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Volumn 73, Issue 8, 2013, Pages 2468-2479

Interleukin 21-induced granzyme b-expressing b cells infiltrate tumors and regulate t cells

(17)  Lindner, Stefanie a   Dahlke, Karen b   Sontheimer, Kai b   Hagn, Magdalena i   Kaltenmeier, Christof a   Barth, Thomas F E c   Beyer, Thamara a   Reister, Frank d   Fabricius, Dorit e   Lotfi, Ramin a,f   Lunov, Oleg b   Nienhaus, G Ulrich b,g,h   Simmet, Thomas b   Kreienberg, Rolf d   Moller, Peter c   Schrezenmeier, Hubert a,f   Jahrsdorfer, Bernd a,f,j  


Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD147 ANTIGEN; CD19 ANTIGEN; CD1D ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; GRANZYME B; IMMUNOGLOBULIN M; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84876991334     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3450     Document Type: Article
Times cited : (275)

References (47)
  • 1
    • 73249114021 scopus 로고    scopus 로고
    • Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity
    • Lampropoulou V, Calderon-Gomez E, Roch T, Neves P, Shen P, Stervbo U, et al. Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity. Immunol Rev 2010;233:146-61.
    • (2010) Immunol Rev , vol.233 , pp. 146-61
    • Lampropoulou, V.1    Calderon-Gomez, E.2    Roch, T.3    Neves, P.4    Shen, P.5    Stervbo, U.6
  • 2
    • 49249136452 scopus 로고    scopus 로고
    • Regulatory B cells as inhibitors of immune responses and inflammation
    • Bouaziz JD, Yanaba K, Tedder TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 2008;224:201-14.
    • (2008) Immunol Rev , vol.224 , pp. 201-14
    • Bouaziz, J.D.1    Yanaba, K.2    Tedder, T.F.3
  • 3
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003;197:489-501.
    • (2003) J Exp Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 4
    • 34247602173 scopus 로고    scopus 로고
    • B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
    • Wagner U, Kaltenhauser S, Pierer M, Wilke B, Arnold S, Hantzschel H. B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response. Arthritis Res 2002;4:R1.
    • (2002) Arthritis Res , vol.4
    • Wagner, U.1    Kaltenhauser, S.2    Pierer, M.3    Wilke, B.4    Arnold, S.5    Hantzschel, H.6
  • 5
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008;28:639-50.
    • (2008) Immunity , vol.28 , pp. 639-50
    • Yanaba, K.1    Bouaziz, J.D.2    Haas, K.M.3    Poe, J.C.4    Fujimoto, M.5    Tedder, T.F.6
  • 6
    • 75749087574 scopus 로고    scopus 로고
    • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer
    • DiLillo DJ, Matsushita T, Tedder TF. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 2010;1183:38-57.
    • (2010) Ann N Y Acad Sci , vol.1183 , pp. 38-57
    • DiLillo, D.J.1    Matsushita, T.2    Tedder, T.F.3
  • 7
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008;118:3420-30.
    • (2008) J Clin Invest , vol.118 , pp. 3420-30
    • Matsushita, T.1    Yanaba, K.2    Bouaziz, J.D.3    Fujimoto, M.4    Tedder, T.F.5
  • 8
    • 74649083783 scopus 로고    scopus 로고
    • CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
    • Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010;32:129-40.
    • (2010) Immunity , vol.32 , pp. 129-40
    • Blair, P.A.1    Norena, L.Y.2    Flores-Borja, F.3    Rawlings, D.J.4    Isenberg, D.A.5    Ehrenstein, M.R.6
  • 9
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M, DiLillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117: 530-41.
    • (2011) Blood , vol.117 , pp. 530-41
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3    DiLillo, D.J.4    Yanaba, K.5    Venturi, G.M.6
  • 10
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: Evolving concepts from the clinic
    • Martin F, Chan AC. B cell immunobiology in disease: Evolving concepts from the clinic. Annu Rev Immunol 2006;24:467-96.
