    Morello, S.2    Forte, G.3
  • 96
    • 79956131523 scopus 로고    scopus 로고
    • Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells
    • Olkhanud PB, Damdinsuren B, Bodogai M et al. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells. Cancer Res. 71(10), 3505-3515 (2011
    • (2011) Cancer Res , vol.71 , Issue.10 , pp. 3505-3515
    • Olkhanud, P.B.1    Damdinsuren, B.2    Bodogai, M.3
  • 97
    • 84862557227 scopus 로고    scopus 로고
    • CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer
    • Nielsen JS, Sahota RA, Milne K et al. CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer. Clin. Cancer Res. 18(12), 3281-3292 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.12 , pp. 3281-3292
    • Nielsen, J.S.1    Sahota, R.A.2    Milne, K.3
  • 99
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea G, Mlecnik B, Tosolini M et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39(4), 782-795 (2013
    • (2013) Immunity , vol.39 , Issue.4 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3
  • 100
    • 76349088502 scopus 로고    scopus 로고
    • FcRgamma activation regulates inflammation-associated squamous carcinogenesis
    • Andreu P, Johansson M, Affara NI et al. FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 17(2), 121-134 (2010
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 121-134
    • Andreu, P.1    Johansson, M.2    Affara, N.I.3
  • 101
    • 84860532352 scopus 로고    scopus 로고
    • A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors
    • Schmidt M, Hellwig B, Hammad S et al. A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors. Clin. Cancer Res. 18(9), 2695-2703 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.9 , pp. 2695-2703
    • Schmidt, M.1    Hellwig, B.2    Hammad, S.3
  • 102
    • 67650381830 scopus 로고    scopus 로고
    • Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers
    • Carpenter EL, Mick R, Rech AJ et al. Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers. Clin. Cancer Res. 15(13), 4277-4287 (2009
    • (2009) Clin. Cancer Res , vol.15 , Issue.13 , pp. 4277-4287
    • Carpenter, E.L.1    Mick, R.2    Rech, A.J.3
  • 103
    • 84878069933 scopus 로고    scopus 로고
    • Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies
    • Zirakzadeh AA, Marits P, Sherif A, Winqvist O. Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies. J. Immunol. 190(11), 5847-5855 (2013
    • (2013) J. Immunol , vol.190 , Issue.11 , pp. 5847-5855
    • Zirakzadeh, A.A.1    Marits, P.2    Sherif, A.3    Winqvist, O.4
  • 104
    • 84876991334 scopus 로고    scopus 로고
    • Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells
    • Lindner S, Dahlke K, Sontheimer K et al. Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res. 73(8), 2468-2479 (2013
    • (2013) Cancer Res , vol.73 , Issue.8 , pp. 2468-2479
    • Lindner, S.1    Dahlke, K.2    Sontheimer, K.3
  • 105
    • 84872559040 scopus 로고    scopus 로고
    • The immunosuppressive tumour network: Myeloid-derived suppressor cells, regulatory T cells and natural killer T cells
    • Lindau D, Gielen P, Kroesen M, Wesseling P, Adema GJ. The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology 138(2), 105-115 (2013
    • (2013) Immunology , vol.138 , Issue.2 , pp. 105-115
    • Lindau, D.1    Gielen, P.2    Kroesen, M.3    Wesseling, P.4    Adema, G.J.5
  • 106
    • 84880948301 scopus 로고    scopus 로고
    • Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer
    • Najjar YG, Finke JH. Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer. Front. Oncol. 3, 49 (2013
    • (2013) Front. Oncol , vol.3 , Issue.49
    • Najjar, Y.G.1    Finke, J.H.2
  • 107
    • 84888334918 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
    • Jordan KR, Amaria RN, Ramirez O et al. Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients. Cancer Immunol. Immunother. 62(11), 1711-1722 (2013
    • (2013) Cancer Immunol. Immunother , vol.62 , Issue.11 , pp. 1711-1722
    • Jordan, K.R.1    Amaria, R.N.2    Ramirez, O.3
  • 108
    • 84874236258 scopus 로고    scopus 로고
    • Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma
    • Zhang B, Wang Z, Wu L et al. Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma. PLoS ONE 8(2), e57114 (2013
    • (2013) PLoS ONE , vol.8 , Issue.2 , pp. e57114
    • Zhang, B.1    Wang, Z.2    Wu, L.3
  • 109
    • 84880924329 scopus 로고    scopus 로고
    • Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
