Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor

Journal of Medicinal Chemistry

Volumn 57, Issue 19, 2014, Pages 8167-8179

  Brus, Boris ^a   Košak, Urban ^a   Turk, Samo ^a   Pišlar, Anja ^a   Coquelle, Nicolas ^b,c   Kos, Janko ^a,d   Stojan, Jure ^a   Colletier, Jacques Philippe ^b,c   Gobec, Stanislav ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c CEA GRENOBLE   (France)

^d JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; PROTEIN AGGREGATION; RACEMIC MIXTURE; STEREOISOMERISM; ANIMAL; CHEMISTRY; CRYSTALLIZATION; DRUG DEVELOPMENT; MOLECULAR DOCKING; MOUSE; SYNTHESIS; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANIMALS; BUTYRYLCHOLINESTERASE; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG DISCOVERY; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; STEREOISOMERISM;

EID: 84907897613     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501195e     Document Type: Article

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