-
1
-
-
0037811736
-
Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
-
Peterson A.C., Harlin H., Gajewski T.F. Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J Clin Oncol 2003, 21:2342-2348.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2342-2348
-
-
Peterson, A.C.1
Harlin, H.2
Gajewski, T.F.3
-
2
-
-
59849116262
-
Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients
-
Fourcade J., Kudela P., Andrade Filho P.A., Janjic B., Land S.R., Sander C., Krieg A., Donnenberg A., Shen H., Kirkwood J.M., et al. Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients. J Immunother 2008, 31:781-791.
-
(2008)
J Immunother
, vol.31
, pp. 781-791
-
-
Fourcade, J.1
Kudela, P.2
Andrade Filho, P.A.3
Janjic, B.4
Land, S.R.5
Sander, C.6
Krieg, A.7
Donnenberg, A.8
Shen, H.9
Kirkwood, J.M.10
-
3
-
-
47949129948
-
Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
-
Adams S., O'Neill D.W., Nonaka D., Hardin E., Chiriboga L., Siu K., Cruz C.M., Angiulli A., Angiulli F., Ritter E., et al. Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J Immunol 2008, 181:776-784.
-
(2008)
J Immunol
, vol.181
, pp. 776-784
-
-
Adams, S.1
O'Neill, D.W.2
Nonaka, D.3
Hardin, E.4
Chiriboga, L.5
Siu, K.6
Cruz, C.M.7
Angiulli, A.8
Angiulli, F.9
Ritter, E.10
-
4
-
-
0031890206
-
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma [see comments]
-
Rosenberg S.A., Yang J.C., Schwartzentruber D.J., Hwu P., Marincola F.M., Topalian S.L., Restifo N.P., Dudley M.E., Schwarz S.L., Spiess P.J., et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma [see comments]. Nat Med 1998, 4:321-327.
-
(1998)
Nat Med
, vol.4
, pp. 321-327
-
-
Rosenberg, S.A.1
Yang, J.C.2
Schwartzentruber, D.J.3
Hwu, P.4
Marincola, F.M.5
Topalian, S.L.6
Restifo, N.P.7
Dudley, M.E.8
Schwarz, S.L.9
Spiess, P.J.10
-
5
-
-
36549013718
-
Chemokines expressed in melanoma metastases associated with T cell infiltration
-
2007 ASCO Annual Meeting Proceedings Part I
-
Gajewski T.F., Meng Y., Harlin H. Chemokines expressed in melanoma metastases associated with T cell infiltration. J Clin Oncol 2007, 25:8501.
-
(2007)
J Clin Oncol
, vol.25
, pp. 8501
-
-
Gajewski, T.F.1
Meng, Y.2
Harlin, H.3
-
6
-
-
77958006271
-
Association of gene expression profile in melanoma and survival to a dendritic cell-based vaccine
-
Gajewski T.F., Zha Y., Thurner B., Schuler G. Association of gene expression profile in melanoma and survival to a dendritic cell-based vaccine. J Clin Oncol 2009, 27:9002.
-
(2009)
J Clin Oncol
, vol.27
, pp. 9002
-
-
Gajewski, T.F.1
Zha, Y.2
Thurner, B.3
Schuler, G.4
-
7
-
-
66149156276
-
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
-
Harlin H., Meng Y., Peterson A.C., Zha Y., Tretiakova M., Slingluff C., McKee M., Gajewski T.F. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 2009, 69:3077-3085.
-
(2009)
Cancer Res
, vol.69
, pp. 3077-3085
-
-
Harlin, H.1
Meng, Y.2
Peterson, A.C.3
Zha, Y.4
Tretiakova, M.5
Slingluff, C.6
McKee, M.7
Gajewski, T.F.8
-
8
-
-
70350572075
-
Expression of defined genes identified by pre-treatment tumor profiling: association with clinical responses to the GSK MAGE-A3 immunotherapeutic in metastatic melanoma patients
-
(Abstract 9045)
-
Louahed J., Gruselle O., Gaulis S., Coche T., Eggermont A.M., Kruit W., Dreno B., Charion Sileni V., Lehmann F., Brichard V.G. Expression of defined genes identified by pre-treatment tumor profiling: association with clinical responses to the GSK MAGE-A3 immunotherapeutic in metastatic melanoma patients. J Clin Oncol 2008, 26. (Abstract 9045).
-
(2008)
J Clin Oncol
, vol.26
-
-
Louahed, J.1
Gruselle, O.2
Gaulis, S.3
Coche, T.4
Eggermont, A.M.5
Kruit, W.6
Dreno, B.7
Charion Sileni, V.8
Lehmann, F.9
Brichard, V.G.10
-
9
-
-
77958012775
-
Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapy
-
Gajewski T.F., Louahed J., Brichard V.G. Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapy. Cancer J 2010, 16:399-403.
-
(2010)
Cancer J
, vol.16
, pp. 399-403
-
-
Gajewski, T.F.1
Louahed, J.2
Brichard, V.G.3
-
10
-
-
82155168544
-
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
Hamid O., Schmidt H., Nissan A., Ridolfi L., Aamdal S., Hansson J., Guida M., Hyams D.M., Gomez H., Bastholt L., et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 2011, 9:204.
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
Ridolfi, L.4
Aamdal, S.5
Hansson, J.6
Guida, M.7
Hyams, D.M.8
Gomez, H.9
Bastholt, L.10
-
11
-
-
84862769116
-
An immune-active tumor microenvironment favors clinical response to ipilimumab
-
Ji R.R., Chasalow S.D., Wang L., Hamid O., Schmidt H., Cogswell J., Alaparthy S., Berman D., Jure-Kunkel M., Siemers N.O., et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 2011, 61:1019-1031.