    • (2006) Annu Rev Immunol , vol.24 , pp. 467-96
    • Martin, F.1    Chan, A.C.2
  • 11
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408: 57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3    Hammond, A.4    Sprecher, C.5    Gross, J.A.6
  • 12
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bimdependent apoptosis
    • Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bimdependent apoptosis. J Immunol 2004;173:657-65.
    • (2004) J Immunol , vol.173 , pp. 657-65
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 13
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R, Sims GP, Fairhurst AM, Robbins R, da Silva YS, Spolski R, et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005;175:7867-79.
    • (2005) J Immunol , vol.175 , pp. 7867-79
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3    Robbins, R.4    Da Silva, Y.S.5    Spolski, R.6
  • 14
    • 0037159687 scopus 로고    scopus 로고
    • Acritical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, et al.Acritical role for IL-21 in regulating immunoglobulin production. Science 2002;298: 1630-4.
    • (2002) Science , vol.298 , pp. 1630-4
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3    Qi, C.F.4    Cheng, J.5    Sher, A.6
  • 15
    • 77954122576 scopus 로고    scopus 로고
    • CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B
    • Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, Beyer T, et al. CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B. Eur J Immunol 2010;40:2060-9.
    • (2010) Eur J Immunol , vol.40 , pp. 2060-9
    • Hagn, M.1    Ebel, V.2    Sontheimer, K.3    Schwesinger, E.4    Lunov, O.5    Beyer, T.6
  • 16
    • 68149099548 scopus 로고    scopus 로고
    • Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21
    • Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol 2009;183: 1838-45.
    • (2009) J Immunol , vol.183 , pp. 1838-45
    • Hagn, M.1    Schwesinger, E.2    Ebel, V.3    Sontheimer, K.4    Maier, J.5    Beyer, T.6
  • 17
    • 13544271161 scopus 로고    scopus 로고
    • Cutting edge: Contact-mediated suppression by CD4+CD25+regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    • Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ. Cutting edge: Contact-mediated suppression by CD4+CD25+regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 2005;174:1783-6.
    • (2005) J Immunol , vol.174 , pp. 1783-6
    • Gondek, D.C.1    Lu, L.F.2    Quezada, S.A.3    Sakaguchi, S.4    Noelle, R.J.5
  • 20
    • 77949529017 scopus 로고    scopus 로고
    • Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
    • Jahrsdörfer B, Vollmer A, Blackwell SE, Maier J, Sontheimer K, Beyer T, et al. Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion. Blood 2010;115:1156-65.
    • (2010) Blood , vol.115 , pp. 1156-65
    • Jahrsdörfer, B.1    Vollmer, A.2    Blackwell, S.E.3    Maier, J.4    Sontheimer, K.5    Beyer, T.6
  • 21
    • 78650057188 scopus 로고    scopus 로고
    • IL-21 is an immune activator that also mediates suppression via IL-10
    • Spolski R, Leonard WJ. IL-21 is an immune activator that also mediates suppression via IL-10. Crit Rev Immunol 2010;30:559-70.
    • (2010) Crit Rev Immunol , vol.30 , pp. 559-70
    • Spolski, R.1    Leonard, W.J.2
  • 22
  • 23
    • 33746255647 scopus 로고    scopus 로고
    • Extracellular granzymes: Current perspectives
    • Buzza MS, Bird PI. Extracellular granzymes: Current perspectives. Biol Chem 2006;387:827-37.
    • (2006) Biol Chem , vol.387 , pp. 827-37
    • Buzza, M.S.1    Bird, P.I.2
  • 24
    • 0032055984 scopus 로고    scopus 로고
    • Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo
    • Spaeny-Dekking EH, Hanna WL, Wolbink AM, Wever PC, Kummer AJ, Swaak AJ, et al. Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo. J Immunol 1998;160:3610-6.