    • Arihara F, Mizukoshi E, Kitahara M et al. Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. Cancer Immunol. Immunother. 62(8), 1421-1430 (2013
    • (2013) Cancer Immunol. Immunother , vol.62 , Issue.8 , pp. 1421-1430
    • Arihara, F.1    Mizukoshi, E.2    Kitahara, M.3
  • 110
    • 84861577263 scopus 로고    scopus 로고
    • The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment
    • Lee JM, Seo JH, Kim YJ, Kim YS, Ko HJ, Kang CY. The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment. Int. J. Cancer 131(3), 741-751 (2012
    • (2012) Int. J. Cancer , vol.131 , Issue.3 , pp. 741-751
    • Lee, J.M.1    Seo, J.H.2    Kim, Y.J.3    Kim, Y.S.4    Ko, H.J.5    Kang, C.Y.6
  • 111
    • 58149332680 scopus 로고    scopus 로고
    • Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma
    • Kusmartsev S, Su Z, Heiser A et al. Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin. Cancer Res. 14(24), 8270-8278 (2008
    • (2008) Clin. Cancer Res , vol.14 , Issue.24 , pp. 8270-8278
    • Kusmartsev, S.1    Su, Z.2    Heiser, A.3
  • 112
    • 0042591427 scopus 로고    scopus 로고
    • All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination
    • Kusmartsev S, Cheng F, Yu B et al. All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res. 63(15), 4441-4449 (2003
    • (2003) Cancer Res , vol.63 , Issue.15 , pp. 4441-4449
    • Kusmartsev, S.1    Cheng, F.2    Yu, B.3
  • 113
    • 84255170450 scopus 로고    scopus 로고
    • PGE 2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment
    • Obermajer N, Muthuswamy R, Odunsi K, Edwards RP, Kalinski P. PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Res. 71(24), 7463-7470 (2011
    • (2011) Cancer Res. , vol.71 , Issue.24 , pp. 7463-7470
    • Obermajer, N.1    Muthuswamy, R.2    Odunsi, K.3    Edwards, R.P.4    Kalinski, P.5
  • 114
    • 84856760496 scopus 로고    scopus 로고
    • Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation
    • Umansky V, Sevko A. Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation. Cancer Immunol. Immunother. 61(2), 275-282 (2012
    • (2012) Cancer Immunol. Immunother , vol.61 , Issue.2 , pp. 275-282
    • Umansky, V.1    Sevko, A.2
  • 115
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8(3), 239-245 (2007
    • (2007) Nat. Immunol , vol.8 , Issue.3 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 116
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12(4), 252-264 (2012
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 117
    • 78049434917 scopus 로고    scopus 로고
    • Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques
    • Titanji K, Velu V, Chennareddi L et al. Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J. Clin. Invest. 120(11), 3878-3890 (2010
    • (2010) J. Clin. Invest , vol.120 , Issue.11 , pp. 3878-3890
    • Titanji, K.1    Velu, V.2    Chennareddi, L.3
  • 118
    • 80051698136 scopus 로고    scopus 로고
    • IL-18 induces PD-1-dependent immunosuppression in cancer
    • Terme M, Ullrich E, Aymeric L et al. IL-18 induces PD-1-dependent immunosuppression in cancer. Cancer Res. 71(16), 5393-5399 (2011
    • (2011) Cancer Res , vol.71 , Issue.16 , pp. 5393-5399
    • Terme, M.1    Ullrich, E.2    Aymeric, L.3
  • 119
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson DM Jr, Bakan CE, Mishra A et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 116(13), 2286-2294 (2010
    • (2010) Blood , vol.116 , Issue.13 , pp. 2286-2294
    • Benson, D.M.1    Bakan, C.E.2    Mishra, A.3
  • 120
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 66(7), 3381-3385 (2006
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3
  • 121
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J, Mandai M, Iwasaki M et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl Acad. Sci. USA 104(9), 3360-3365 (2007
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.9 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 122
    • 33745491116 scopus 로고    scopus 로고
    • Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
    • Wu C, Zhu Y, Jiang J, Zhao J, Zhang XG, Xu N. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem. 108(1), 19-24 (2006
    • (2006) Acta Histochem , vol.108 , Issue.1 , pp. 19-24
    • Wu, C.1    Zhu, Y.2    Jiang, J.3    Zhao, J.4    Zhang, X.G.5    Xu, N.6
  • 123
