Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 11, 2006, Pages 4240-4245

  Korherr, Christian ^a   Gille, Hendrik ^a,d   Schäfer, Rolf ^a   Koenig Hoffmann, Kerstin ^a   Dixelius, Johan ^b   Egland, Kristi A ^c,e   Pastan, Ira ^c   Brinkmann, Ulrich ^a,f  

^a Xantos Biomedicine AG   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Pieris Pharmaceuticals GmbH   (Germany)

^e UNIVERSITY OF SOUTH DAKOTA   (United States)

^f NONE   (Germany)

Author keywords

Cancer; cDNA libraries; Expression cloning; Human umbilical vein endothelial cells; Screening

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; INTERFERON REGULATORY FACTOR 3; PHOSPHOTRANSFERASE; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER; CANCER THERAPY; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA LIBRARY; DRUG TARGETING; EMBRYO; ENDOTHELIUM CELL; FUNCTIONAL GENOMICS; GENE; GENE EXPRESSION; GENE IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOXIA; IRF3 GENE; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SOLID TUMOR; TBK1 GENE; TUMOR GROWTH; TUMOR VASCULARIZATION; UMBILICAL VEIN;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; BASE SEQUENCE; CELL HYPOXIA; CELL PROLIFERATION; CELLS, CULTURED; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENOMICS; HUMANS; INTERFERON REGULATORY FACTOR-3; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 33645217264     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0511319103     Document Type: Article

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