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Volumn 161, Issue 2, 2014, Pages 184-188

Persistent inflammation in HIV infection: Established concepts, new perspectives

Author keywords

AIDS, CD4; HIV; Immune activation; Inflammation

Indexed keywords

CYTOKINE; NUCLEIC ACID; TOLL LIKE RECEPTOR; AUTACOID;

EID: 84906794202     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.01.008     Document Type: Article
Times cited : (57)

References (61)
  • 1
    • 0033827042 scopus 로고    scopus 로고
    • Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue
    • Anton P.A., Elliott J., Poles M.A., McGowan I.M., Matud J., Hultin L.E., et al. Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS 2000, 14:1761-1765.
    • (2000) AIDS , vol.14 , pp. 1761-1765
    • Anton, P.A.1    Elliott, J.2    Poles, M.A.3    McGowan, I.M.4    Matud, J.5    Hultin, L.E.6
  • 2
    • 0034967731 scopus 로고    scopus 로고
    • HIV-related diarrhea is multifactorial and fat malabsorption is commonly present, independent of HAART
    • Poles M.A., Fuerst M., McGowan I., Elliott J., Rezaei A., Mark D., et al. HIV-related diarrhea is multifactorial and fat malabsorption is commonly present, independent of HAART. Am J Gastroenterol 2001, 96:1831-1837.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1831-1837
    • Poles, M.A.1    Fuerst, M.2    McGowan, I.3    Elliott, J.4    Rezaei, A.5    Mark, D.6
  • 3
    • 20444365531 scopus 로고    scopus 로고
    • Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis
    • Li Z., Xiong Y., Peng Y., Pan J., Chen Y., Wu X., et al. Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Lett 2005, 579:3100-3106.
    • (2005) FEBS Lett , vol.579 , pp. 3100-3106
    • Li, Z.1    Xiong, Y.2    Peng, Y.3    Pan, J.4    Chen, Y.5    Wu, X.6
  • 4
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005, 434:1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 5
    • 0142092389 scopus 로고    scopus 로고
    • Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    • Guadalupe M., Reay E., Sankaran S., Prindiville T., Flamm J., McNeil A., et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol 2003, 77:11708-11717.
    • (2003) J Virol , vol.77 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3    Prindiville, T.4    Flamm, J.5    McNeil, A.6
  • 6
    • 33845904393 scopus 로고    scopus 로고
    • Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
    • Mehandru S., Poles M.A., Tenner-Racz K., Jean-Pierre P., Manuelli V., Lopez P., et al. Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS Med 2006, 3:e484.
    • (2006) PLoS Med , vol.3
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3    Jean-Pierre, P.4    Manuelli, V.5    Lopez, P.6
  • 7
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru S., Poles M.A., Tenner-Racz K., Horowitz A., Hurley A., Hogan C., et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004, 200:761-770.
    • (2004) J Exp Med , vol.200 , pp. 761-770
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3    Horowitz, A.4    Hurley, A.5    Hogan, C.6
  • 8
    • 84855417479 scopus 로고    scopus 로고
    • Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
    • Mavigner M., Cazabat M., Dubois M., L'Faqihi F.E., Requena M., Pasquier C., et al. Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals. J Clin Invest 2012, 122:62-69.
    • (2012) J Clin Invest , vol.122 , pp. 62-69
    • Mavigner, M.1    Cazabat, M.2    Dubois, M.3    L'Faqihi, F.E.4    Requena, M.5    Pasquier, C.6
  • 9
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007, 8:1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6
  • 11
    • 49649129676 scopus 로고    scopus 로고
    • Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients
    • Ancuta P., Kamat A., Kunstman K.J., Kim E.Y., Autissier P., Wurcel A., et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One 2008, 3:e2516.
    • (2008) PLoS One , vol.3
    • Ancuta, P.1    Kamat, A.2    Kunstman, K.J.3    Kim, E.Y.4    Autissier, P.5    Wurcel, A.6
  • 12
    • 84883417251 scopus 로고    scopus 로고
    • Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation
    • Kim C.J., McKinnon L.R., Kovacs C., Kandel G., Huibner S., Chege D., et al. Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation. J Immunol 2013, 191:2164-2173.
    • (2013) J Immunol , vol.191 , pp. 2164-2173
    • Kim, C.J.1    McKinnon, L.R.2    Kovacs, C.3    Kandel, G.4    Huibner, S.5    Chege, D.6
  • 13
    • 63149107945 scopus 로고    scopus 로고
    • Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection
    • Shen R., Richter H.E., Clements R.H., Novak L., Huff K., Bimczok D., et al. Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol 2009, 83:3258-3267.
