Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 47, 2005, Pages 17213-17218

  Greig, Nigel H ^a   Utsuki, Tadanobu ^a,c   Ingram, Donald K ^a   Wang, Yue ^a   Pepeu, Giancarlo ^b   Scali, Carla ^b   Yu, Qian Sheng ^a   Mamczarz, Jacek ^a   Holloway, Harold W ^a   Giordano, Tony ^c   Chen, Demao ^f   Furukawa, Katsutoshi ^a   Sambamurti, Kumar ^d   Brossi, Arnold ^e   Lahiri, Debomoy K ^f  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF FLORENCE   (Italy)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anticholinesterase; Dementia; Long term potentiation; Memory; Neurodegeneration

Indexed keywords

1N PHENETHYLNORCYMSERINE; 1N,8N BISNORCYMSERINE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CYMSERINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; COGNITION; CONTROLLED STUDY; DEMENTIA; DRUG POTENCY; ENZYME INHIBITION; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; MOUSE; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRANSGENIC MOUSE;

ACETYLCHOLINE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HUMANS; LEARNING; MALE; MICE; MICE, TRANSGENIC; NEUROBLASTOMA; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SERINE; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 28044437122     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508575102     Document Type: Article

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