The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 Cells

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Impheng, Hathaichanok ^a   Pongcharoen, Sutatip ^a   Richert, Lysiane ^b   Pekthong, Dumrongsak ^a   Srisawang, Piyarat ^a  

^a NARESUAN UNIVERSITY   (Thailand)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CAPSAICIN; CARNITINE PALMITOYLTRANSFERASE I; CERAMIDE; FATTY ACID; FATTY ACID SYNTHASE; MALONYL COENZYME A; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; ANTINEOPLASTIC AGENT; CITRIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIPID STORAGE; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN TARGETING; BIOSYNTHESIS; CELL CYCLE; CELL NUCLEUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; INTRACELLULAR SPACE; METABOLISM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CAPSAICIN; CELL CYCLE; CELL NUCLEUS; CELL SURVIVAL; CITRATES; FATTY ACID SYNTHASES; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HUMANS; INTRACELLULAR SPACE; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; TRIGLYCERIDES;

EID: 84907459386     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107842     Document Type: Article

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