    • (2009) J Virol , vol.83 , pp. 3258-3267
    • Shen, R.1    Richter, H.E.2    Clements, R.H.3    Novak, L.4    Huff, K.5    Bimczok, D.6
  • 14
    • 79952072460 scopus 로고    scopus 로고
    • Macrophages and cell-cell spread of HIV-1
    • Waki K., Freed E.O. Macrophages and cell-cell spread of HIV-1. Viruses 2010, 2:1603-1620.
    • (2010) Viruses , vol.2 , pp. 1603-1620
    • Waki, K.1    Freed, E.O.2
  • 16
    • 77950659445 scopus 로고    scopus 로고
    • The macrophage in HIV-1 infection: from activation to deactivation?
    • Herbein G., Varin A. The macrophage in HIV-1 infection: from activation to deactivation?. Retrovirology 2010, 7:33.
    • (2010) Retrovirology , vol.7 , pp. 33
    • Herbein, G.1    Varin, A.2
  • 17
    • 42049095290 scopus 로고    scopus 로고
    • The mucosal barrier and immune activation in HIV pathogenesis
    • Brenchley J.M., Douek D.C. The mucosal barrier and immune activation in HIV pathogenesis. Curr Opin HIV AIDS 2008, 3:356-361.
    • (2008) Curr Opin HIV AIDS , vol.3 , pp. 356-361
    • Brenchley, J.M.1    Douek, D.C.2
  • 18
    • 77954059792 scopus 로고    scopus 로고
    • Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    • Nazli A., Chan O., Dobson-Belaire W.N., Ouellet M., Tremblay M.J., Gray-Owen S.D., et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog 2010, 6:e1000852.
    • (2010) PLoS Pathog , vol.6
    • Nazli, A.1    Chan, O.2    Dobson-Belaire, W.N.3    Ouellet, M.4    Tremblay, M.J.5    Gray-Owen, S.D.6
  • 19
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper L.V., Littman D.R., Macpherson A.J. Interactions between the microbiota and the immune system. Science 2012, 336:1268-1273.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 20
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6
  • 21
    • 77952916199 scopus 로고    scopus 로고
    • Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy
    • Wallet M.A., Rodriguez C.A., Yin L., Saporta S., Chinratanapisit S., Hou W., et al. Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. AIDS 2010, 24:1281-1290.
    • (2010) AIDS , vol.24 , pp. 1281-1290
    • Wallet, M.A.1    Rodriguez, C.A.2    Yin, L.3    Saporta, S.4    Chinratanapisit, S.5    Hou, W.6
  • 22
    • 77958083540 scopus 로고    scopus 로고
    • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    • Estes J.D., Harris L.D., Klatt N.R., Tabb B., Pittaluga S., Paiardini M., et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog 2010, 6:e1001052.
    • (2010) PLoS Pathog , vol.6
    • Estes, J.D.1    Harris, L.D.2    Klatt, N.R.3    Tabb, B.4    Pittaluga, S.5    Paiardini, M.6
  • 23
    • 85027956964 scopus 로고    scopus 로고
    • Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count
    • Marchetti G., Cozzi-Lepri A., Merlini E., Bellistri G.M., Castagna A., Galli M., et al. Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count. AIDS 2011, 25:1385-1394.
    • (2011) AIDS , vol.25 , pp. 1385-1394
    • Marchetti, G.1    Cozzi-Lepri, A.2    Merlini, E.3    Bellistri, G.M.4    Castagna, A.5    Galli, M.6
  • 24
    • 77950267769 scopus 로고    scopus 로고
    • Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections
    • Nowroozalizadeh S., Mansson F., da Silva Z., Repits J., Dabo B., Pereira C., et al. Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections. J Infect Dis 2010, 201:1150-1154.
    • (2010) J Infect Dis , vol.201 , pp. 1150-1154
    • Nowroozalizadeh, S.1    Mansson, F.2    da Silva, Z.3    Repits, J.4    Dabo, B.5    Pereira, C.6
  • 25
    • 84865317040 scopus 로고    scopus 로고
    • The role of lipopolysaccharide as a marker of immune activation in HIV-1 infected patients: a systematic literature review
    • Vassallo M., Mercie P., Cottalorda J., Ticchioni M., Dellamonica P. The role of lipopolysaccharide as a marker of immune activation in HIV-1 infected patients: a systematic literature review. Virol J 2012, 9:174.
