Novel 18F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in alzheimers disease

Journal of Medicinal Chemistry

Volumn 55, Issue 21, 2012, Pages 9136-9145

  Cui, Mengchao ^a,b   Ono, Masahiro ^a   Kimura, Hiroyuki ^a   Ueda, Masashi ^a   Nakamoto, Yuji ^a   Togashi, Kaori ^a   Okamoto, Yoko ^a   Ihara, Masafumi ^a   Takahashi, Ryosuke ^a   Liu, Boli ^b   Saji, Hideo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 [2 [2 (2 FLUOROETHOXY)ETHOXY]ETHOXYBENZO[D]OXAZOL 2 YL] N METHYLANILINE F 18; 4 [5 [2 [2 (2 FLUOROETHOXY)ETHOXY]ETHOXYBENZO[D]OXAZOL 2 YL] N,N DIMETHYLANILINE F 18; AMYLOID BETA PROTEIN[1-42]; BENZOXAZOLE DERIVATIVE; FLUORINE 18; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); FLUORINE; PEPTIDE FRAGMENT; RADIOPHARMACEUTICAL AGENT;

AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; REACTION ANALYSIS; STRUCTURE ANALYSIS; ANIMAL; BRAIN; C57BL MOUSE; CHEMISTRY; METABOLISM; RADIOASSAY; SCINTISCANNING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PEPTIDES; ANIMALS; BENZOXAZOLES; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 84868593540     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300251n     Document Type: Article

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