Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 247-255

  Pekthong, Dumrongsak ^a   Blanchard, Nadège ^b   Abadie, Catherine ^b   Bonet, Alexandre ^a   Heyd, Bruno ^c   Mantion, Georges ^c   Berthelot, Alain ^a   Richert, Lysiane ^a,b   Martin, Hélène ^a  

^a France   (France)

^b KaLy Cell   (France)

^c UNIVERSITY HOSPITAL OF BESANÇON   (France)

Author keywords

Andrographis paniculata; Andrographolide; Cytochrome P450; Hepatocyte; Inhibition

Indexed keywords

ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; MESSENGER RNA; UNSPECIFIC MONOOXYGENASE;

ADULT; AGED; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT;

ADMINISTRATION, ORAL; AGED; ANDROGRAPHIS; ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; LIVER; MALE; MIXED FUNCTION OXYGENASES; PLANT EXTRACTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

ANDROGRAPHIS PANICULATA; RATTUS;

EID: 62749197576     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.054     Document Type: Article

References (35)

1. Kelly J.P., Kaufman D.W., Kelley K., Rosenberg L., Anderson T.E., and Mitchell A.A. Recent trends in use of herbal and other natural products. Arch. Intern. Med. 165 (2005) 281-286
2. Brazier N.C., and Levine M.A.H. Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals. Am. J. Therapeut. 10 (2003) 163-169
3. Moschella C., and Jaber B.L. Interaction between cyclosporine and Hypericum perforatum (St John's wort) after organ transplantation. Am. J. Kidn. Dis. 38 (2001) 1105-1107
4. Schwarz U.I., Buschel B., and Kirch W. Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Br. J. Clin. Pharmacol. 55 (2003) 112-113
5. Gaudineau C., Beckerman R., Welbourn S., and Auclair K. Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochem. Biophys. Res. Commun. 318 (2004) 1072-1078
6. Coon M.J. Cytochrome P450: nature's most versatile biological catalyst. Ann. Rev. Pharmacol. Toxicol. 45 (2005) 1-25
7. Nebert D.W., Nelson D.R., Coon M.J., Estabrook R.W., Feyereisen R., Fujii-Kuriyama Y., Gonzalez F.J., Guengerich F.P., Gunsalus I.C., Johnson E.F., Loper J.C., Sato R., Waterman M.R., and Waxman D.J. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol. 10 (1991) 397-398
8. Komoroski B.J., Zhang S., Cai H., Hutzler J.M., Frye R., Tracy T.S., Strom S.C., Lehmann T., Ang C.Y., Cui Y.Y., and Venkataramanan R. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab. Dispos. 32 (2004) 512-518
9. Caceres D.D., Hancke J.L., Burgos R.A., and Wikman G.K. Prevention of common colds with Andrographis paniculata dried extract: a pilot double-blind trial. Phytomedicine 4 (1997) 101-104
10. Sheeja K., Shihab P.K., and Kuttan G. Antioxidant and anti-inflammatory activities of the plant Andrographis paniculata Nees. Immunopharmacol. Immunotoxicol. 28 (2006) 129-140
11. Cheung H.Y., Cheung S.H., Li J., Cheung C.S., Lai W.P., Fong W.F., and Leung F.M. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Medica 71 (2005) 1106-1111
12. Iruretagoneya M.I., Tobar J.A., Gonzalez P.A., Sepulveda S.E., Figueroa C.A., Burgos R.A., Hancke J.L., and Kalergis A.M. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J. Pharmacol. Exp. Ther. 312 (2005) 366-372
13. Calabrese C., Merman S.H., Babish J.G., Ma X., Shinto L., Dorr M., Wells K., Wenner C.A., and Standish L.J. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother. Res. 14 (2000) 333-338
14. Pekthong D., Martin H., Abadie C., Bonet A., Heyd B., Mantion G., and Richert L. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and Andrographolide. J. Ethnopharmacol. 115 (2008) 432-440
15. Choudhury B.R., Haque S.J., and Poddar M.K. In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and Andrographolide on hepatic microsomal drug metabolizing enzymes. Planta Medica 53 (1987) 135-140