    • (2012) Virol J , vol.9 , pp. 174
    • Vassallo, M.1    Mercie, P.2    Cottalorda, J.3    Ticchioni, M.4    Dellamonica, P.5
  • 26
    • 84871703067 scopus 로고    scopus 로고
    • Microbial translocation, immune activation, and HIV disease
    • Klatt N.R., Funderburg N.T., Brenchley J.M. Microbial translocation, immune activation, and HIV disease. Trends Microbiol 2013, 21:6-13.
    • (2013) Trends Microbiol , vol.21 , pp. 6-13
    • Klatt, N.R.1    Funderburg, N.T.2    Brenchley, J.M.3
  • 27
    • 84879398925 scopus 로고    scopus 로고
    • Mucosal immunity in human and simian immunodeficiency lentivirus infections
    • Brenchley J.M. Mucosal immunity in human and simian immunodeficiency lentivirus infections. Mucosal Immunol 2013, 6:657-665.
    • (2013) Mucosal Immunol , vol.6 , pp. 657-665
    • Brenchley, J.M.1
  • 28
    • 71549143183 scopus 로고    scopus 로고
    • Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies/ml HIV-1 RNA
    • Baroncelli S., Galluzzo C.M., Pirillo M.F., Mancini M.G., Weimer L.E., Andreotti M., et al. Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies/ml HIV-1 RNA. J Clin Virol 2009, 46:367-370.
    • (2009) J Clin Virol , vol.46 , pp. 367-370
    • Baroncelli, S.1    Galluzzo, C.M.2    Pirillo, M.F.3    Mancini, M.G.4    Weimer, L.E.5    Andreotti, M.6
  • 30
    • 0029006189 scopus 로고
    • Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome
    • Cossarizza A., Ortolani C., Mussini C., Borghi V., Guaraldi G., Mongiardo N., et al. Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome. J Infect Dis 1995, 172:105-112.
    • (1995) J Infect Dis , vol.172 , pp. 105-112
    • Cossarizza, A.1    Ortolani, C.2    Mussini, C.3    Borghi, V.4    Guaraldi, G.5    Mongiardo, N.6
  • 32
    • 33745363316 scopus 로고    scopus 로고
    • Immunopathogenesis of acute AIDS virus infection
    • Picker L.J. Immunopathogenesis of acute AIDS virus infection. Curr Opin Immunol 2006, 18:399-405.
    • (2006) Curr Opin Immunol , vol.18 , pp. 399-405
    • Picker, L.J.1
  • 33
    • 0031018842 scopus 로고    scopus 로고
    • Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome
    • Cossarizza A., Mussini C., Mongiardo N., Borghi V., Sabbatini A., De Rienzo B., et al. Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome. AIDS 1997, 11:19-26.
    • (1997) AIDS , vol.11 , pp. 19-26
    • Cossarizza, A.1    Mussini, C.2    Mongiardo, N.3    Borghi, V.4    Sabbatini, A.5    De Rienzo, B.6
  • 34
    • 0000892945 scopus 로고    scopus 로고
    • Phenotypic characteristics and tendency to apoptosis of peripheral blood mononuclear cells from HIV+ long term non progressors
    • Franceschi C., Franceschini M.G., Boschini A., Trenti T., Nuzzo C., Castellani G., et al. Phenotypic characteristics and tendency to apoptosis of peripheral blood mononuclear cells from HIV+ long term non progressors. Cell Death Differ 1997, 4:815-823.
    • (1997) Cell Death Differ , vol.4 , pp. 815-823
    • Franceschi, C.1    Franceschini, M.G.2    Boschini, A.3    Trenti, T.4    Nuzzo, C.5    Castellani, G.6
  • 35
    • 77957584418 scopus 로고    scopus 로고
    • T cell immunity in acute HIV-1 infection
    • Streeck H., Nixon D.F. T cell immunity in acute HIV-1 infection. J Infect Dis 2010, 202(Suppl 2):S302-S308.
    • (2010) J Infect Dis , vol.202 , Issue.SUPPL 2
    • Streeck, H.1    Nixon, D.F.2
  • 36
    • 58149378337 scopus 로고    scopus 로고
    • HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    • Catalfamo M., Di Mascio M., Hu Z., Srinivasula S., Thaker V., Adelsberger J., et al. HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells. PNAS 2008, 105:19851-19856.
