Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5687-5692

  Eicher, Thomas ^a,b   Cha, Hi Jea ^a   Seeger, Markus A ^b   Brandstätter, Lorenz ^a,b   El Delik, Jasmin ^a   Bohnert, Jürgen A ^c   Kern, Winfried V ^c   Verrey, François ^b   Grütter, Markus G ^b   Diederichs, Kay ^d   Pos, Klaas M ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Antibiotics; Drug efflux; Multidrug resistance; RND transporter

Indexed keywords

ANKYRIN; CARRIER PROTEIN; DOXORUBICIN; MINOCYCLINE; MONOMER; PROTEIN ACRB; PROTEIN VARIANT; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TRANSPORT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; TRANSPORT KINETICS; WILD TYPE;

BINDING SITES; BIOCATALYSIS; BIOLOGICAL TRANSPORT; DOXORUBICIN; ESCHERICHIA COLI PROTEINS; MINOCYCLINE; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

ESCHERICHIA COLI;

EID: 84859567740     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114944109     Document Type: Article

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