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    • Ohigashi Y, Sho M, Yamada Y et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin. Cancer Res. 11(8), 2947-2953 (2005
    • (2005) Clin. Cancer Res , vol.11 , Issue.8 , pp. 2947-2953
    • Ohigashi, Y.1    Sho, M.2    Yamada, Y.3
  • 124
    • 34250209885 scopus 로고    scopus 로고
    • Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma
    • Krambeck AE, Dong H, Thompson RH et al. Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Clin. Cancer Res. 13(6), 1749-1756 (2007
    • (2007) Clin. Cancer Res , vol.13 , Issue.6 , pp. 1749-1756
    • Krambeck, A.E.1    Dong, H.2    Thompson, R.H.3
  • 125
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao Q, Wang XY, Qiu SJ et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin. Cancer Res. 15(3), 971-979 (2009
    • (2009) Clin. Cancer Res , vol.15 , Issue.3 , pp. 971-979
    • Gao, Q.1    Wang, X.Y.2    Qiu, S.J.3
  • 126
    • 70349561448 scopus 로고    scopus 로고
    • PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
    • Zhang L, Gajewski TF, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 114(8), 1545-1552 (2009
    • (2009) Blood , vol.114 , Issue.8 , pp. 1545-1552
    • Zhang, L.1    Gajewski, T.F.2    Kline, J.3
  • 127
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8(8), 793-800 (2002
    • (2002) Nat. Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 128
    • 33745197352 scopus 로고    scopus 로고
    • Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
    • Blank C, Kuball J, Voelkl S et al. Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. Int. J. Cancer 119(2), 317-327 (2006
    • (2006) Int. J. Cancer , vol.119 , Issue.2 , pp. 317-327
    • Blank, C.1    Kuball, J.2    Voelkl, S.3
  • 129
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 130
    • 84908121916 scopus 로고    scopus 로고
    • MPDL3280A (anti-PDL1): Clinical activity, safety and biomarkers of an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • Hodi FS, Powles T, Cassier P et al. MPDL3280A (anti-PDL1): clinical activity, safety and biomarkers of an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. Eur. J. Cancer 49, S184-S184 (2013
    • (2013) Eur. J. Cancer , vol.49 , pp. S184-S184
    • Hodi, F.S.1    Powles, T.2    Cassier, P.3
  • 131
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010
    • (2010) J. Clin. Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 132
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 133
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369(2), 122-133 (2013
    • (2013) N. Engl. J. Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 134
    • 84892866206 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
    • Weber JS, Kudchadkar RR, Yu B et al. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J. Clin. Oncol. 31(34), 4311-4318 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.34 , pp. 4311-4318
    • Weber, J.S.1    Kudchadkar, R.R.2    Yu, B.3
  • 135
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, Rotem-Yehudar R, Slama G et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14(10), 3044-3051 (2008
    • (2008) Clin. Cancer Res , vol.14 , Issue.10 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3
  • 136
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international Phase II trial
    • Armand P, Nagler A, Weller EA et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international Phase II trial. J. Clin. Oncol. 31(33), 4199-4206 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.33 , pp. 4199-4206
    • Armand, P.1    Nagler, A.2    Weller, E.A.3
  • 137
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, Phase 2 trial
    • Westin JR, Chu F, Zhang M et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, Phase 2 trial. Lancet Oncol. 15(1), 69-77 (2014
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3
  • 138
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369(2), 134-144 (2013
    • (2013) N. Engl. J. Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 139
    • 84866537984 scopus 로고    scopus 로고
    • Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer
    • Salvi S, Fontana V, Boccardo S et al. Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer. Cancer Immunol. Immunother. 61(9), 1463-1472 (2012
    • (2012) Cancer Immunol. Immunother , vol.61 , Issue.9 , pp. 1463-1472
    • Salvi, S.1    Fontana, V.2    Boccardo, S.3
  • 140
    • 78649237729 scopus 로고    scopus 로고
