Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 15, 2010, Pages 6559-6565

  Takatsuka, Yumiko ^a,b   Chen, Cheng ^a   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YAMAGATA UNIVERSITY   (Japan)

Author keywords

Computer modeling; Drug efflux; Multidrug resistance; RND transporter

Indexed keywords

ACRB PROTEIN; ADAPTOR PROTEIN; CEFAMANDOLE; CHLORAMPHENICOL; CHOLIC ACID DERIVATIVE; DOXORUBICIN; ERYTHROMYCIN; ETHIDIUM; FLUORESCEIN; LEVOFLOXACIN; LINEZOLID; MALEIMIDE DERIVATIVE; MINOCYCLINE; NAFCILLIN; NITROCEFIN; NOVOBIOCIN; TETRACYCLINE; TRITON X 100; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; MOLECULAR DOCKING; MOLECULAR RECOGNITION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

BINDING, COMPETITIVE; CEPHALOSPORINS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUORESCEINS; LIGANDS; MINOCYCLINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PROTEIN BINDING;

ESCHERICHIA COLI;

EID: 77951074736     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001460107     Document Type: Article

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