    • (2008) PNAS , vol.105 , pp. 19851-19856
    • Catalfamo, M.1    Di Mascio, M.2    Hu, Z.3    Srinivasula, S.4    Thaker, V.5    Adelsberger, J.6
  • 37
    • 8544221894 scopus 로고    scopus 로고
    • Balanced regulation of mRNA production for Fas and Fas ligand in lymphocytes from centenarians: how the immune system starts its second century
    • Pinti M., Troiano L., Nasi M., Bellodi C., Ferraresi R., Mussi C., et al. Balanced regulation of mRNA production for Fas and Fas ligand in lymphocytes from centenarians: how the immune system starts its second century. Circulation 2004, 110:3108-3114.
    • (2004) Circulation , vol.110 , pp. 3108-3114
    • Pinti, M.1    Troiano, L.2    Nasi, M.3    Bellodi, C.4    Ferraresi, R.5    Mussi, C.6
  • 38
    • 79957888573 scopus 로고    scopus 로고
    • Mechanisms of HIV-associated lymphocyte apoptosis: 2010
    • Cummins N.W., Badley A.D. Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis 2010, 1:e99.
    • (2010) Cell Death Dis , vol.1
    • Cummins, N.W.1    Badley, A.D.2
  • 39
    • 68249136806 scopus 로고    scopus 로고
    • The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors
    • Jiao Y., Fu J., Xing S., Fu B., Zhang Z., Shi M., et al. The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology 2009, 128:e366-e375.
    • (2009) Immunology , vol.128
    • Jiao, Y.1    Fu, J.2    Xing, S.3    Fu, B.4    Zhang, Z.5    Shi, M.6
  • 40
    • 44849137950 scopus 로고    scopus 로고
    • Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    • Funderburg N., Luciano A.A., Jiang W., Rodriguez B., Sieg S.F., Lederman M.M. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One 2008, 3:e1915.
    • (2008) PLoS One , vol.3
    • Funderburg, N.1    Luciano, A.A.2    Jiang, W.3    Rodriguez, B.4    Sieg, S.F.5    Lederman, M.M.6
  • 41
    • 79952705605 scopus 로고    scopus 로고
    • Revisiting immune exhaustion during HIV infection
    • Khaitan A., Unutmaz D. Revisiting immune exhaustion during HIV infection. Curr HIV/AIDS Rep 2011, 8:4-11.
    • (2011) Curr HIV/AIDS Rep , vol.8 , pp. 4-11
    • Khaitan, A.1    Unutmaz, D.2
  • 42
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry E.J., Blattman J.N., Murali-Krishna K., van der Most R., Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003, 77:4911-4927.
    • (2003) J Virol , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der Most, R.4    Ahmed, R.5
  • 43
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L., Janbazian L., Chomont N., Said E.A., Gimmig S., Bessette B., et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006, 12:1198-1202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3    Said, E.A.4    Gimmig, S.5    Bessette, B.6
  • 44
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day C.L., Kaufmann D.E., Kiepiela P., Brown J.A., Moodley E.S., Reddy S., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3    Brown, J.A.4    Moodley, E.S.5    Reddy, S.6
  • 45
    • 34249711903 scopus 로고    scopus 로고
    • PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors
    • Zhang J.Y., Zhang Z., Wang X., Fu J.L., Yao J., Jiao Y., et al. PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood 2007, 109:4671-4678.
    • (2007) Blood , vol.109 , pp. 4671-4678
    • Zhang, J.Y.1    Zhang, Z.2    Wang, X.3    Fu, J.L.4    Yao, J.5    Jiao, Y.6
  • 46
    • 58149277359 scopus 로고    scopus 로고
    • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    • Jones R.B., Ndhlovu L.C., Barbour J.D., Sheth P.M., Jha A.R., Long B.R., et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 2008, 205:2763-2779.
    • (2008) J Exp Med , vol.205 , pp. 2763-2779
    • Jones, R.B.1    Ndhlovu, L.C.2    Barbour, J.D.3    Sheth, P.M.4    Jha, A.R.5    Long, B.R.6
  • 47
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said E.A., Dupuy F.P., Trautmann L., Zhang Y., Shi Y., El-Far M., et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010, 16:452-459.
    • (2010) Nat Med , vol.16 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3    Zhang, Y.4    Shi, Y.5    El-Far, M.6
  • 48
    • 50649117100 scopus 로고    scopus 로고
    • The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche
    • Estes J.D., Haase A.T., Schacker T.W. The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. Semin Immunol 2008, 20:181-186.