-
(2011)
Cancer Immunol Immunother
, vol.61
, pp. 1019-1031
-
-
Ji, R.R.1
Chasalow, S.D.2
Wang, L.3
Hamid, O.4
Schmidt, H.5
Cogswell, J.6
Alaparthy, S.7
Berman, D.8
Jure-Kunkel, M.9
Siemers, N.O.10
-
12
-
-
79952980159
-
Molecular profiling of melanoma and the evolution of patient-specific therapy
-
Gajewski T.F. Molecular profiling of melanoma and the evolution of patient-specific therapy. Semin Oncol 2011, 38:236-242.
-
(2011)
Semin Oncol
, vol.38
, pp. 236-242
-
-
Gajewski, T.F.1
-
13
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
Pleasance E.D., Cheetham R.K., Stephens P.J., McBride D.J., Humphray S.J., Greenman C.D., Varela I., Lin M.L., Ordonez G.R., Bignell G.R., et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 2010, 463:191-196.
-
(2010)
Nature
, vol.463
, pp. 191-196
-
-
Pleasance, E.D.1
Cheetham, R.K.2
Stephens, P.J.3
McBride, D.J.4
Humphray, S.J.5
Greenman, C.D.6
Varela, I.7
Lin, M.L.8
Ordonez, G.R.9
Bignell, G.R.10
-
14
-
-
80355136945
-
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8alpha+ dendritic cells
-
Fuertes M.B., Kacha A.K., Kline J., Woo S.R., Kranz D.M., Murphy K.M., Gajewski T.F. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8alpha+ dendritic cells. J Exp Med 2011.
-
(2011)
J Exp Med
-
-
Fuertes, M.B.1
Kacha, A.K.2
Kline, J.3
Woo, S.R.4
Kranz, D.M.5
Murphy, K.M.6
Gajewski, T.F.7
-
15
-
-
84873111794
-
Type I interferon response and innate immune sensing of cancer
-
Fuertes M.B., Woo S.R., Burnett B., Fu Y.X., Gajewski T.F. Type I interferon response and innate immune sensing of cancer. Trends Immunol 2012, 34:67-73.
-
(2012)
Trends Immunol
, vol.34
, pp. 67-73
-
-
Fuertes, M.B.1
Woo, S.R.2
Burnett, B.3
Fu, Y.X.4
Gajewski, T.F.5
-
16
-
-
80355147292
-
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
-
Diamond M.S., Kinder M., Matsushita H., Mashayekhi M., Dunn G.P., Archambault J.M., Lee H., Arthur C.D., White J.M., Kalinke U., et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 2011, 208:1989-2003.
-
(2011)
J Exp Med
, vol.208
, pp. 1989-2003
-
-
Diamond, M.S.1
Kinder, M.2
Matsushita, H.3
Mashayekhi, M.4
Dunn, G.P.5
Archambault, J.M.6
Lee, H.7
Arthur, C.D.8
White, J.M.9
Kalinke, U.10
-
17
-
-
79951679142
-
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
-
Barber G.N. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 2011, 23:10-20.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 10-20
-
-
Barber, G.N.1
-
18
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa H., Ma Z., Barber G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461:788-792.
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
19
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Unterholzner L., Keating S.E., Baran M., Horan K.A., Jensen S.B., Sharma S., Sirois C.M., Jin T., Latz E., Xiao T.S., et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010, 11:997-1004.
-
(2010)
Nat Immunol
, vol.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
Horan, K.A.4
Jensen, S.B.5
Sharma, S.6
Sirois, C.M.7
Jin, T.8
Latz, E.9
Xiao, T.S.10
-
20
-
-
84864144593
-
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
-
Holm C.K., Jensen S.B., Jakobsen M.R., Cheshenko N., Horan K.A., Moeller H.B., Gonzalez-Dosal R., Rasmussen S.B., Christensen M.H., Yarovinsky T.O., et al. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nat Immunol 2012, 13:737-743.
-
(2012)
Nat Immunol
, vol.13
, pp. 737-743
-
-
Holm, C.K.1
Jensen, S.B.2
Jakobsen, M.R.3
Cheshenko, N.4
Horan, K.A.5
Moeller, H.B.6
Gonzalez-Dosal, R.7
Rasmussen, S.B.8
Christensen, M.H.9
Yarovinsky, T.O.10
-
21
-
-
34548438559
-
High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus
-
Niewold T.B., Hua J., Lehman T.J., Harley J.B., Crow M.K. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007, 8:492-502.
-
(2007)
Genes Immun
, vol.8
, pp. 492-502
-
-
Niewold, T.B.1
Hua, J.2
Lehman, T.J.3
Harley, J.B.4
Crow, M.K.5
-
22
-
-
84856301080
-
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
-
Gall A., Treuting P., Elkon K.B., Loo Y.M., Gale M., Barber G.N., Stetson D.B. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012, 36:120-131.
-
(2012)
Immunity
, vol.36
, pp. 120-131
-
-
Gall, A.1
Treuting, P.2
Elkon, K.B.3
Loo, Y.M.4
Gale, M.5
Barber, G.N.6
Stetson, D.B.7
-
23
-
-
84869794842
-
STING manifests self DNA-dependent inflammatory disease
-
Ahn J., Gutman D., Saijo S., Barber G.N. STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A 2012, 109:19386-19391.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 19386-19391
-
-
Ahn, J.1
Gutman, D.2
Saijo, S.3
Barber, G.N.4
-
25
-
-
79951740151
-
Type I interferon inhibits interleukin-1 production and inflammasome activation
-
Guarda G., Braun M., Staehli F., Tardivel A., Mattmann C., Forster I., Farlik M., Decker T., Du Pasquier R.A., Romero P., et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 2011, 34:213-223.
