A periplasmic drug-binding site of the AcrB multidrug efflux pump: A crystallographic and site-directed mutagenesis study

Journal of Bacteriology

Volumn 187, Issue 19, 2005, Pages 6804-6815

  Yu, Edward W ^a,b   Aires, Julio R ^a,d   McDermott, Gerry ^c   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; ETHIDIUM; LIGAND; MEMBRANE PROTEIN; NAFCILLIN; PHENYLALANYLARGININE BETA NAPHTHYLAMIDE; PROTEIN ACRB; RHODAMINE 6G; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CELL; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; DRUG PROTEIN BINDING; DRUG TRANSPORT; ESCHERICHIA COLI; GENETIC ANALYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ALANINE; ANTI-INFECTIVE AGENTS; ASPARAGINE; BINDING SITES; CARRIER PROTEINS; CIPROFLOXACIN; CRYSTALLOGRAPHY; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; PERIPLASMIC PROTEINS; PLASMIDS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 25144504245     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.187.19.6804-6815.2005     Document Type: Article

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