Capsaicin induces apoptosis in SCC-4 human tongue cancer cells through mitochondria-dependent and -independent pathways

Environmental Toxicology

Volumn 27, Issue 6, 2012, Pages 332-341

  Ip, Siu Wan ^a   Lan, Sheng Hui ^a   Huang, An Cheng ^b   Yang, Jai Sing ^a   Chen, Ya Yin ^a,c   Huang, Hui Ying ^a   Lin, Zen Pin ^d   Hsu, Yuan Man ^a   Yang, Mei Due ^c   Chiu, Chang Fang ^a,c   Chung, Jing Gung ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b St Mary's Medicine Nursing and Management College   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d MINGDAO UNIVERSITY   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Capsaicin; Caspases 3; Human tongue SCC 4 cells; Mitochondria

Indexed keywords

ANTITUMOR EFFECT; CAPSAICIN; CASPASE-3; CASPASES-3; CHILI PEPPER; CONFOCAL LASER MICROSCOPES; CURE RATE; DNA CONTENT; DNA FRAGMENTATION; DOSE-DEPENDENT MANNER; HUMAN CANCER CELLS; HUMAN TONGUE; MOLECULAR MECHANISM; PHASE ARREST; REACTIVE OXYGEN SPECIES; TONGUE CANCER; VIABLE CELLS;

CHEMOTHERAPY; DISEASES; DRUG PRODUCTS; MITOCHONDRIA;

CELL DEATH;

ACTIVATING TRANSCRIPTION FACTOR 4; CAPSAICIN; CASPASE 3; CASPASE 9; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CANCER; CHEMICAL COMPOUND; DISEASE TREATMENT; ENZYME ACTIVITY; MITOCHONDRION; MOLECULAR ANALYSIS; PUBLIC HEALTH; TUMOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DAMAGE; DNA FRAGMENTATION; DOSE RESPONSE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TONGUE CANCER;

APOPTOSIS; CALCIUM; CAPSAICIN; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; TONGUE NEOPLASMS; TUMOR CELLS, CULTURED;

CAPSICUM FRUTESCENS;

EID: 84860619433     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20646     Document Type: Article

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