4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppressesthe mitochondrial fatty acid synthesis pathway and impairs mitochondrial function

Journal of Biological Chemistry

Volumn 289, Issue 24, 2014, Pages 17184-17194

  Chen, Cong ^a   Han, Xiao ^a   Zou, Xuan ^a   Li, Yuan ^a   Yang, Liang ^a   Cao, Ke ^a   Xu, Jie ^a   Long, Jiangang ^a   Liu, Jiankang ^a   Feng, Zhihui ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DISEASES;

CATALYTIC DOMAINS; CELLULAR PROTECTION; FATTY ACID SYNTHESIS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; PROTECTIVE EFFECTS; REACTIVE OXYGEN SPECIES; THERAPEUTIC EFFECTS;

FATTY ACIDS;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 4 METHYLENE 2 OCTYL 5 OXOTETRAHYDROFURAN 3 CARBOXYLIC ACID; FATTY ACID; FATTY ACID SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENZYME BINDING; FATTY ACID SYNTHESIS; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIOXIDANT; FATTY-ACID SYNTHASE (FAS); MITOCHONDRIA; MITOCHONDRIAL DISEASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES (ROS);

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; 4-BUTYROLACTONE; CELL SURVIVAL; ENZYME INHIBITORS; FATTY ACID SYNTHASE, TYPE I; HEK293 CELLS; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; THIOCTIC ACID;

EID: 84902477323     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.550806     Document Type: Article

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