    • New insights of CTLA-4 into its biological function in breast cancer
    • Mao H, Zhang L, Yang Y et al. New insights of CTLA-4 into its biological function in breast cancer. Curr. Cancer Drug Targets 10(7), 728-736 (2010
    • (2010) Curr. Cancer Drug Targets , vol.10 , Issue.7 , pp. 728-736
    • Mao, H.1    Zhang, L.2    Yang, Y.3
  • 141
    • 27144458821 scopus 로고    scopus 로고
    • CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction
    • Contardi E, Palmisano GL, Tazzari PL et al. CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. Int. J. Cancer 117(4), 538-550 (2005
    • (2005) Int. J. Cancer , vol.117 , Issue.4 , pp. 538-550
    • Contardi, E.1    Palmisano, G.L.2    Tazzari, P.L.3
  • 142
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2, 3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin. Cancer Res. 17(22), 6985-6991 (2011
    • (2011) Clin. Cancer Res , vol.17 , Issue.22 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 143
    • 33644775726 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2, 3-dioxygenase expression in colorectal cancer: Effect on tumor-infiltrating T cells
    • Brandacher G, Perathoner A, Ladurner R et al. Prognostic value of indoleamine 2, 3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells. Clin. Cancer Res. 12(4), 1144-1151 (2006
    • (2006) Clin. Cancer Res , vol.12 , Issue.4 , pp. 1144-1151
    • Brandacher, G.1    Perathoner, A.2    Ladurner, R.3
  • 144
    • 84872303786 scopus 로고    scopus 로고
    • Tumoral indoleamine 2, 3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma
    • Ye J, Liu H, Hu Y, Li P, Zhang G, Li Y. Tumoral indoleamine 2, 3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma. Virchows Arch. 462(1), 73-81 (2013
    • (2013) Virchows Arch , vol.462 , Issue.1 , pp. 73-81
    • Ye, J.1    Liu, H.2    Hu, Y.3    Li, P.4    Zhang, G.5    Li, Y.6
  • 145
    • 84869232447 scopus 로고    scopus 로고
    • IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival
    • Wainwright DA, Balyasnikova IV, Chang AL et al. IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clin. Cancer Res. 18(22), 6110-6121 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.22 , pp. 6110-6121
    • Wainwright, D.A.1    Balyasnikova, I.V.2    Chang, A.L.3
  • 146
    • 84865118647 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients
    • Speeckaert R, Vermaelen K, Van Geel N et al. Indoleamine 2, 3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients. Eur. J. Cancer 48(13), 2004-2011 (2012
    • (2012) Eur. J. Cancer , vol.48 , Issue.13 , pp. 2004-2011
    • Speeckaert, R.1    Vermaelen, K.2    Van Geel, N.3
  • 147
    • 75749113671 scopus 로고    scopus 로고
    • Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
    • Suzuki Y, Suda T, Furuhashi K et al. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. Lung Cancer 67(3), 361-365 (2010
    • (2010) Lung Cancer , vol.67 , Issue.3 , pp. 361-365
    • Suzuki, Y.1    Suda, T.2    Furuhashi, K.3
  • 148
    • 84863354166 scopus 로고    scopus 로고
    • Indoleamine-2, 3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy
    • Wang D, Saga Y, Mizukami H et al. Indoleamine-2, 3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy. Int. J. Oncol. 40(4), 929-934 (2012
    • (2012) Int. J. Oncol , vol.40 , Issue.4 , pp. 929-934
    • Wang, D.1    Saga, Y.2    Mizukami, H.3
  • 149
    • 77951718214 scopus 로고    scopus 로고
    • Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
    • Liu X, Shin N, Koblish HK et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 115(17), 3520-3530 (2010
    • (2010) Blood , vol.115 , Issue.17 , pp. 3520-3530
    • Liu, X.1    Shin, N.2    Koblish, H.K.3
  • 150
    • 84877004454 scopus 로고    scopus 로고
    • Cytokine patterns in patients with cancer: A systematic review
    • Lippitz BE. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol. 14(6), e218-e228 (2013
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. e218-e228
    • Lippitz, B.E.1
  • 151
    • 84885717570 scopus 로고    scopus 로고
    • Immunological effects of the TGFbeta-blocking antibody GC1008 in malignant pleural mesothelioma patients
    • Stevenson JP, Kindler HL, Papasavvas E et al. Immunological effects of the TGFbeta-blocking antibody GC1008 in malignant pleural mesothelioma patients. Oncoimmunology 2(8), e26218 (2013
    • (2013) Oncoimmunology , vol.2 , Issue.8 , pp. e26218
    • Stevenson, J.P.1    Kindler, H.L.2    Papasavvas, E.3
