Amino acid sensing in dietary-restriction-mediated longevity: Roles of signal-transducing kinases GCN2 and TOR

Biochemical Journal

Volumn 449, Issue 1, 2013, Pages 1-10

  Gallinetti, Jordan ^a   Harputlugil, Eylul ^a   Mitchell, James R ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Amino acid; Dietary restriction (DR); Eukaryotic initiation factor 2 (eIF2 ); General amino acid control non derepressible 2 (GCN2); Target of rapamycin (TOR)

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; GENERAL AMINO ACID CONTROL NON DEREPRESSIBLE 2; GUANOSINE TRIPHOSPHATASE; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MEMBRANE PROTEIN; MESSENGER RNA; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ADIPOCYTE; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; AMINO ACID DEFICIENCY; AUTOPHAGY; AUTOPHOSPHORYLATION; BINDING KINETICS; DIET RESTRICTION; DOWN REGULATION; ENZYME ACTIVITY; HELA CELL; HUMAN; INHIBITION KINETICS; MICROAUTOPHAGY; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; PSORIASIS; REVIEW; SIGNAL TRANSDUCTION; START CODON; STRESS; TRANSCRIPTION REGULATION; UPREGULATION;

AMINO ACIDS; ANIMALS; CALORIC RESTRICTION; HUMANS; LONGEVITY; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EUKARYOTA; MAMMALIA;

EID: 84870885054     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121098     Document Type: Review

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