-
(2011)
Immunity
, vol.34
, pp. 213-223
-
-
Guarda, G.1
Braun, M.2
Staehli, F.3
Tardivel, A.4
Mattmann, C.5
Forster, I.6
Farlik, M.7
Decker, T.8
Du Pasquier, R.A.9
Romero, P.10
-
26
-
-
10744227434
-
Priming of naive T cells inside tumors leads to eradication of established tumors
-
Yu P., Lee Y., Liu W., Chin R.K., Wang J., Wang Y., Schietinger A., Philip M., Schreiber H., Fu Y.X. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol 2004, 5:141-149.
-
(2004)
Nat Immunol
, vol.5
, pp. 141-149
-
-
Yu, P.1
Lee, Y.2
Liu, W.3
Chin, R.K.4
Wang, J.5
Wang, Y.6
Schietinger, A.7
Philip, M.8
Schreiber, H.9
Fu, Y.X.10
-
27
-
-
34548646455
-
Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases
-
Yu P., Lee Y., Wang Y., Liu X., Auh S., Gajewski T.F., Schreiber H., You Z., Kaynor C., Wang X., et al. Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases. J Immunol 2007, 179:1960-1968.
-
(2007)
J Immunol
, vol.179
, pp. 1960-1968
-
-
Yu, P.1
Lee, Y.2
Wang, Y.3
Liu, X.4
Auh, S.5
Gajewski, T.F.6
Schreiber, H.7
You, Z.8
Kaynor, C.9
Wang, X.10
-
28
-
-
84860537877
-
Adenovirally delivered IFN-beta exerts antitumor effects through transient T-lymphocyte depletion and Ag-specific T-cell proliferation
-
Oh S.S., Moon C., Kim D.H., Song H., Park S., Fu Y., Kim K.D. Adenovirally delivered IFN-beta exerts antitumor effects through transient T-lymphocyte depletion and Ag-specific T-cell proliferation. Int J Mol Med 2012, 29:1153-1157.
-
(2012)
Int J Mol Med
, vol.29
, pp. 1153-1157
-
-
Oh, S.S.1
Moon, C.2
Kim, D.H.3
Song, H.4
Park, S.5
Fu, Y.6
Kim, K.D.7
-
29
-
-
79953295544
-
The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity
-
Burnette B.C., Liang H., Lee Y., Chlewicki L., Khodarev N.N., Weichselbaum R.R., Fu Y.X., Auh S.L. The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res 2011, 71:2488-2496.
-
(2011)
Cancer Res
, vol.71
, pp. 2488-2496
-
-
Burnette, B.C.1
Liang, H.2
Lee, Y.3
Chlewicki, L.4
Khodarev, N.N.5
Weichselbaum, R.R.6
Fu, Y.X.7
Auh, S.L.8
-
30
-
-
38049000452
-
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
-
Buckanovich R.J., Facciabene A., Kim S., Benencia F., Sasaroli D., Balint K., Katsaros D., O'Brien-Jenkins A., Gimotty P.A., Coukos G. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med 2008, 14:28-36.
-
(2008)
Nat Med
, vol.14
, pp. 28-36
-
-
Buckanovich, R.J.1
Facciabene, A.2
Kim, S.3
Benencia, F.4
Sasaroli, D.5
Balint, K.6
Katsaros, D.7
O'Brien-Jenkins, A.8
Gimotty, P.A.9
Coukos, G.10
-
31
-
-
80053159303
-
The parallel lives of angiogenesis and immunosuppression: cancer and other tales
-
Motz G.T., Coukos G. The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat Rev Immunol 2011, 11:702-711.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 702-711
-
-
Motz, G.T.1
Coukos, G.2
-
32
-
-
0026547421
-
Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells
-
Singh S., Ross S.R., Acena M., Rowley D.A., Schreiber H. Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells. J Exp Med 1992, 175:139-146.
-
(1992)
J Exp Med
, vol.175
, pp. 139-146
-
-
Singh, S.1
Ross, S.R.2
Acena, M.3
Rowley, D.A.4
Schreiber, H.5
-
33
-
-
40449105940
-
Equilibrium between host and cancer caused by effector T cells killing tumor stroma
-
Zhang B., Zhang Y., Bowerman N.A., Schietinger A., Fu Y.X., Kranz D.M., Rowley D.A., Schreiber H. Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res 2008, 68:1563-1571.
-
(2008)
Cancer Res
, vol.68
, pp. 1563-1571
-
-
Zhang, B.1
Zhang, Y.2
Bowerman, N.A.3
Schietinger, A.4
Fu, Y.X.5
Kranz, D.M.6
Rowley, D.A.7
Schreiber, H.8
-
34
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty G.L., Chiorean E.G., Fishman M.P., Saboury B., Teitelbaum U.R., Sun W., Huhn R.D., Song W., Li D., Sharp L.L., et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011, 331:1612-1616.
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
Saboury, B.4
Teitelbaum, U.R.5
Sun, W.6
Huhn, R.D.7
Song, W.8
Li, D.9
Sharp, L.L.10
-
35
-
-
0032718891
-
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo
-
Niu G., Heller R., Catlett-Falcone R., Coppola D., Jaroszeski M., Dalton W., Jove R., Yu H. Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res 1999, 59:5059-5063.
-
(1999)
Cancer Res
, vol.59
, pp. 5059-5063
-
-
Niu, G.1
Heller, R.2
Catlett-Falcone, R.3
Coppola, D.4
Jaroszeski, M.5
Dalton, W.6
Jove, R.7
Yu, H.8
-
36
-
-
20144376844
-
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
-
Burdelya L., Kujawski M., Niu G., Zhong B., Wang T., Zhang S., Kortylewski M., Shain K., Kay H., Djeu J., et al. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J Immunol 2005, 174:3925-3931.