16. Jarukamjorn K., Don-In K., Makejaruskul C., Laha T., Daodee S., Pearaksa P., and Sripanidkulchai B.O. Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes. J. Ethnopharmacol. 24 (2006) 464-467
17. Jaruchotikamol A., Jarukamjorn K., Sirisangtrakul W., Sakuma T., Kawasaki Y., and Nemoto N. Strong synergistic of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes. Toxicol. Appl. Pharmacol. 224 (2007) 156-162
18. Fujii-Kuriyama Y. Drug-inducible P-450s. In: Omura T., Ishimura Y., and Fujii-Kuriyama Y. (Eds). Cytochrome P-450 (1993), Kodonsha, Tokyo 224-230
19. Jain D.C., Gupta M.M., Saxena S., and Kumar S. LC analysis of hepatoprotective diterpenoids from Andrographis paniculata. J. Pharm. Biomed. Anal. 22 (2000) 705-709
20. Richert L., Binda D., Hamilton G., Abadie C.V., Alexandre E., Bigot D.L., Bars R., Coasso P., and LeCluyse E. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicol. In Vitro 16 (2002) 89-99
21. Richert L., Alexandre E., Lloyd T., Orr S., Viollon-Abadie C., Patel R., Kingston S., Berry D., Dennison A., Heyd B., Mantion G., and Jaeck D. Tissue collection, transport and isolation procedures required to optimize human hepatocyte isolation from waste liver surgical resections. A multilaboratory study. Liver. Int. 24 (2004) 371-378
22. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., and Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47 (1987) 936-942
23. Burke M.D., Thomson S., Elcombe C.R., Halpert J., Haaparanta T., and Mayer R.T. Ethoxy-, penthoxy- and benzyloxy-phenoxasones and homologues: a series of substrate to distinguish between different induced cytochrome P450. Biochem. Pharmacol. 34 (1985) 3337-3345
24. Relling M.V., Aoyama T., Gonzalez F.T., and Meyer U.A. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J. Pharmacol. Exp. Ther. 252 (1990) 442-447
25. Allis J.W., and Robinson B.L. A kinetic assay for p-nitrophenol hydroxylase in rat liver microsomes. Anal. Biochem. 219 (1994) 49-52
26. Pearce R.E., McIntyre C.J., Madan A., Sanzgiri U., Draper A.J., Bullock P.L., Cook D.C., Burton L.A., Latham J., Nevins C., and Parkinson A. Effect of freezing, thawing and storing human liver microsome on cytochrome P450 activity. Arch. Biochem. Biophys. 331 (1996) 145-169
27. Delgoda R., and Westlake A.C. Herbal interactions involving cytochrome p450 enzymes: a mini review. Toxicol. Rev. 23 (2004) 239-249
28. Panossian A., Hovhannisyan A., Mamikonyan G., Abrahamian H., Hambardzumyan E., Gabrielian E., Goukasova G., Wikman G., and Wagner H. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 7 (2000) 351-364
29. Hovhannisyan A.S., Abrahamyan H., Gabrielyan E.S., and Panossian A.G. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of Warfarin in rats. Phytomedicine 13 (2006) 318-323
30. Silva J.M., Morin P.E., Day S.H., Kennedy B.P., Payette P., Rushmore T., Yergey J.A., and Nicoll-Griffith D.A. Refinement of an in vitro cell model for cytochrome P450 induction. Drug Metab. Dispos. 26 (1998) 490-496
31. Goodsaid F.M., Palamanda J.R., Montgomery D., Mandakas G., Gu C., Li Z., You X., Norton L., Smith R., Chu I., Soares T., Alton K., Kishnani N.S., and Rosenblum I.Y. Assessment of temporal biochemical and gene transcription change in rat liver cytochrome P450: utility of real-time quantitative RT-PCR. Pharm. Res. 20 (2003) 1373-1380
32. Cupp M.J., and Tracy T.S. Cytochrome P450: new nomenclature and clinical implications. Am. Fam. Physician 57 (1998) 107-116
33. Rendic S., and Di Carlo F.J. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 29 (1997) 413-580
34. Goldstein J.A. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br. J. Clin. Pharmacol. 52 (2001) 349-355
35. Rettie A.E., Korzekwa K.R., Kunze K.L., Lawrence R.F., Eddy A.C., Aoyama T., Gelboin H.V., Gonzalez F.J., and Trager W.F. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem. Res. Toxicol. 5 (1992) 54-59