  • 152
    • 72049091524 scopus 로고    scopus 로고
    • Targeting the transforming growth factor-beta signaling pathway in human cancer
    • Nagaraj NS, Datta PK. Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin. Investig. Drugs 19(1), 77-91 (2010
    • (2010) Expert Opin. Investig. Drugs , vol.19 , Issue.1 , pp. 77-91
    • Nagaraj, N.S.1    Datta, P.K.2
  • 153
    • 84861651644 scopus 로고    scopus 로고
    • Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes
    • Carretero R, Wang E, Rodriguez AI et al. Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes. Int. J. Cancer 131(2), 387-395 (2012
    • (2012) Int. J. Cancer , vol.131 , Issue.2 , pp. 387-395
    • Carretero, R.1    Wang, E.2    Rodriguez, A.I.3
  • 154
    • 33947191443 scopus 로고    scopus 로고
    • Down-regulation of HLA class i antigen is an independent prognostic factor for clear cell renal cell carcinoma
    • Kitamura H, Honma I, Torigoe T, Asanuma H, Sato N, Tsukamoto T. Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. J. Urol. 177(4), 1269-1272 (2007
    • (2007) J. Urol , vol.177 , Issue.4 , pp. 1269-1272
    • Kitamura, H.1    Honma, I.2    Torigoe, T.3    Asanuma, H.4    Sato, N.5    Tsukamoto, T.6
  • 155
    • 77949448480 scopus 로고    scopus 로고
    • HLA class i antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis
    • Bandoh N, Ogino T, Katayama A et al. HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis. Oncol. Rep. 23(4), 933-939 (2010
    • (2010) Oncol. Rep , vol.23 , Issue.4 , pp. 933-939
    • Bandoh, N.1    Ogino, T.2    Katayama, A.3
  • 156
    • 0038666364 scopus 로고    scopus 로고
    • Characterization of human lymphocyte antigen class i antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation
    • Seliger B, Atkins D, Bock M et al. Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation. Clin. Cancer Res. 9(5), 1721-1727 (2003
    • (2003) Clin. Cancer Res , vol.9 , Issue.5 , pp. 1721-1727
    • Seliger, B.1    Atkins, D.2    Bock, M.3
  • 157
    • 78449285664 scopus 로고    scopus 로고
    • Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer
    • Kasajima A, Sers C, Sasano H et al. Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer. Hum. Pathol. 41(12), 1758-1769 (2010
    • (2010) Hum. Pathol , vol.41 , Issue.12 , pp. 1758-1769
    • Kasajima, A.1    Sers, C.2    Sasano, H.3
  • 158
    • 70350686895 scopus 로고    scopus 로고
    • Down-regulation of HLA class i antigen-processing machinery components in esophageal squamous cell carcinomas: Association with disease progression
    • Liu Q, Hao C, Su P, Shi J. Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression. Scand. J. Gastroenterol. 44(8), 960-969 (2009
    • (2009) Scand. J. Gastroenterol , vol.44 , Issue.8 , pp. 960-969
    • Liu, Q.1    Hao, C.2    Su, P.3    Shi, J.4
  • 159
    • 0034948650 scopus 로고    scopus 로고
    • Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is associated with progression to metastatic disease
    • Cresswell AC, Sisley K, Laws D, Parsons MA, Rennie IG, Murray AK. Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is associated with progression to metastatic disease. Melanoma Res. 11(3), 275-281 (2001
    • (2001) Melanoma Res , vol.11 , Issue.3 , pp. 275-281
    • Cresswell, A.C.1    Sisley, K.2    Laws, D.3    Parsons, M.A.4    Rennie, I.G.5    Murray, A.K.6
  • 160
    • 77449133036 scopus 로고    scopus 로고
    • Association of HLA class i antigen abnormalities with disease progression and early recurrence in prostate cancer
    • Seliger B, Stoehr R, Handke D et al. Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. Cancer Immunol. Immunother. 59(4), 529-540 (2010
    • (2010) Cancer Immunol. Immunother , vol.59 , Issue.4 , pp. 529-540
    • Seliger, B.1    Stoehr, R.2    Handke, D.3
  • 161
    • 11344290086 scopus 로고    scopus 로고
    • HLA class i antigen down-regulation in primary ovary carcinoma lesions: Association with disease stage
    • Vitale M, Pelusi G, Taroni B et al. HLA class I antigen down-regulation in primary ovary carcinoma lesions: association with disease stage. Clin. Cancer Res. 11(1), 67-72 (2005
    • (2005) Clin. Cancer Res , vol.11 , Issue.1 , pp. 67-72
    • Vitale, M.1    Pelusi, G.2    Taroni, B.3
  • 162
    • 0347759811 scopus 로고    scopus 로고
    • Down-regulation of HLA class i antigen processing molecules: An immune escape mechanism of renal cell carcinoma?
