Some ligands enhance the efflux of other ligands by the escherichia coli multidrug pump AcrB

Biochemistry

Volumn 52, Issue 46, 2013, Pages 8342-8351

  Kinana, Alfred D ^a   Vargiu, Attilio V ^b   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; CONFORMATIONAL CHANGE; EFFLUX PUMPS; INTACT CELLS; LIGAND BINDING; MOLECULAR DYNAMICS SIMULATIONS; NITROCEFIN; WILD TYPES;

ANTIBIOTICS; BENZENE; COMPUTER SIMULATION; ESCHERICHIA COLI; EXTRUSION; MOLECULAR DYNAMICS; OLIGOMERS; SEWAGE TREATMENT PLANTS; SOLVENTS;

LIGANDS;

AZITHROMYCIN; BENZENE; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CYCLOHEXANE; CYCLOHEXANONE; DEOXYCHOLIC ACID; ERYTHROMYCIN; MULTIDRUG RESISTANCE PROTEIN; N BENZOYLARGININE 2 NAPHTHYLAMIDE; NALIDIXIC ACID; NITROCEFIN; NOVOBIOCIN; TAUROCHOLIC ACID;

ARTICLE; BINDING SITE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; EFFUSION; ESCHERICHIA COLI; HYPOTHESIS; LIGAND BINDING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RESTRICTION SITE;

ARGININE; BENZENE; CEFAMANDOLE; CEPHALOSPORINS; CHLORAMPHENICOL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; KINETICS; LIGANDS; MINOCYCLINE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; THERMODYNAMICS;

EID: 84888246858     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401303v     Document Type: Article

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