Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 16, 2014, Pages 7073-7084

  Hamulakova, Slavka ^a   Janovec, Ladislav ^a   Hrabinova, Martina ^b   Spilovska, Katarina ^a,d   Korabecny, Jan ^c,d   Kristian, Pavol ^a   Kuca, Kamil ^b,c   Imrich, Jan ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^d UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN; COUMARIN DERIVATIVE; TACRINE;

CHEMISTRY; DRUG SCREENING; HUMAN; IC50; METABOLISM; MOLECULAR DOCKING; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; COUMARINS; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84906888262     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5008648     Document Type: Article

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