-
(2005)
J Immunol
, vol.174
, pp. 3925-3931
-
-
Burdelya, L.1
Kujawski, M.2
Niu, G.3
Zhong, B.4
Wang, T.5
Zhang, S.6
Kortylewski, M.7
Shain, K.8
Kay, H.9
Djeu, J.10
-
37
-
-
41549123803
-
Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy
-
Ugurel S., Schrama D., Keller G., Schadendorf D., Brocker E.B., Houben R., Zapatka M., Fink W., Kaufman H.L., Becker J.C. Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy. Cancer Immunol Immunother 2008, 57:685-691.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 685-691
-
-
Ugurel, S.1
Schrama, D.2
Keller, G.3
Schadendorf, D.4
Brocker, E.B.5
Houben, R.6
Zapatka, M.7
Fink, W.8
Kaufman, H.L.9
Becker, J.C.10
-
38
-
-
77953913586
-
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
-
Wu H.J., Ivanov I.I., Darce J., Hattori K., Shima T., Umesaki Y., Littman D.R., Benoist C., Mathis D. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010, 32:815-827.
-
(2010)
Immunity
, vol.32
, pp. 815-827
-
-
Wu, H.J.1
Ivanov, I.I.2
Darce, J.3
Hattori, K.4
Shima, T.5
Umesaki, Y.6
Littman, D.R.7
Benoist, C.8
Mathis, D.9
-
39
-
-
84868252990
-
CMV and immunosenescence: from basics to clinics
-
Solana R., Tarazona R., Aiello A.E., Akbar A.N., Appay V., Beswick M., Bosch J.A., Campos C., Cantisan S., Cicin-Sain L., et al. CMV and immunosenescence: from basics to clinics. Immun Ageing 2012, 9:23.
-
(2012)
Immun Ageing
, vol.9
, pp. 23
-
-
Solana, R.1
Tarazona, R.2
Aiello, A.E.3
Akbar, A.N.4
Appay, V.5
Beswick, M.6
Bosch, J.A.7
Campos, C.8
Cantisan, S.9
Cicin-Sain, L.10
-
40
-
-
33745632047
-
Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites
-
Harlin H., Kuna T.V., Peterson A.C., Meng Y., Gajewski T.F. Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites. Cancer Immunol Immunother 2006, 55:1185-1197.
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 1185-1197
-
-
Harlin, H.1
Kuna, T.V.2
Peterson, A.C.3
Meng, Y.4
Gajewski, T.F.5
-
41
-
-
0038181111
-
Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma
-
Mortarini R., Piris A., Maurichi A., Molla A., Bersani I., Bono A., Bartoli C., Santinami M., Lombardo C., Ravagnani F., et al. Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma. Cancer Res 2003, 63:2535-2545.
-
(2003)
Cancer Res
, vol.63
, pp. 2535-2545
-
-
Mortarini, R.1
Piris, A.2
Maurichi, A.3
Molla, A.4
Bersani, I.5
Bono, A.6
Bartoli, C.7
Santinami, M.8
Lombardo, C.9
Ravagnani, F.10
-
42
-
-
33746214819
-
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
-
Appay V., Jandus C., Voelter V., Reynard S., Coupland S.E., Rimoldi D., Lienard D., Guillaume P., Krieg A.M., Cerottini J.C., et al. New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol 2006, 177:1670-1678.
-
(2006)
J Immunol
, vol.177
, pp. 1670-1678
-
-
Appay, V.1
Jandus, C.2
Voelter, V.3
Reynard, S.4
Coupland, S.E.5
Rimoldi, D.6
Lienard, D.7
Guillaume, P.8
Krieg, A.M.9
Cerottini, J.C.10
-
43
-
-
34848819211
-
Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment
-
Gajewski T.F. Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment. Clin Cancer Res 2007, 13:5256-5261.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5256-5261
-
-
Gajewski, T.F.1
-
44
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
-
Dong H., Strome S.E., Salomao D.R., Tamura H., Hirano F., Flies D.B., Roche P.C., Lu J., Zhu G., Tamada K., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8:793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
Flies, D.B.6
Roche, P.C.7
Lu, J.8
Zhu, G.9
Tamada, K.10
-
45
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M., Johnson L.A., Heemskerk B., Wunderlich J.R., Dudley M.E., White D.E., Rosenberg S.A. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009, 114:1537-1544.
-
(2009)
Blood
, vol.114
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
Johnson, L.A.2
Heemskerk, B.3
Wunderlich, J.R.4
Dudley, M.E.5
White, D.E.6
Rosenberg, S.A.7
-
46
-
-
79956048616
-
Progressive upregulation of PD-1 in primary and metastatic melanomas associated with blunted TCR signaling in infiltrating T lymphocytes
-
Chapon M., Randriamampita C., Maubec E., Badoual C., Fouquet S., Wang S.F., Marinho E., Farhi D., Garcette M., Jacobelli S., et al. Progressive upregulation of PD-1 in primary and metastatic melanomas associated with blunted TCR signaling in infiltrating T lymphocytes. J Invest Dermatol 2011, 131:1300-1307.
-
(2011)
J Invest Dermatol
, vol.131
, pp. 1300-1307
-
-
Chapon, M.1
Randriamampita, C.2
Maubec, E.3
Badoual, C.4
Fouquet, S.5
Wang, S.F.6
Marinho, E.7
Farhi, D.8
Garcette, M.9
Jacobelli, S.10
-
47
-
-
0035221101
-
Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
-
Mellor A.L., Sivakumar J., Chandler P., Smith K., Molina H., Mao D., Munn D.H. Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat Immunol 2001, 2:64-68.