    • (1998) J Immunol , vol.160 , pp. 3610-6
    • Spaeny-Dekking, E.H.1    Hanna, W.L.2    Wolbink, A.M.3    Wever, P.C.4    Kummer, A.J.5    Swaak, A.J.6
  • 26
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • Ettinger R, Kuchen S, Lipsky PE. The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev 2008;223:60-86.
    • (2008) Immunol Rev , vol.223 , pp. 60-86
    • Ettinger, R.1    Kuchen, S.2    Lipsky, P.E.3
  • 27
    • 78149488860 scopus 로고    scopus 로고
    • CD20+ B cells: The other tumor-infiltrating lymphocytes
    • Nelson BH. CD20+ B cells: The other tumor-infiltrating lymphocytes. J Immunol 2010;185:4977-82.
    • (2010) J Immunol , vol.185 , pp. 4977-82
    • Nelson, B.H.1
  • 28
    • 68149141666 scopus 로고    scopus 로고
    • Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
    • Milne K, Kobel M, Kalloger SE, Barnes RO, Gao D, Gilks CB, et al. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS ONE 2009;4:e6412.
    • (2009) PLoS ONE , vol.4
    • Milne, K.1    Kobel, M.2    Kalloger, S.E.3    Barnes, R.O.4    Gao, D.5    Gilks, C.B.6
  • 29
    • 80052236068 scopus 로고    scopus 로고
    • Human solid tumors contain high endothelial venules: Association with T-and B-lymphocyte infiltration and favorable prognosis in breast cancer
    • Martinet L, Garrido I, Filleron T, Le Guellec S, Bellard E, Fournie JJ, et al. Human solid tumors contain high endothelial venules: Association with T-and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res 2011;71:5678-87.
    • (2011) Cancer Res , vol.71 , pp. 5678-87
    • Martinet, L.1    Garrido, I.2    Filleron, T.3    Le Guellec, S.4    Bellard, E.5    Fournie, J.J.6
  • 30
    • 13144253138 scopus 로고    scopus 로고
    • Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast
    • Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S. Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Arch 2005;446:10-4.
    • (2005) Virchows Arch , vol.446 , pp. 10-4
    • Kuroda, H.1    Tamaru, J.2    Sakamoto, G.3    Ohnisi, K.4    Itoyama, S.5
  • 31
    • 34247101731 scopus 로고    scopus 로고
    • Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism
    • Watt V, Ronchese F, Ritchie D. Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism. J Immunother 2007;30:323-32.
    • (2007) J Immunother , vol.30 , pp. 323-32
    • Watt, V.1    Ronchese, F.2    Ritchie, D.3
  • 33
    • 33644652161 scopus 로고    scopus 로고
    • NKand B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma
    • Dong HP, Elstrand MB, Holth A, Silins I, Berner A, Trope CG, et al. NKand B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma. Am J Clin Pathol 2006;125:451-8.
    • (2006) Am J Clin Pathol , vol.125 , pp. 451-8
    • Dong, H.P.1    Elstrand, M.B.2    Holth, A.3    Silins, I.4    Berner, A.5    Trope, C.G.6
  • 35
    • 9644303148 scopus 로고    scopus 로고
    • IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus
    • Diaz-Alderete A, Crispin JC, Vargas-Rojas MI, Alcocer-Varela J. IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus. J Autoimmun 2004;23:379-83.
    • (2004) J Autoimmun , vol.23 , pp. 379-83
    • Diaz-Alderete, A.1    Crispin, J.C.2    Vargas-Rojas, M.I.3    Alcocer-Varela, J.4
  • 36
    • 0034176031 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation
    • Hwu P, Du MX, Lapointe R, Do M, Taylor MW, Young HA. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000;164:3596-9.
    • (2000) J Immunol , vol.164 , pp. 3596-9
    • Hwu, P.1    Du, M.X.2    Lapointe, R.3    Do, M.4    Taylor, M.W.5    Young, H.A.6
  • 37
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007; 8:1353-62.
