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Volumn 117, Issue 4, 2005, Pages 538-550

CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction

Author keywords

Apoptosis; CTLA 4; Ligands; Tumors

Indexed keywords

CASPASE 3; CASPASE 8; CD86 ANTIGEN; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LIGAND; RNA;

EID: 27144458821     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21155     Document Type: Article
Times cited : (258)

References (50)
  • 3
    • 0031861620 scopus 로고    scopus 로고
    • Negative regulation of T cell activation
    • Saito T. Negative regulation of T cell activation. Curr Opin Immunol 1998;10:313-21.
    • (1998) Curr Opin Immunol , vol.10 , pp. 313-321
    • Saito, T.1
  • 4
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Kummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996;183:2533-40.
    • (1996) J Exp Med , vol.183 , pp. 2533-2540
    • Kummel, M.F.1    Allison, J.P.2
  • 5
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001;19:565-94.
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3    Allison, J.P.4
  • 7
    • 0037244012 scopus 로고    scopus 로고
    • Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4
    • Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2003;197:129-35.
    • (2003) J Exp Med , vol.197 , pp. 129-135
    • Chikuma, S.1    Imboden, J.B.2    Bluestone, J.A.3
  • 9
    • 0037131969 scopus 로고    scopus 로고
    • Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    • Levings MK, Sangregorio R, Sartirana C, Moschin AL, Battaglia M, Orban PC, Roncarolo MG. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med 2002;196:1335-46.
    • (2002) J Exp Med , vol.196 , pp. 1335-1346
    • Levings, M.K.1    Sangregorio, R.2    Sartirana, C.3    Moschin, A.L.4    Battaglia, M.5    Orban, P.C.6    Roncarolo, M.G.7
  • 10
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192:303-10.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6    Mak, T.W.7    Sakaguchi, S.8
  • 16
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003;3:807-21.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 17
    • 0034880059 scopus 로고    scopus 로고
    • Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity
    • Seo N, Hayakawa S, Takigawa M, Tokura Y. Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity. Immunology 2001;103:449-57.
    • (2001) Immunology , vol.103 , pp. 449-457
    • Seo, N.1    Hayakawa, S.2    Takigawa, M.3    Tokura, Y.4
  • 20
    • 0032479141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumor immune response using a combination of interferon-gamma and B7 expression in an experimental mammary carcinoma
    • Hurwitz AA, Townsend SE, Yu TF, Wallin JA, Allison JP. Enhancement of the anti-tumor immune response using a combination of interferon-gamma and B7 expression in an experimental mammary carcinoma. Int J Cancer 1998;77:107-13.
    • (1998) Int J Cancer , vol.77 , pp. 107-113
    • Hurwitz, A.A.1    Townsend, S.E.2    Yu, T.F.3    Wallin, J.A.4    Allison, J.P.5
  • 22
  • 23
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 24
    • 0032404099 scopus 로고    scopus 로고
    • Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice
    • Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res 1998;58:5301-4.
    • (1998) Cancer Res , vol.58 , pp. 5301-5304
    • Mokyr, M.B.1    Kalinichenko, T.2    Gorelik, L.3    Bluestone, J.A.4
  • 25
    • 0342632802 scopus 로고    scopus 로고
    • Vaccination with mouse mammary adenocarcinoma cells coexpressing B7-1 (CD80) and B7-2 (CD86) discloses the dominant effect of B7-1 in the induction of antitumor immunity
    • Martin-Fontecha A, Moro M, Crosti MC, Veglia F, Casorati G, Dellabona P. Vaccination with mouse mammary adenocarcinoma cells coexpressing B7-1 (CD80) and B7-2 (CD86) discloses the dominant effect of B7-1 in the induction of antitumor immunity. J Immunol 2000;164:698-704.
    • (2000) J Immunol , vol.164 , pp. 698-704
    • Martin-Fontecha, A.1    Moro, M.2    Crosti, M.C.3    Veglia, F.4    Casorati, G.5    Dellabona, P.6
  • 27
    • 0037413950 scopus 로고    scopus 로고
    • Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules
    • Briones J, Timmerman JM, Panicalli DL, Levy R. Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules. J Natl Cancer Inst 2003;95:548-55.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 548-555
    • Briones, J.1    Timmerman, J.M.2    Panicalli, D.L.3    Levy, R.4
  • 32
    • 0024205313 scopus 로고
    • Human Ig superfamily CTLA-4 gene: Chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
    • Dariavach P, Mattei MG, Golstein P, Lefranc MP. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur J Immunol 1988;18:1901-5.
    • (1988) Eur J Immunol , vol.18 , pp. 1901-1905
    • Dariavach, P.1    Mattei, M.G.2    Golstein, P.3    Lefranc, M.P.4
  • 33
    • 0027057908 scopus 로고
    • CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production
    • Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol 1992;149:3795-801.
    • (1992) J Immunol , vol.149 , pp. 3795-3801
    • Freeman, G.J.1    Lombard, D.B.2    Gimmi, C.D.3    Brod, S.A.4    Lee, K.5    Laning, J.C.6    Hafler, D.A.7    Dorf, M.E.8    Gray, G.S.9    Reiser, H.10
  • 34
    • 0033567050 scopus 로고    scopus 로고
    • Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
    • Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, Rudd CE. Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol 1999;163:1868-79.
    • (1999) J Immunol , vol.163 , pp. 1868-1879
    • Schneider, H.1    Martin, M.2    Agarraberes, F.A.3    Yin, L.4    Rapoport, I.5    Kirchhausen, T.6    Rudd, C.E.7
  • 35
    • 0030176371 scopus 로고    scopus 로고
    • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
    • Linsley PS, Bradshaw J, Greene J, Peach R, Bennett KL, Mittler RS. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996;4:535-43.
    • (1996) Immunity , vol.4 , pp. 535-543
    • Linsley, P.S.1    Bradshaw, J.2    Greene, J.3    Peach, R.4    Bennett, K.L.5    Mittler, R.S.6
  • 36
    • 84990622726 scopus 로고
    • Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers
    • Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987;20:263-72.
    • (1987) Cell Tissue Kinet , vol.20 , pp. 263-272
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Gerasimov, U.V.3
  • 37
    • 0029787806 scopus 로고    scopus 로고
    • Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro
    • Cassiede P, Dennis JE, Ma F, Caplan AI. Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res 1996;11:1264-73.
    • (1996) J Bone Miner Res , vol.11 , pp. 1264-1273
    • Cassiede, P.1    Dennis, J.E.2    Ma, F.3    Caplan, A.I.4
  • 39
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 1997;64:295-312.
    • (1997) J Cell Biochem , vol.64 , pp. 295-312
    • Jaiswal, N.1    Haynesworth, S.E.2    Caplan, A.I.3    Bruder, S.P.4
  • 41
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994;1:793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 42
    • 0030028248 scopus 로고    scopus 로고
    • B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity: Further evidence that B7-1 and B7-2 are functionally distinct
    • Matulonis U, Dosiou C, Freeman G, Lamont C, Mauch P, Nadler LM, Griffin JD. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity: further evidence that B7-1 and B7-2 are functionally distinct. J Immunol 1996;156:1126-31.
    • (1996) J Immunol , vol.156 , pp. 1126-1131
    • Matulonis, U.1    Dosiou, C.2    Freeman, G.3    Lamont, C.4    Mauch, P.5    Nadler, L.M.6    Griffin, J.D.7
  • 43
    • 2942753760 scopus 로고    scopus 로고
    • Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes
    • Martelli AM, Cappellini A, Tazzari PL, Billi AM, Tassi C, Ricci F, Fala F, Conte R. Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes. Haematologica 2001;89:471-9.
    • (2001) Haematologica , vol.89 , pp. 471-479
    • Martelli, A.M.1    Cappellini, A.2    Tazzari, P.L.3    Billi, A.M.4    Tassi, C.5    Ricci, F.6    Fala, F.7    Conte, R.8
  • 44
    • 0037779101 scopus 로고    scopus 로고
    • Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L
    • Airoldi I, Lualdi S, Bruno S, Raffaghello L, Occhino M, Gambini C, Pistoia V, Corrias MV. Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L. Br J Cancer 2003;88:1527-36.
    • (2003) Br J Cancer , vol.88 , pp. 1527-1536
    • Airoldi, I.1    Lualdi, S.2    Bruno, S.3    Raffaghello, L.4    Occhino, M.5    Gambini, C.6    Pistoia, V.7    Corrias, M.V.8
  • 46
    • 0034922907 scopus 로고    scopus 로고
    • Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules
    • Villinger F, Bostik P, Mayne A, King CL, Genain CP, Weiss WR, Ansari AA. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Immunogenetics 2001;53:315-28.
    • (2001) Immunogenetics , vol.53 , pp. 315-328
    • Villinger, F.1    Bostik, P.2    Mayne, A.3    King, C.L.4    Genain, C.P.5    Weiss, W.R.6    Ansari, A.A.7
  • 48
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel MF, Allison PJ. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996;183:2533-40.
    • (1996) J Exp Med , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, P.J.2
  • 49
    • 0032543987 scopus 로고    scopus 로고
    • Fas-independent death of activated CD4+ T lymphocytes induced by CTLA-4 crosslinking
    • Scheipers P, Reiser H. Fas-independent death of activated CD4+ T lymphocytes induced by CTLA-4 crosslinking. Proc Natl Acad Sci USA 1998;95:10083-8.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10083-10088
    • Scheipers, P.1    Reiser, H.2
  • 50
    • 0038393124 scopus 로고    scopus 로고
    • The death effector domain protein family: Regulators of cellular homeostasis
    • Tibbetts MD, Zheng L, Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat Immunol 2003;4:404-9.
    • (2003) Nat Immunol , vol.4 , pp. 404-409
    • Tibbetts, M.D.1    Zheng, L.2    Lenardo, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.