-
(2001)
Nat Immunol
, vol.2
, pp. 64-68
-
-
Mellor, A.L.1
Sivakumar, J.2
Chandler, P.3
Smith, K.4
Molina, H.5
Mao, D.6
Munn, D.H.7
-
48
-
-
0842286646
-
IDO and tolerance to tumors
-
Munn D.H., Mellor A.L. IDO and tolerance to tumors. Trends Mol Med 2004, 10:15-18.
-
(2004)
Trends Mol Med
, vol.10
, pp. 15-18
-
-
Munn, D.H.1
Mellor, A.L.2
-
49
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-949.
-
(2004)
Nat Med
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
Coukos, G.2
Zou, L.3
Alvarez, X.4
Cheng, P.5
Mottram, P.6
Evdemon-Hogan, M.7
Conejo-Garcia, J.R.8
Zhang, L.9
Burow, M.10
-
50
-
-
52549083059
-
Selective accumulation of differentiated FOXP3(+) CD4(+) T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood
-
Jandus C., Bioley G., Speiser D.E., Romero P. Selective accumulation of differentiated FOXP3(+) CD4(+) T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood. Cancer Immunol Immunother 2008, 57:1795-1805.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1795-1805
-
-
Jandus, C.1
Bioley, G.2
Speiser, D.E.3
Romero, P.4
-
51
-
-
84871885298
-
Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
-
Zheng Y., Zha Y., Driessens G., Locke F., Gajewski T.F. Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med 2012, 209:2157-2163.
-
(2012)
J Exp Med
, vol.209
, pp. 2157-2163
-
-
Zheng, Y.1
Zha, Y.2
Driessens, G.3
Locke, F.4
Gajewski, T.F.5
-
52
-
-
0038796692
-
B7-H1 pathway and its role in the evasion of tumor immunity
-
Dong H., Chen L. B7-H1 pathway and its role in the evasion of tumor immunity. J Mol Med 2003, 81:281-287.
-
(2003)
J Mol Med
, vol.81
, pp. 281-287
-
-
Dong, H.1
Chen, L.2
-
53
-
-
0842325739
-
PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells
-
Blank C., Brown I., Peterson A.C., Spiotto M., Iwai Y., Honjo T., Gajewski T.F. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 2004, 64:1140-1145.
-
(2004)
Cancer Res
, vol.64
, pp. 1140-1145
-
-
Blank, C.1
Brown, I.2
Peterson, A.C.3
Spiotto, M.4
Iwai, Y.5
Honjo, T.6
Gajewski, T.F.7
-
54
-
-
70349561448
-
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
-
Zhang L., Gajewski T.F., Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 2009, 114:1545-1552.
-
(2009)
Blood
, vol.114
, pp. 1545-1552
-
-
Zhang, L.1
Gajewski, T.F.2
Kline, J.3
-
55
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
-
Uyttenhove C., Pilotte L., Theate I., Stroobant V., Colau D., Parmentier N., Boon T., Van Den Eynde B.J. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003, 9:1269-1274.
-
(2003)
Nat Med
, vol.9
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Theate, I.3
Stroobant, V.4
Colau, D.5
Parmentier, N.6
Boon, T.7
Van Den Eynde, B.J.8
-
56
-
-
77951718214
-
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
-
Liu X., Shin N., Koblish H.K., Yang G., Wang Q., Wang K., Leffet L., Hansbury M.J., Thomas B., Rupar M., et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 2010, 115:3520-3530.
-
(2010)
Blood
, vol.115
, pp. 3520-3530
-
-
Liu, X.1
Shin, N.2
Koblish, H.K.3
Yang, G.4
Wang, Q.5
Wang, K.6
Leffet, L.7
Hansbury, M.J.8
Thomas, B.9
Rupar, M.10
-
57
-
-
36148939150
-
IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
-
Litzinger M.T., Fernando R., Curiel T.J., Grosenbach D.W., Schlom J., Palena C. IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 2007, 110:3192-3201.
-
(2007)
Blood
, vol.110
, pp. 3192-3201
-
-
Litzinger, M.T.1
Fernando, R.2
Curiel, T.J.3
Grosenbach, D.W.4
Schlom, J.5
Palena, C.6
-
58
-
-
0035903324
-
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
-
Sutmuller R.P., van Duivenvoorde L.M., van Elsas A., Schumacher T.N., Wildenberg M.E., Allison J.P., Toes R.E., Offringa R., Melief C.J. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001, 194:823-832.
-
(2001)
J Exp Med
, vol.194
, pp. 823-832
-
-
Sutmuller, R.P.1
van Duivenvoorde, L.M.2
van Elsas, A.3
Schumacher, T.N.4
Wildenberg, M.E.5
Allison, J.P.6
Toes, R.E.7
Offringa, R.8
Melief, C.J.9
-
59
-
-
49649121241
-
Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma
-
Kline J., Brown I.E., Zha Y.Y., Blank C., Strickler J., Wouters H., Zhang L., Gajewski T.F. Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. Clin Cancer Res 2008, 14:3156-3167.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3156-3167
-
-
Kline, J.1
Brown, I.E.2
Zha, Y.Y.3
Blank, C.4
Strickler, J.5
Wouters, H.6
Zhang, L.7
Gajewski, T.F.8
-
60
-
-
0027078670
-
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
-
Chen L., Ashe S., Brady W.A., Hellstrom I., Hellstrom K.E., Ledbetter J.A., McGowan P., Linsley P.S. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 1992, 71:1093-1102.
-
(1992)
Cell
, vol.71
, pp. 1093-1102
-
-
Chen, L.1
Ashe, S.2
Brady, W.A.3
Hellstrom, I.4
Hellstrom, K.E.5
Ledbetter, J.A.6
McGowan, P.7
Linsley, P.S.8
-
61
-
-
0027392843
-
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells [see comments]
-
Townsend S.E., Allison J.P. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells [see comments]. Science 1993, 259:368-370.