    • (2008) Semin Immunol , vol.20 , pp. 181-186
    • Estes, J.D.1    Haase, A.T.2    Schacker, T.W.3
  • 49
    • 55249118882 scopus 로고    scopus 로고
    • The role of secondary lymphatic tissue in immune deficiency of HIV infection
    • Schacker T. The role of secondary lymphatic tissue in immune deficiency of HIV infection. AIDS 2008, 22(Suppl 3):S13-S18.
    • (2008) AIDS , vol.22 , Issue.SUPPL 3
    • Schacker, T.1
  • 50
    • 27944487152 scopus 로고    scopus 로고
    • Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
    • Schacker T.W., Reilly C., Beilman G.J., Taylor J., Skarda D., Krason D., et al. Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS 2005, 19:2169-2171.
    • (2005) AIDS , vol.19 , pp. 2169-2171
    • Schacker, T.W.1    Reilly, C.2    Beilman, G.J.3    Taylor, J.4    Skarda, D.5    Krason, D.6
  • 51
    • 77955421014 scopus 로고    scopus 로고
    • Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patients
    • Diaz A., Alos L., Leon A., Mozos A., Caballero M., Martinez A., et al. Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patients. AIDS 2010, 24:2029-2039.
    • (2010) AIDS , vol.24 , pp. 2029-2039
    • Diaz, A.1    Alos, L.2    Leon, A.3    Mozos, A.4    Caballero, M.5    Martinez, A.6
  • 53
    • 43049130865 scopus 로고    scopus 로고
    • HIV-1 reverse transcription initiation: a potential target for novel antivirals
    • Abbink T.E., Berkhout B. HIV-1 reverse transcription initiation: a potential target for novel antivirals. Virus Res 2008, 134:4-18.
    • (2008) Virus Res , vol.134 , pp. 4-18
    • Abbink, T.E.1    Berkhout, B.2
  • 54
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004, 303:1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 55
    • 78651401005 scopus 로고    scopus 로고
    • RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I
    • Solis M., Nakhaei P., Jalalirad M., Lacoste J., Douville R., Arguello M., et al. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J Virol 2011, 85:1224-1236.
    • (2011) J Virol , vol.85 , pp. 1224-1236
    • Solis, M.1    Nakhaei, P.2    Jalalirad, M.3    Lacoste, J.4    Douville, R.5    Arguello, M.6
  • 56
    • 84855301478 scopus 로고    scopus 로고
    • Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA
    • Berg R.K., Melchjorsen J., Rintahaka J., Diget E., Soby S., Horan K.A., et al. Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA. PLoS One 2012, 7:e29291.
    • (2012) PLoS One , vol.7
    • Berg, R.K.1    Melchjorsen, J.2    Rintahaka, J.3    Diget, E.4    Soby, S.5    Horan, K.A.6
  • 57
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D., Wu J., Wu Y.T., Du F., Aroh C., Yan N., et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 2013, 341:903-906.
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.T.3    Du, F.4    Aroh, C.5    Yan, N.6
  • 58
    • 84888002403 scopus 로고    scopus 로고
    • From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    • Jakobsen M.R., Bak R.O., Andersen A., Berg R.K., Jensen S.B., Jin T., et al. From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. PNAS 2013, 110:E4571-E4580.
    • (2013) PNAS , vol.110
    • Jakobsen, M.R.1    Bak, R.O.2    Andersen, A.3    Berg, R.K.4    Jensen, S.B.5    Jin, T.6
  • 59
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q., Raoof M., Chen Y., Sumi Y., Sursal T., Junger W., et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010, 464:104-107.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5    Junger, W.6
  • 60
    • 79961211355 scopus 로고    scopus 로고
    • Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation
    • Cossarizza A., Pinti M., Nasi M., Gibellini L., Manzini S., Roat E., et al. Increased plasma levels of extracellular mitochondrial DNA during HIV infection: a new role for mitochondrial damage-associated molecular patterns during inflammation. Mitochondrion 2011, 11:750-755.
    • (2011) Mitochondrion , vol.11 , pp. 750-755
    • Cossarizza, A.1    Pinti, M.2    Nasi, M.3    Gibellini, L.4    Manzini, S.5    Roat, E.6
  • 61
    • 84861564036 scopus 로고    scopus 로고
    • Mitochondrial DNA: a proinflammatory 'enemy from within' during HIV infection?
    • Pinti M., Mussini C., Cossarizza A. Mitochondrial DNA: a proinflammatory 'enemy from within' during HIV infection?. Cell Death Dis 2012, 3:307.
    • (2012) Cell Death Dis , vol.3 , pp. 307
    • Pinti, M.1    Mussini, C.2    Cossarizza, A.3


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