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Volumn 27, Issue 5, 2013, Pages 713-720

Fatty acid synthase inhibition by amentoflavone suppresses HER2/neu (erbB2) oncogene in SKBR3 human breast cancer cells

Author keywords

amentoflavone; breast cancer; fatty acid synthase; HER2 neu

Indexed keywords

AMENTOFLAVONE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PALMITIC ACID; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR PEA3;

EID: 84876462441     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4778     Document Type: Article
Times cited : (65)

References (34)
  • 1
    • 33745576142 scopus 로고    scopus 로고
    • Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas
    • Alò PL, Visca P, Trombetta G, et al,. 1999. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori 85: 35-40.
    • (1999) Tumori , vol.85 , pp. 35-40
    • Alò, P.L.1    Visca, P.2    Trombetta, G.3
  • 3
    • 36849074161 scopus 로고    scopus 로고
    • Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation
    • Chiang CT, Way TD, Tsai SJ, et al,. 2007. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett 581: 5735-5742.
    • (2007) FEBS Lett , vol.581 , pp. 5735-5742
    • Chiang, C.T.1    Way, T.D.2    Tsai, S.J.3
  • 4
    • 34249897527 scopus 로고    scopus 로고
    • Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL/6 mice
    • Guruvayoorappan C, Kuttan G,. 2007. Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Integr Cancer Ther 6: 185-197.
    • (2007) Integr Cancer Ther , vol.6 , pp. 185-197
    • Guruvayoorappan, C.1    Kuttan, G.2
  • 5
    • 56749184013 scopus 로고    scopus 로고
    • Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages
    • Guruvayoorappan C, Kuttan G,. 2008a. Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. J Exp Ther Oncol 7: 207-218.
    • (2008) J Exp Ther Oncol , vol.7 , pp. 207-218
    • Guruvayoorappan, C.1    Kuttan, G.2
  • 6
    • 54949091958 scopus 로고    scopus 로고
    • Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and cytokines in lung tissues of C57BL/6 mice
    • Guruvayoorappan C, Kuttan G,. 2008b. Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and cytokines in lung tissues of C57BL/6 mice. Immunopharmacol Immunotoxicol 30: 711-727.
    • (2008) Immunopharmacol Immunotoxicol , vol.30 , pp. 711-727
    • Guruvayoorappan, C.1    Kuttan, G.2
  • 7
    • 40649110574 scopus 로고    scopus 로고
    • Inhibition of tumor specific angiogenesis by amentoflavone
    • Guruvayoorappan C, Kuttan G,. 2008c. Inhibition of tumor specific angiogenesis by amentoflavone. Biochemistry (Mosc) 73: 209-218.
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 209-218
    • Guruvayoorappan, C.1    Kuttan, G.2
  • 8
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • Kuhajda FP,. 2002. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 66: 5977-5980.
    • (2002) Cancer Res , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 9
    • 0037226462 scopus 로고    scopus 로고
    • Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
    • Kumar-Sinha C, Ignatoski KW, Lippman ME, et al,. 2003. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res 63: 132-139.
    • (2003) Cancer Res , vol.63 , pp. 132-139
    • Kumar-Sinha, C.1    Ignatoski, K.W.2    Lippman, M.E.3
  • 10
    • 69149106050 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells
    • Lee JS, Lee MS, Oh WK, et al,. 2009. Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells. Biol Pharm Bull 32: 1427-1232.
    • (2009) Biol Pharm Bull , vol.32 , pp. 1427-1232
    • Lee, J.S.1    Lee, M.S.2    Oh, W.K.3
  • 11
    • 33644697200 scopus 로고    scopus 로고
    • Architecture of mammalian fatty acid synthase at 4.5 A resolution
    • Maier T, Jenni S, Ban N,. 2006. Architecture of mammalian fatty acid synthase at 4.5 A resolution. Science 311: 1258-1262.
    • (2006) Science , vol.311 , pp. 1258-1262
    • Maier, T.1    Jenni, S.2    Ban, N.3
  • 12
    • 0242624620 scopus 로고    scopus 로고
    • Biologic and therapeutic role of HER2 in cancer
    • Ménard S, Pupa SM, Campiglio M, et al,. 2003. Biologic and therapeutic role of HER2 in cancer. Oncogene 22: 6570-6578.
    • (2003) Oncogene , vol.22 , pp. 6570-6578
    • Ménard, S.1    Pupa, S.M.2    Campiglio, M.3
  • 13
    • 76049105429 scopus 로고    scopus 로고
    • Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives
    • Menendez JA,. 2010. Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives. Biochim Biophys Acta 1801: 381-391.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 381-391
    • Menendez, J.A.1
  • 14
    • 23044480300 scopus 로고    scopus 로고
    • Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
    • Menendez JA, Vellon L, Lupu R,. 2005a. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Ann Oncol 16: 1253-1267.
    • (2005) Ann Oncol , vol.16 , pp. 1253-1267
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 15
    • 14344250142 scopus 로고    scopus 로고
    • Orlistat: From antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors?
    • Menendez JA, Vellon L, Lupu R,. 2005b. Orlistat: from antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors? Exp Biol Med 230: 151-154.
    • (2005) Exp Biol Med , vol.230 , pp. 151-154
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 16
    • 15244355117 scopus 로고    scopus 로고
    • Targeting fatty acid synthase-driven lipid rafts: A novel strategy to overcome trastuzumab resistance in breast cancer cells
    • Menendez JA, Vellon L, Lupu R,. 2005c. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses 64: 997-1001.
    • (2005) Med Hypotheses , vol.64 , pp. 997-1001
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 17
    • 3242685815 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