-
(1993)
Science
, vol.259
, pp. 368-370
-
-
Townsend, S.E.1
Allison, J.P.2
-
62
-
-
0030584849
-
Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization
-
Gajewski T.F., Fallarino F., Uyttenhove C., Boon T. Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization. J Immunol 1996, 156:2909-2917.
-
(1996)
J Immunol
, vol.156
, pp. 2909-2917
-
-
Gajewski, T.F.1
Fallarino, F.2
Uyttenhove, C.3
Boon, T.4
-
63
-
-
0030763676
-
Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells
-
Fallarino F., Ashikari A., Boon T., Gajewski T.F. Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells. Int Immunol 1997, 9:1259-1269.
-
(1997)
Int Immunol
, vol.9
, pp. 1259-1269
-
-
Fallarino, F.1
Ashikari, A.2
Boon, T.3
Gajewski, T.F.4
-
64
-
-
0028114542
-
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor
-
Boussiotis V.A., Barber D.L., Nakarai T., Freeman G.J., Gribben J.G., Bernstein G.M., D'Andrea A.D., Ritz J., Nadler L.M. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science 1994, 266:1039-1042.
-
(1994)
Science
, vol.266
, pp. 1039-1042
-
-
Boussiotis, V.A.1
Barber, D.L.2
Nakarai, T.3
Freeman, G.J.4
Gribben, J.G.5
Bernstein, G.M.6
D'Andrea, A.D.7
Ritz, J.8
Nadler, L.M.9
-
65
-
-
67349193717
-
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
-
Pellegrini M., Calzascia T., Elford A.R., Shahinian A., Lin A.E., Dissanayake D., Dhanji S., Nguyen L.T., Gronski M.A., Morre M., et al. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 2009, 15:528-536.
-
(2009)
Nat Med
, vol.15
, pp. 528-536
-
-
Pellegrini, M.1
Calzascia, T.2
Elford, A.R.3
Shahinian, A.4
Lin, A.E.5
Dissanayake, D.6
Dhanji, S.7
Nguyen, L.T.8
Gronski, M.A.9
Morre, M.10
-
66
-
-
10744226452
-
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
-
Klebanoff C.A., Finkelstein S.E., Surman D.R., Lichtman M.K., Gattinoni L., Theoret M.R., Grewal N., Spiess P.J., Antony P.A., Palmer D.C., et al. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci U S A 2004, 101:1969-1974.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 1969-1974
-
-
Klebanoff, C.A.1
Finkelstein, S.E.2
Surman, D.R.3
Lichtman, M.K.4
Gattinoni, L.5
Theoret, M.R.6
Grewal, N.7
Spiess, P.J.8
Antony, P.A.9
Palmer, D.C.10
-
67
-
-
42349091974
-
Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells
-
Epardaud M., Elpek K.G., Rubinstein M.P., Yonekura A.R., Bellemare-Pelletier A., Bronson R., Hamerman J.A., Goldrath A.W., Turley S.J. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res 2008, 68:2972-2983.
-
(2008)
Cancer Res
, vol.68
, pp. 2972-2983
-
-
Epardaud, M.1
Elpek, K.G.2
Rubinstein, M.P.3
Yonekura, A.R.4
Bellemare-Pelletier, A.5
Bronson, R.6
Hamerman, J.A.7
Goldrath, A.W.8
Turley, S.J.9
-
68
-
-
25844484607
-
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
-
Gattinoni L., Finkelstein S.E., Klebanoff C.A., Antony P.A., Palmer D.C., Spiess P.J., Hwang L.N., Yu Z., Wrzesinski C., Heimann D.M., et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med 2005, 202:907-912.
-
(2005)
J Exp Med
, vol.202
, pp. 907-912
-
-
Gattinoni, L.1
Finkelstein, S.E.2
Klebanoff, C.A.3
Antony, P.A.4
Palmer, D.C.5
Spiess, P.J.6
Hwang, L.N.7
Yu, Z.8
Wrzesinski, C.9
Heimann, D.M.10
-
69
-
-
28544446699
-
Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing
-
Wang L.X., Li R., Yang G., Lim M., O'Hara A., Chu Y., Fox B.A., Restifo N.P., Urba W.J., Hu H.M. Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing. Cancer Res 2005, 65:10569-10577.
-
(2005)
Cancer Res
, vol.65
, pp. 10569-10577
-
-
Wang, L.X.1
Li, R.2
Yang, G.3
Lim, M.4
O'Hara, A.5
Chu, Y.6
Fox, B.A.7
Restifo, N.P.8
Urba, W.J.9
Hu, H.M.10
-
70
-
-
33749135271
-
Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection
-
Brown I.E., Blank C., Kline J., Kacha A.K., Gajewski T.F. Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. J Immunol 2006, 177:4521-4529.
-
(2006)
J Immunol
, vol.177
, pp. 4521-4529
-
-
Brown, I.E.1
Blank, C.2
Kline, J.3
Kacha, A.K.4
Gajewski, T.F.5
-
71
-
-
84863275160
-
Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation
-
Kline J., Zhang L., Battaglia L., Cohen K.S., Gajewski T.F. Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation. J Immunol 2012, 188:2630-2642.
-
(2012)
J Immunol
, vol.188
, pp. 2630-2642
-
-
Kline, J.1
Zhang, L.2
Battaglia, L.3
Cohen, K.S.4
Gajewski, T.F.5
-
72
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian S.L., Hodi F.S., Brahmer J.R., Gettinger S.N., Smith D.C., McDermott D.F., Powderly J.D., Carvajal R.D., Sosman J.A., Atkins M.B., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012, 366:2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
-
73
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer J.R., Tykodi S.S., Chow L.Q., Hwu W.J., Topalian S.L., Hwu P., Drake C.G., Camacho L.H., Kauh J., Odunsi K., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012, 366:2443-2465.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
-
74
-
-
0002442403
-
DAB(389)IL-2 (denileukin diftitox, ONTAK): review of clinical trials to date
-
Kuzel T.M. DAB(389)IL-2 (denileukin diftitox, ONTAK): review of clinical trials to date. Clin Lymphoma 2000, 1(Suppl. 1):S33-S36.
