Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 661-669

  Galdeano, Carles ^a   Viayna, Elisabet ^a   Sola, Irene ^a   Formosa, Xavier ^a   Camps, Pelayo ^a   Badia, Albert ^b   Clos, M Victòria ^b   Relat, Júlia ^b   Ratia, Míriam ^b   Bartolini, Manuela ^c   Mancini, Francesca ^c   Andrisano, Vincenza ^c   Salmona, Mario ^d   Minguillón, Cristina ^a   González Muñoz, Gema C ^e   Rodríguez Franco, M Isabel ^e   Bidon Chanal, Axel ^a   Luque, F Javier ^a   Muñoz Torrero, Diego ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; BETA SECRETASE; CHOLINESTERASE; HUPRINE TACRINE HETERODIMER; NOOTROPIC AGENT; PRION PROTEIN; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CATALYSIS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PENETRATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRION DISEASE; PROTEIN AGGREGATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOQUINOLINES; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MEMBRANES, ARTIFICIAL; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PERMEABILITY; PRION DISEASES; PRIONS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84856378492     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200840c     Document Type: Article

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