    • Pt1
    • Atkins D, Ferrone S, Schmahl GE, Storkel S, Seliger B Down-regulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma?. J. Urol. 171(2 Pt 1), 885-889 (2004
    • (2004) J. Urol , vol.171 , Issue.2 , pp. 885-889
    • Atkins, D.1    Ferrone, S.2    Schmahl, G.E.3    Storkel, S.4    Seliger, B.5
  • 163
    • 50349084447 scopus 로고    scopus 로고
    • HLA class i antigen processing machinery component expression and intratumoral T-cell infiltrate as independent prognostic markers in ovarian carcinoma
    • Han LY, Fletcher MS, Urbauer DL et al. HLA class I antigen processing machinery component expression and intratumoral T-cell infiltrate as independent prognostic markers in ovarian carcinoma. Clin. Cancer Res. 14(11), 3372-3379 (2008
    • (2008) Clin. Cancer Res , vol.14 , Issue.11 , pp. 3372-3379
    • Han, L.Y.1    Fletcher, M.S.2    Urbauer, D.L.3
  • 164
    • 0035915772 scopus 로고    scopus 로고
    • TAP1 down-regulation in primary melanoma lesions: An independent marker of poor prognosis
    • Kamarashev J, Ferrone S, Seifert B et al. TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis. Int. J. Cancer 95(1), 23-28 (2001
    • (2001) Int. J. Cancer , vol.95 , Issue.1 , pp. 23-28
    • Kamarashev, J.1    Ferrone, S.2    Seifert, B.3
  • 165
    • 84890325511 scopus 로고    scopus 로고
    • The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer
    • Mimura K, Shiraishi K, Mueller A et al. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J. Immunol. 191(12), 6261-6272 (2013
    • (2013) J. Immunol , vol.191 , Issue.12 , pp. 6261-6272
    • Mimura, K.1    Shiraishi, K.2    Mueller, A.3
  • 166
    • 80053648839 scopus 로고    scopus 로고
    • Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
    • Yuan J, Adamow M, Ginsberg BA et al. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc. Natl Acad. Sci. USA 108(40), 16723-16728 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.40 , pp. 16723-16728
    • Yuan, J.1    Adamow, M.2    Ginsberg, B.A.3
  • 167
    • 84878567974 scopus 로고    scopus 로고
    • Depleting tumor-specific Tregs at a single site eradicates disseminated tumors
    • Marabelle A, Kohrt H, Sagiv-Barfi I et al. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J. Clin. Invest. 123(6), 2447-2463 (2013
    • (2013) J. Clin. Invest , vol.123 , Issue.6 , pp. 2447-2463
    • Marabelle, A.1    Kohrt, H.2    Sagiv-Barfi, I.3
  • 168
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J. Clin. Invest. 124(2), 687-695 (2014
    • (2014) J. Clin. Invest , vol.124 , Issue.2 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 169
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
    • Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP. Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210(7), 1389-1402 (2013
    • (2013) J. Exp. Med , vol.210 , Issue.7 , pp. 1389-1402
    • Holmgaard, R.B.1    Zamarin, D.2    Munn, D.H.3    Wolchok, J.D.4    Allison, J.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.