-
(2000)
Clin Lymphoma
, vol.1
, Issue.SUPPL. 1
-
-
Kuzel, T.M.1
-
75
-
-
42649136634
-
Transient T cell depletion causes regression of melanoma metastases
-
Rasku M.A., Clem A.L., Telang S., Taft B., Gettings K., Gragg H., Cramer D., Lear S.C., McMasters K.M., Miller D.M., et al. Transient T cell depletion causes regression of melanoma metastases. J Transl Med 2008, 6:12.
-
(2008)
J Transl Med
, vol.6
, pp. 12
-
-
Rasku, M.A.1
Clem, A.L.2
Telang, S.3
Taft, B.4
Gettings, K.5
Gragg, H.6
Cramer, D.7
Lear, S.C.8
McMasters, K.M.9
Miller, D.M.10
-
76
-
-
50949115267
-
Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
-
Morse M.A., Hobeika A.C., Osada T., Serra D., Niedzwiecki D., Lyerly H.K., Clay T.M. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood 2008, 112:610-618.
-
(2008)
Blood
, vol.112
, pp. 610-618
-
-
Morse, M.A.1
Hobeika, A.C.2
Osada, T.3
Serra, D.4
Niedzwiecki, D.5
Lyerly, H.K.6
Clay, T.M.7
-
77
-
-
30144444279
-
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
-
Dannull J., Su Z., Rizzieri D., Yang B.K., Coleman D., Yancey D., Zhang A., Dahm P., Chao N., Gilboa E., et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 2005, 115:3623-3633.
-
(2005)
J Clin Invest
, vol.115
, pp. 3623-3633
-
-
Dannull, J.1
Su, Z.2
Rizzieri, D.3
Yang, B.K.4
Coleman, D.5
Yancey, D.6
Zhang, A.7
Dahm, P.8
Chao, N.9
Gilboa, E.10
-
78
-
-
27444435581
-
Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
-
Attia P., Maker A.V., Haworth L.R., Rogers-Freezer L., Rosenberg S.A. Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. J Immunother 2005, 28:582-592.
-
(2005)
J Immunother
, vol.28
, pp. 582-592
-
-
Attia, P.1
Maker, A.V.2
Haworth, L.R.3
Rogers-Freezer, L.4
Rosenberg, S.A.5
-
79
-
-
84861175955
-
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
-
Rech A.J., Mick R., Martin S., Recio A., Aqui N.A., Powell D.J., Colligon T.A., Trosko J.A., Leinbach L.I., Pletcher C.H., et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med 2012, 4:134ra162.
-
(2012)
Sci Transl Med
, vol.4
-
-
Rech, A.J.1
Mick, R.2
Martin, S.3
Recio, A.4
Aqui, N.A.5
Powell, D.J.6
Colligon, T.A.7
Trosko, J.A.8
Leinbach, L.I.9
Pletcher, C.H.10
-
80
-
-
74549117108
-
Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy
-
Sportes C., Babb R.R., Krumlauf M.C., Hakim F.T., Steinberg S.M., Chow C.K., Brown M.R., Fleisher T.A., Noel P., Maric I., et al. Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy. Clin Cancer Res 2010, 16:727-735.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 727-735
-
-
Sportes, C.1
Babb, R.R.2
Krumlauf, M.C.3
Hakim, F.T.4
Steinberg, S.M.5
Chow, C.K.6
Brown, M.R.7
Fleisher, T.A.8
Noel, P.9
Maric, I.10
-
81
-
-
79955418828
-
Harnessing the biology of IL-7 for therapeutic application
-
Mackall C.L., Fry T.J., Gress R.E. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011, 11:330-342.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 330-342
-
-
Mackall, C.L.1
Fry, T.J.2
Gress, R.E.3
-
82
-
-
84855804372
-
Interleukin-15 biology and its therapeutic implications in cancer
-
Steel J.C., Waldmann T.A., Morris J.C. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol Sci 2012, 33:35-41.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 35-41
-
-
Steel, J.C.1
Waldmann, T.A.2
Morris, J.C.3
-
83
-
-
42949139835
-
Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma
-
Thompson J.A., Curti B.D., Redman B.G., Bhatia S., Weber J.S., Agarwala S.S., Sievers E.L., Hughes S.D., DeVries T.A., Hausman D.F. Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J Clin Oncol 2008, 26:2034-2039.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2034-2039
-
-
Thompson, J.A.1
Curti, B.D.2
Redman, B.G.3
Bhatia, S.4
Weber, J.S.5
Agarwala, S.S.6
Sievers, E.L.7
Hughes, S.D.8
DeVries, T.A.9
Hausman, D.F.10
-
84
-
-
84866772544
-
Interleukin-21 has activity in patients with metastatic melanoma: a phase II study
-
Petrella T.M., Tozer R., Belanger K., Savage K.J., Wong R., Smylie M., Kamel-Reid S., Tron V., Chen B.E., Hunder N.N., et al. Interleukin-21 has activity in patients with metastatic melanoma: a phase II study. J Clin Oncol 2012, 30:3396-3401.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3396-3401
-
-
Petrella, T.M.1
Tozer, R.2
Belanger, K.3
Savage, K.J.4
Wong, R.5
Smylie, M.6
Kamel-Reid, S.7
Tron, V.8
Chen, B.E.9
Hunder, N.N.10
-
85
-
-
5144226237
-
Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes
-
Rosenberg S.A., Dudley M.E. Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes. Proc Natl Acad Sci U S A 2004, 101(Suppl. 2):14639-14645.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.SUPPL. 2
, pp. 14639-14645
-
-
Rosenberg, S.A.1
Dudley, M.E.2
-
86
-
-
55949125601
-
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
-
Dudley M.E., Yang J.C., Sherry R., Hughes M.S., Royal R., Kammula U., Robbins P.F., Huang J., Citrin D.E., Leitman S.F., et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008, 26:5233-5239.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5233-5239
-
-
Dudley, M.E.1
Yang, J.C.2
Sherry, R.3
Hughes, M.S.4
Royal, R.5
Kammula, U.6
Robbins, P.F.7
Huang, J.8
Citrin, D.E.9
Leitman, S.F.10
-
87
-
-
36048963838
-
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems
-
Grosso J.F., Kelleher C.C., Harris T.J., Maris C.H., Hipkiss E.L., De Marzo A., Anders R., Netto G., Getnet D., Bruno T.C., et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. J Clin Invest 2007, 117:3383-3392.
