The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling

Journal of Biological Chemistry

Volumn 289, Issue 35, 2014, Pages 24691-24699

  Shanmugasundaram, Karthigayan ^a   Nayak, Bijaya ^a   Shim, Eun Hee ^c   Livi, Carolina B ^b   Block, Karen ^a,d   Sudarshan, Sunil ^c  

^a University of Texas Health Science Center   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c Hugh Kaul Human Genetics Building   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; GENE ENCODING;

BINDING KINASE; CELLULAR MODEL; ELEVATED LEVEL; INTERMEDIARY METABOLISM; PROTEIN ACCUMULATION; RENAL CELL CANCERS; THERAPEUTIC TARGETS; TRICARBOXYLIC ACID CYCLE;

TUMORS;

FUMARATE HYDRATASE; FUMARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOTRANSFERASE; SYNAPTOTAGMIN I; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; FUMARIC ACID DERIVATIVE; HIF1A PROTEIN, HUMAN; PRIMER DNA;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CARCINOMA CELL; CELL HYPOXIA; CELL INVASION; CONTROLLED STUDY; EMBRYO; ENZYME DEFICIENCY; ENZYME INHIBITION; FH GENE; GENE LOSS; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CELL HYPOXIA; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; FUMARATES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NF-KAPPA B; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84906861736     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.568162     Document Type: Article

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