Cutting edge: Cell-Extrinsic immune regulation by CTLA-4 expressed on conventional T cells

Journal of Immunology

Volumn 189, Issue 3, 2012, Pages 1118-1122

  Wang, Chun Jing ^a   Kenefeck, Rupert ^a   Wardzinski, Lukasz ^a   Attridge, Kesley ^a   Manzotti, Claire ^a   Schmidt, Emily M ^a   Qureshi, Omar S ^a   Sansom, David M ^a   Walker, Lucy S K ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOREGULATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; WASTING SYNDROME; WEIGHT REDUCTION;

ADOPTIVE TRANSFER; ANIMALS; BONE MARROW TRANSPLANTATION; CTLA-4 ANTIGEN; GROWTH INHIBITORS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RADIATION CHIMERA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84864123005     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200972     Document Type: Article

References (36)

1. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
2. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270: 985-988.
3. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1: 405-413.
4. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182: 459-465.
5. Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183: 2541-2550. (Pubitemid 26192364)
6. Krummel, M. F., and J. P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183: 2533-2540. (Pubitemid 26192363)
7. Tivol, E. A., S. D. Boyd, S. McKeon, F. Borriello, P. Nickerson, T. B. Strom, and A. H. Sharpe. 1997. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J. Immunol. 158: 5091-5094. (Pubitemid 127681209)
8. Mandelbrot, D. A., A. J. McAdam, and A. H. Sharpe. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189: 435-440. (Pubitemid 29063264)
9. Bachmann, M. F., G. Köhler, B. Ecabert, T. W. Mak, and M. Kopf. 1999. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163: 1128-1131. (Pubitemid 29352726)
10. Bachmann, M. F., P. Waterhouse, D. E. Speiser, K. McKall-Faienza, T. W. Mak, and P. S. Ohashi. 1998. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J. Immunol. 160: 95-100. (Pubitemid 28116719)
11. Bachmann, M. F., A. Gallimore, E. Jones, B. Ecabert, H. Acha-Orbea, and M. Kopf. 2001. Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur. J. Immunol. 31: 450-458. (Pubitemid 32166599)
12. Homann, D., W. Dummer, T. Wolfe, E. Rodrigo, A. N. Theofilopoulos, M. B. Oldstone, and M. G. von Herrath. 2006. Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity. J. Virol. 80: 270-280.
13. Metzler, B., C. Burkhart, and D. C. Wraith. 1999. Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo. Int. Immunol. 11: 667-675. (Pubitemid 29237758)
14. Read, S., V. Malmström, and F. Powrie. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302. (Pubitemid 30470312)
15. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192: 303-310.
16. + regulatory T cell function. Science 322: 271-275.
17. Read, S., R. Greenwald, A. Izcue, N. Robinson, D. Mandelbrot, L. Francisco, A. H. Sharpe, and F. Powrie. 2006. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J. Immunol. 177: 4376-4383. (Pubitemid 44469766)
18. Schmidt, E. M., C. J. Wang, G. A. Ryan, L. E. Clough, O. S. Qureshi, M. Goodall, A. K. Abbas, A. H. Sharpe, D. M. Sansom, and L. S. Walker. 2009. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J. Immunol. 182: 274-282.
19. + T-cell lymphopenia-induced proliferation. Eur. J. Immunol. 39: 1544-1551.
20. Kolar, P., K. Knieke, J. K. Hegel, D. Quandt, G. R. Burmester, H. Hoff, and M. C. Brunner-Weinzierl. 2009. CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum. 60: 123-132.
21. Ise, W., M. Kohyama, K. M. Nutsch, H. M. Lee, A. Suri, E. R. Unanue, T. L. Murphy, and K. M. Murphy. 2010. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat. Immunol. 11: 129-135.
22. Jain, N., H. Nguyen, C. Chambers, and J. Kang. 2010. Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity. Proc. Natl. Acad. Sci. USA 107: 1524-1528.
23. Greenwald, R. J., V. A. Boussiotis, R. B. Lorsbach, A. K. Abbas, and A. H. Sharpe. 2001. CTLA-4 regulates induction of anergy in vivo. Immunity 14: 145-155. (Pubitemid 32206517)
24. Eggena, M. P., L. S. Walker, V. Nagabhushanam, L. Barron, A. Chodos, and A. K. Abbas. 2004. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J. Exp. Med. 199: 1725-1730. (Pubitemid 38822006)
25. Peggs, K. S., S. A. Quezada, C. A. Chambers, A. J. Korman, and J. P. Allison. 2009. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 206: 1717-1725.
26. Walker, L. S., and D. M. Sansom. 2011. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat. Rev. Immunol. 11: 852-863.
27. Walker, L. S., L. J. Ausubel, A. Chodos, N. Bekarian, and A. K. Abbas. 2002. CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen. J. Immunol. 169: 6202-6209. (Pubitemid 36903466)
28. + regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J. Exp. Med. 206: 421-434.
29. Clough, L. E., C. J. Wang, E. M. Schmidt, G. Booth, T. Z. Hou, G. A. Ryan, and L. S. Walker. 2008. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 180: 5393-5401.
30. Qureshi, O. S., Y. Zheng, K. Nakamura, K. Attridge, C. Manzotti, E. M. Schmidt, J. Baker, L. E. Jeffery, S. Kaur, Z. Briggs, et al. 2011. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332: 600-603.
31. + regulatory CD4 T cells in response to tissue-restricted self antigen. J. Immunol. 186: 4551-4555.
32. Bour-Jordan, H., J. H. Esensten, M. Martinez-Llordella, C. Penaranda, M. Stumpf, and J. A. Bluestone. 2011. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family. Immunol. Rev. 241: 180-205.
33. Wing, K., T. Yamaguchi, and S. Sakaguchi. 2011. Cell-autonomous and -nonautonomous roles of CTLA-4 in immune regulation. Trends Immunol. 32: 428-433.
34. Thompson, C. B., and J. P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity 7: 445-450. (Pubitemid 27508696)
35. + T cells in vivo is rapid, transient, and influenced by TCR-specific competition. J. Immunol. 172: 6136-6143.
36. Corse, E., and J. P. Allison. 2012. Cutting edge: CTLA-4 on effector T cells inhibits in trans. J. Immunol. 189: 1123-1127.