-
(2007)
J Clin Invest
, vol.117
, pp. 3383-3392
-
-
Grosso, J.F.1
Kelleher, C.C.2
Harris, T.J.3
Maris, C.H.4
Hipkiss, E.L.5
De Marzo, A.6
Anders, R.7
Netto, G.8
Getnet, D.9
Bruno, T.C.10
-
88
-
-
77952343328
-
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
-
Matsuzaki J., Gnjatic S., Mhawech-Fauceglia P., Beck A., Miller A., Tsuji T., Eppolito C., Qian F., Lele S., Shrikant P., et al. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A 2010, 107:7875-7880.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7875-7880
-
-
Matsuzaki, J.1
Gnjatic, S.2
Mhawech-Fauceglia, P.3
Beck, A.4
Miller, A.5
Tsuji, T.6
Eppolito, C.7
Qian, F.8
Lele, S.9
Shrikant, P.10
-
89
-
-
77957723967
-
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
-
Fourcade J., Sun Z., Benallaoua M., Guillaume P., Luescher I.F., Sander C., Kirkwood J.M., Kuchroo V., Zarour H.M. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med 2010, 207:2175-2186.
-
(2010)
J Exp Med
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Benallaoua, M.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
Kirkwood, J.M.7
Kuchroo, V.8
Zarour, H.M.9
-
90
-
-
77957744369
-
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
Sakuishi K., Apetoh L., Sullivan J.M., Blazar B.R., Kuchroo V.K., Anderson A.C. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010, 207:2187-2194.
-
(2010)
J Exp Med
, vol.207
, pp. 2187-2194
-
-
Sakuishi, K.1
Apetoh, L.2
Sullivan, J.M.3
Blazar, B.R.4
Kuchroo, V.K.5
Anderson, A.C.6
-
91
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
Woo S.R., Turnis M.E., Goldberg M.V., Bankoti J., Selby M., Nirschl C.J., Bettini M.L., Gravano D.M., Vogel P., Liu C.L., et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012, 72:917-927.
-
(2012)
Cancer Res
, vol.72
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
Bankoti, J.4
Selby, M.5
Nirschl, C.J.6
Bettini, M.L.7
Gravano, D.M.8
Vogel, P.9
Liu, C.L.10
-
92
-
-
79959808002
-
Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways
-
Wang S., Chen L. Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways. Curr Top Microbiol Immunol 2011, 344:245-267.
-
(2011)
Curr Top Microbiol Immunol
, vol.344
, pp. 245-267
-
-
Wang, S.1
Chen, L.2
-
93
-
-
0035397980
-
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
-
Sievers E.L., Larson R.A., Stadtmauer E.A., Estey E., Lowenberg B., Dombret H., Karanes C., Theobald M., Bennett J.M., Sherman M.L., et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol 2001, 19:3244-3254.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3244-3254
-
-
Sievers, E.L.1
Larson, R.A.2
Stadtmauer, E.A.3
Estey, E.4
Lowenberg, B.5
Dombret, H.6
Karanes, C.7
Theobald, M.8
Bennett, J.M.9
Sherman, M.L.10
-
94
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S., Miles D., Gianni L., Krop I.E., Welslau M., Baselga J., Pegram M., Oh D.Y., Dieras V., Guardino E., et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012, 367:1783-1791.
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
Krop, I.E.4
Welslau, M.5
Baselga, J.6
Pegram, M.7
Oh, D.Y.8
Dieras, V.9
Guardino, E.10
-
95
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J., Costes A., Sanchez-Cabo F., Kirilovsky A., Mlecnik B., Lagorce-Pages C., Tosolini M., Camus M., Berger A., Wind P., et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006, 313:1960-1964.
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
Tosolini, M.7
Camus, M.8
Berger, A.9
Wind, P.10
-
96
-
-
84855225492
-
The immune score as a new possible approach for the classification of cancer
-
Galon J., Pages F., Marincola F.M., Thurin M., Trinchieri G., Fox B.A., Gajewski T.F., Ascierto P.A. The immune score as a new possible approach for the classification of cancer. J Transl Med 2012, 10:1.
-
(2012)
J Transl Med
, vol.10
, pp. 1
-
-
Galon, J.1
Pages, F.2
Marincola, F.M.3
Thurin, M.4
Trinchieri, G.5
Fox, B.A.6
Gajewski, T.F.7
Ascierto, P.A.8
-
97
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi F.S., O'Day S.J., McDermott D.F., Weber R.W., Sosman J.A., Haanen J.B., Gonzalez R., Robert C., Schadendorf D., Hassel J.C., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010.
-
(2010)
N Engl J Med
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
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