Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 6224-6234

  Vargiu, Attilio V ^a   Ruggerone, Paolo ^a   Opperman, Timothy J ^b   Nguyen, Son T ^b   Nikaido, Hiroshi ^c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b MICROBIOTIX INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 NAPHTHYLMETHYL)PIPERAZINE; ANTIBIOTIC AGENT; D 13 9001; DOXORUBICIN; MBX 2319; MINOCYCLINE; PHENYLALANINE; PHENYLALANYLARGININE BETA NAPHTHYLAMIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; ENTEROBACTERIACEAE; ESCHERICHIA COLI; ESCHERICHIA COLI ACRB; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; X RAY CRYSTALLOGRAPHY;

EID: 84907267776     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03283-14     Document Type: Article

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