    • Menendez JA, Vellon L, Mehmi I, et al,. 2004. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA 101: 10715-10720.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10715-10720
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3
  • 18
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, et al,. 2006. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 3: 269-280.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3
  • 19
    • 0029949512 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
    • Pizer ES, Jackisch C, Wood FD, et al,. 1996. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res 56: 2745-2747.
    • (1996) Cancer Res , vol.56 , pp. 2745-2747
    • Pizer, E.S.1    Jackisch, C.2    Wood, F.D.3
  • 20
    • 43749100987 scopus 로고    scopus 로고
    • Fatty acid metabolism in breast cancer cells: Differential inhibitory effects of epigallocatechin gallate (EGCG) and C75
    • Puig T, Vázquez-Martín A, Relat J, et al,. 2008. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast Cancer Res Treat 109: 471-479.
    • (2008) Breast Cancer Res Treat , vol.109 , pp. 471-479
    • Puig, T.1    Vázquez-Martín, A.2    Relat, J.3
  • 21
    • 0043172415 scopus 로고    scopus 로고
    • The SREBP pathway - Insights from Insigs and insects
    • Rawson RB,. 2003. The SREBP pathway - insights from Insigs and insects. Nat Rev Mol Cell Biol 4: 631-640.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 631-640
    • Rawson, R.B.1
  • 22
    • 0031617025 scopus 로고    scopus 로고
    • Regulation of fat synthesis and adipose differentiation
    • Sul HS, Smas CM, Wang D, et al,. 1998. Regulation of fat synthesis and adipose differentiation. Prog Nucleic Acid Res Mol Biol 60: 317-345.
    • (1998) Prog Nucleic Acid Res Mol Biol , vol.60 , pp. 317-345
    • Sul, H.S.1    Smas, C.M.2    Wang, D.3
  • 23
    • 0036497907 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    • Swinnen JV, Roskams T, Joniau S, et al,. 2002. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 98: 19-22.
    • (2002) Int J Cancer , vol.98 , pp. 19-22
    • Swinnen, J.V.1    Roskams, T.2    Joniau, S.3
  • 24
    • 73949094795 scopus 로고    scopus 로고
    • Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients
    • Vazquez-Martin A, Fernandez-Real JM, Oliveras-Ferraros C, et al,. 2009. Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients. Int J Oncol 35: 1369-1376.
    • (2009) Int J Oncol , vol.35 , pp. 1369-1376
    • Vazquez-Martin, A.1    Fernandez-Real, J.M.2    Oliveras-Ferraros, C.3
  • 25
    • 43849113129 scopus 로고    scopus 로고
    • A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol
    • Wang Y, Ye L, Leung LK,. 2008. A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol. Toxicology 248: 130-135.
    • (2008) Toxicology , vol.248 , pp. 130-135
    • Wang, Y.1    Ye, L.2    Leung, L.K.3
  • 26
    • 33846632826 scopus 로고    scopus 로고
    • Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling
    • Weng MS, Ho CT, Ho YS, et al,. 2007. Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling. Toxicol Appl Pharmacol 218: 107-118.
    • (2007) Toxicol Appl Pharmacol , vol.218 , pp. 107-118
    • Weng, M.S.1    Ho, C.T.2    Ho, Y.S.3
  • 27
    • 17444448391 scopus 로고    scopus 로고
    • The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis
    • Xing X, Wang SC, Xia W, et al,. 2000. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med 6: 189-195.
    • (2000) Nat Med , vol.6 , pp. 189-195
    • Xing, X.1    Wang, S.C.2    Xia, W.3
  • 28
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, et al,. 2002. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 279: 80-90.
    • (2002) Exp Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3
  • 29
    • 0037440477 scopus 로고    scopus 로고
    • Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
    • Yang YA, Morin PJ, Han WF, et al,. 2003. Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res 282: 132-137.
    • (2003) Exp Cell Res , vol.282 , pp. 132-137
    • Yang, Y.A.1    Morin, P.J.2    Han, W.F.3
  • 30
    • 0242490895 scopus 로고    scopus 로고
    • Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: A possible mechanism for their hypolipidemic effects
    • Yeh CW, Chen WJ, Chiang CT, et al,. 2003. Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Pharmacogenomics J 3: 267-276.
    • (2003) Pharmacogenomics J , vol.3 , pp. 267-276
    • Yeh, C.W.1    Chen, W.J.2    Chiang, C.T.3
  • 31
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • Yoon S, Lee MY, Park SW, et al,. 2007. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem 282: 26122-26131.
    • (2007) J Biol Chem , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3
  • 32
    • 28644439593 scopus 로고    scopus 로고
    • Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer
    • Zhang D, Tai LK, Wong LL, et al,. 2005. Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics 4: 1686-1696.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1686-1696
    • Zhang, D.1    Tai, L.K.2    Wong, L.L.3
  • 33
    • 33749329775 scopus 로고    scopus 로고
    • Fatty acid synthase: A novel target for antiglioma therapy
    • Zhao W, Kridel S, Thorburn A, et al,. 2006. Fatty acid synthase: a novel target for antiglioma therapy. Br J Cancer 95: 869-878.
    • (2006) Br J Cancer , vol.95 , pp. 869-878
    • Zhao, W.1    Kridel, S.2    Thorburn, A.3
  • 34
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou X, Tan M, Stone Hawthorne V, et al,. 2004. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res 10: 6779-6788.
    • (2004) Clin Cancer Res , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone Hawthorne, V.3


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