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Biochemistry

Volumn 41, Issue 11, 2002, Pages 3555-3564

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

(7) Bar On, P a Millard, C B a,b Harel, M a Dvir, H a Enz, A c Sussman, J L a Silman, I a

a WEIZMANN INSTITUTE OF SCIENCE (Israel)

b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES (United States)

c NOVARTIS PHARMA AG (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVATION;

CRYSTAL STRUCTURE; DISEASES; DRUG PRODUCTS; ENZYME INHIBITION; HYDROGEN BONDS; PATIENT TREATMENT; RATE CONSTANTS;

ENZYMES;

CHOLINESTERASE; CHOLINESTERASE INHIBITOR; HISTIDINE; RIVASTIGMINE;

ALZHEIMER DISEASE; ARTICLE; CARBAMOYLATION; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; KINETICS; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TORPEDO CALIFORNICA;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CARBAMATES; CHOLINESTERASE INHIBITORS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; KINETICS; NEUROPROTECTIVE AGENTS; PHENYLCARBAMATES; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; TORPEDO;

DROSOPHILA MELANOGASTER; MELANOGASTER; TORPEDO; TORPEDO CALIFORNICA;

EID: 0037133519 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi020016x Document Type: Article

Times cited : (324)

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