    • (2007) Nat Immunol , vol.8 , pp. 1353-62
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 38
    • 36249022697 scopus 로고    scopus 로고
    • Competition for cytokines: T(reg) cells take all
    • Scheffold A, Murphy KM, Hofer T. Competition for cytokines: T(reg) cells take all. Nat Immunol 2007;8:1285-7.
    • (2007) Nat Immunol , vol.8 , pp. 1285-7
    • Scheffold, A.1    Murphy, K.M.2    Hofer, T.3
  • 39
    • 81055148068 scopus 로고    scopus 로고
    • CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+activated human regulatory T cells
    • Solstad T, Bains SJ, Landskron J, Aandahl EM, Thiede B, Tasken K, et al. CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+activated human regulatory T cells. Blood 2011;118:5141-51.
    • (2011) Blood , vol.118 , pp. 5141-51
    • Solstad, T.1    Bains, S.J.2    Landskron, J.3    Aandahl, E.M.4    Thiede, B.5    Tasken, K.6
  • 40
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-9.
    • (2005) J Exp Med , vol.202 , pp. 1131-9
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6
  • 41
    • 61449255987 scopus 로고    scopus 로고
    • IL-21: An executor of B cell fate
    • Konforte D, Simard N, Paige CJ. IL-21: An executor of B cell fate. J Immunol 2009;182:1781-7.
    • (2009) J Immunol , vol.182 , pp. 1781-7
    • Konforte, D.1    Simard, N.2    Paige, C.J.3
  • 42
    • 77957145333 scopus 로고    scopus 로고
    • What are regulatory B cells?
    • Gray D, Gray M. What are regulatory B cells? Eur J Immunol 2010; 40:2677-9.
    • (2010) Eur J Immunol , vol.40 , pp. 2677-9
    • Gray, D.1    Gray, M.2
  • 43
    • 58149402498 scopus 로고    scopus 로고
    • Induction of CD4+ T-cell anergy and apoptosis by activated human B cells
    • Tretter T, Venigalla RK, Eckstein V, Saffrich R, Sertel S, Ho AD, et al. Induction of CD4+ T-cell anergy and apoptosis by activated human B cells. Blood 2008;112:4555-64.
    • (2008) Blood , vol.112 , pp. 4555-64
    • Tretter, T.1    Venigalla, R.K.2    Eckstein, V.3    Saffrich, R.4    Sertel, S.5    Ho, A.D.6
  • 44
    • 84859132892 scopus 로고    scopus 로고
    • Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1
    • Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight DA, et al. Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1. PLoS ONE 2012;7:e33163.
    • (2012) PLoS ONE , vol.7
    • Boivin, W.A.1    Shackleford, M.2    Vanden Hoek, A.3    Zhao, H.4    Hackett, T.L.5    Knight, D.A.6
  • 46
    • 84860220430 scopus 로고    scopus 로고
    • Tumor-dependent down-regulation of the zeta-chain in T-cells is detectable in early breast cancer and correlates with immune cell function
    • De Boniface J, Poschke I, Mao Y, Kiessling R. Tumor-dependent down-regulation of the zeta-chain in T-cells is detectable in early breast cancer and correlates with immune cell function. Int J Cancer 2012;131:129-39.
    • (2012) Int J Cancer , vol.131 , pp. 129-39
    • De Boniface, J.1    Poschke, I.2    Mao, Y.3    Kiessling, R.4
  • 47
    • 84866772544 scopus 로고    scopus 로고
    • Interleukin-21 has activity in patients with metastatic melanoma: A phase II study
    • Petrella TM, Tozer R, Belanger K, Savage KJ, Wong R, Smylie M, et al. Interleukin-21 has activity in patients with metastatic melanoma: A phase II study. J Clin Oncol 2012;30:3396-401.
    • (2012) J Clin Oncol , vol.30 , pp. 3396-401
    • Petrella, T.M.1    Tozer, R.2    Belanger, K.3    Savage, K.J.4    Wong, R.5    Smylie, M.6


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