Functional rotation of the transporter AcrB: Insights into drug extrusion from simulations

PLoS Computational Biology

Volumn 6, Issue 6, 2010, Pages 1-10

  Schulz, Robert ^a   Vargiu, Attilio V ^b   Collu, Francesca ^b   Kleinekathöfer, Ulrich ^a   Ruggerone, Paolo ^b  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CONFORMATIONS; CRYSTAL ATOMIC STRUCTURE; ESCHERICHIA COLI; EXTRUSION; MOLECULAR DYNAMICS; ROTATION;

ACTIVE PARTS; BINDING POCKETS; BIOCHEMICAL DATA; CONFORMATIONAL CHANGE; CRYSTAL STRUCTURE DATA; ENERGY TRANSDUCTION; MOLECULAR LEVELS; NOXIOUS COMPOUNDS; SELECTIVE BINDING; WIDE SPECTRUM;

SUBSTRATES;

CARRIER PROTEIN; DOXORUBICIN; PROTEIN ACRB; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG TRANSPORT; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIMULATION;

EID: 77955477744     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000806     Document Type: Article

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